Leishmaniose tegumentar americana associada à AIDS: relato de quatro casos

Sampaio, Raimunda Nonata Ribeiro; Salaro, Cristina; Resende, Paula; Paula, Carmen Déa Ribeiro de

doi:10.1590/s0037-86822002000600017

Cited by 16 publications

(3 citation statements)

References 8 publications

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“…As for the clinical manifestations, they were similar to epidemiological studies, with the most frequent symptoms being fever, splenomegaly, pallor and hepatomegaly (Oliveira, Figueiredo, & Braga, 2014) In The types of lesions were verified, the most frequent lesion was the skin lesion, as it is the area of the body that is most exposed, it occurs through the bite of the sand fly, the mucosal lesion occurred in 14 patients and the classic form is secondary to skin lesion (Pinto, Paiva, Queiroz, Rapela, & Oliveira, 2010) The presence of comorbidity, regardless of sex, demonstrates that the clinical manifestations are similar to TL in immunocompetent patients, however, the immune system of HIV carriers is more susceptible to poor disease evolution (Sampaio, Salaro, Resende, & de Paula, 2002).…”

Section: Resultsmentioning

confidence: 99%

American Tegumentary Leishmaniasis in Montes Claros: an epidemiological study

Silva

Aguiar

et al. 2021

RSD

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Introduction: American Tegumentary Leishmaniasis (ATL), or kala azar, is a serious chronic disease caused by Leishmania spp. It is an infectious and non-contagious disease that affects both humans and several species of wild and domestic animals, presenting the clinical forms of cutaneous, mucocutaneous and diffuse cutaneous. ATL is classified as a generalized zoonotic disease that has a global impact. It is caused by protozoa of the genus Leishmania and is considered a serious public health problem. Objective: To describe the epidemiological profile of cases found in Montes Claros-MG. Methodology: An epidemiological assessment was performed based on secondary data from SINAN/MS from January 2010 to December 2015. Results: From 2010 to 2015, 286 cases of ATL were registered, with the majority of cases occurring in children under 19 years of age (31.81%) and patients over 59 years (17.83%) had a lower percentage of disease involvement. The first choice drug used by patients was Glucantime (87.06%). The most affected gender was male (52.44%) and most patients had no comorbidities (76.96%). Conclusion: In Montes Claros, Minas Gerais, ATL presented high cases during the research period. In this sense, this study guides the development of new researches that address and monitor the spread of the disease by monitoring urban areas concomitantly with the capture of animals for the presence of the parasite, thus assisting in public health decision-making in controlling the disease.

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Section: Resultsmentioning

confidence: 99%

American Tegumentary Leishmaniasis in Montes Claros: an epidemiological study

Silva

Aguiar

et al. 2021

RSD

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“…Quanto ao tratamento, as drogas de primeira escolha na LTA são os Atimoniais Pentavalentes (Sb+5) 20 , e não havendo resposta satisfatória ou havendo contra indicações ao tratamento, as drogas de segunda escolha são a Anfotericina B e a Pentamidina 1 . No caso apresentado, após a confirmação diagnóstica pela biópsia, o caso foi conduzido por equipe médica em ambiente hospitalar, que optou por não realizar nenhum tratamento local, e neste caso, a forma Lipossomal da Anfotericina B foi o medicamento de escolha para o tratamento, por agir especificamente sobre células-alvo (macrófagos), incorporando ao meio intracelular e assim reduzindo efeitos colaterais 21 . Porém, apesar da alta eficácia da Anfotericina 22 , este paciente apresentou episódio de recidiva, sendo necessário aumentar a dose do medicamento para sua total recuperação.…”

