The fifth industrial revolution and the accompanying influences of digitalization are presenting enterprises with significant challenges. Regardless of the trend, however, humans will remain a central resource in future factories and will continue to be required to perform manual tasks. Against the backdrop of, e.g., societal and demographic changes and skills shortage, future-oriented support technologies such as exoskeletons represent a promising opportunity to support workers. Accordingly, the increasing interconnection of human operators, devices, and the environment, especially in human-centered work processes, requires improved human-machine interaction and further qualification of support systems to smart devices. In order to meet these requirements and enable exoskeletons as a future-proof technology, this article presents a framework for the future-oriented qualification of exoskeletons, which reveals potential in terms of user-individual and context-dependent adaptivity of support systems. In this context, a framework has been developed, allowing different support situations to be classified based on elementary functions. Using these support function dependencies and characteristics, it becomes possible to describe adaptive system behavior for human-centered support systems such as exoskeletons as a central aspect. For practical illustration, it is shown for an exemplary active exoskeleton using the example of user-individuality and context-specificity how the support characteristics of exoskeletons in the form of different support characteristics can bring about a purposeful and needs-based application for users and can contribute valuably to design future workplaces.