Section: Discussionunclassified

Abordagem multiprofissional no diagnóstico de leishmaniose: um relato de caso

Garbín¹,

Belila²,

Precinoti³

et al. 2017

Arch Health Invest

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Introdução: A Leishmaniose Tegumentar Americana (LTA) é uma doença crônica, grave, infecciosa e não contagiosa, sendo encontrada em quase toda a América Latina, afetando as populações autóctones e viajantes. Objetivo: Objetivou-se elucidar a importância da equipe multiprofissional para a realização do diagnóstico definitivo, de um caso de Leishmaniose Tegumentar Americana. Caso clínico: Paciente de 74 anos, sexo masculino, procurou o serviço de saúde com queixa de rouquidão e odinofagia. Ao exame médico, apresentou lesão irregular em palato duro e mole com proeminências lobuladas e ulceradas. Foram solicitados teste rápido e sorologia cujos resultados foram negativos. Para confirmação diagnóstica, foi requerido no serviço odontológico a biópsia da lesão e o teste Reação de Polimerase em Cadeia. Conclusão: Salientamos a importância da integração médico odontológica para conclusão do diagnóstico e realização do tratamento.Descritores: Leishmaniose; Leishmaniose Mucocutânea; Diagnóstico.

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“…Classical MCL caused by L. braziliensis infection is more severe in co-infection with more extensive lesions, such as diffuse infiltration of the palate; concomitant genital ulceration is common (27%) [35] , [91] , [114] , [116] . MCL has also been described in (not-imported) patients in Europe, and in some, the parasite was typed as L. infantum [117] – [120] .…”

Section: (Pkdl-like) Dermal Manifestations In Hiv-infected Patients Pmentioning

confidence: 99%

PKDL and Other Dermal Lesions in HIV Co-infected Patients with Leishmaniasis: Review of Clinical Presentation in Relation to Immune Responses

Zijlstra¹

2014

PLoS Negl Trop Dis

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BackgroundCo-infection of leishmaniasis and HIV is increasingly reported. The clinical presentation of leishmaniasis is determined by the host immune response to the parasite; as a consequence, this presentation will be influenced by HIV-induced immunosuppression. As leishmaniasis commonly affects the skin, increasing immunosuppression changes the clinical presentation, such as in post-kala-azar dermal leishmaniasis (PKDL) and cutaneous leishmaniasis (CL); dermal lesions are also commonly reported in visceral leishmaniasis (VL) and HIV co-infection.MethodsWe reviewed the literature with regard to dermal manifestations in leishmaniasis and HIV co-infection, in three clinical syndromes, according to the primary presentation: PKDL, VL, or CL.ResultsA wide variety of descriptions of dermal leishmaniasis in HIV co-infection has been reported. Lesions are commonly described as florid, symmetrical, non-ulcerating, nodular lesions with atypical distribution and numerous parasites. Pre-existing, unrelated dermal lesions may become parasitized. Parasites lose their tropism and no longer exclusively cause VL or CL. PKDL in HIV co-infected patients is more common and more severe and is not restricted to Leishmania donovani. In VL, dermal lesions occur in up to 18% of patients and may present as (severe) localized cutaneous leishmaniasis, disseminated cutaneous leishmaniasis (DL) or diffuse cutaneous leishmaniasis (DCL); there may be an overlap with para-kala-azar dermal leishmaniasis. In CL, dissemination in the skin may occur resembling DL or DCL; subsequent spread to the viscera may follow. Mucosal lesions are commonly found in VL or CL and HIV co-infection. Classical mucocutaneous leishmaniasis is more severe. Immune reconstitution disease (IRD) is uncommon in HIV co-infected patients with leishmaniasis on antiretroviral treatment (ART).ConclusionWith increasing immunosuppression, the clinical syndromes of CL, VL, and PKDL become more severe and may overlap. These syndromes may be best described as VL with disseminated cutaneous lesions (before, during, or after VL) and disseminated cutaneous leishmaniasis with or without visceralization.

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Leishmaniose tegumentar americana associada à AIDS: relato de quatro casos

Cited by 16 publications

References 8 publications

American Tegumentary Leishmaniasis in Montes Claros: an epidemiological study

American Tegumentary Leishmaniasis in Montes Claros: an epidemiological study

Abordagem multiprofissional no diagnóstico de leishmaniose: um relato de caso

PKDL and Other Dermal Lesions in HIV Co-infected Patients with Leishmaniasis: Review of Clinical Presentation in Relation to Immune Responses

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