Lemierre-Syndrom mit Milzabszessen

Kern, Winfried V.; Dolderer, M.; Krieger, David; Büchler, MarkusW.; P, Kern

doi:10.1055/s-2008-1062472

Cited by 13 publications

(5 citation statements)

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“…Abnormal liver function was detected in 49% of patients by Hagelskjaer et al (177), and patients may be frankly jaundiced (162,327,389,400). Liver abscesses, commonly multiple (37,92,125,218,227,279,286,365,400), were identified in 4% of patients in the current series of Lemierre's syndrome and splenic abscesses (9,106,219,222,236,327,392) in 3% patients. Liver abscesses have been reported in other necrobacillosis cases not fulfilling the criteria for Lemierre's syndrome (8,176,188,199,296,379).…”

Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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“…Hepatomegaly and splenomegaly are common, but splenic and hepatic abscess is rare. 15 Hospital stays of these patients are quite long, ranging from a few days to a few weeks.…”

Section: Discussionmentioning

confidence: 99%

Lemierre\'s Syndrome: A Retrospective Case Series

Kumar¹,

Gill²,

Resuciannie³

2023

International Journal of Head and Neck Surgery

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In most of the cases, oropharynx is the primary site of infection and exudative tonsillitis may be present in many cases, and sometimes just mild hyperemia and ulcers in the oropharynx and peritonsillar area are noted in some cases. The general signs are tenderness and hyperemia over the angle of jaw and pain with neck movement, which is sometimes associated with IntroductIonIn 1936, André Lemierre described a syndrome with post-anginal septicemia, which was complicated with thrombosis of the IJV and the presence of distant septic emboli in the patient's bloodstream. 1,2 It has gained a special status due to few cases coming to light and as a "forgotten" and a condition which is often missed in diagnosis resulting in various complications and poor patient outcomes and sometimes may result in mortality. [3][4][5] André Lemierre explained that septic emboli reaching IJV could originate from many sites such as nasopharynx, oral cavity, ear having otitis media, mastoiditis, uterus having purulent endometritis, and appendicitis. 4 The involvement of IJV provides a pathway for the spread of infection through bloodstream. The symptoms are tenderness in neck region, pain, fever with chills and rigors, and erythema in pharyngeal and peritonsillar region on oropharyngeal examination. Since the IJV is involved, the infection can potentially undergo hematogenous spread. The infection generally spreads to spleen, liver, kidney, heart, and brain. 6,7 Lemierre's syndrome can be diagnosed based on clinical symptoms, multitude of blood series, and imaging. Since it is an infectious condition, the treatment involves systemic antibiotic therapy, and early administration of broad-spectrum antibiotics in high dose becomes necessary for prevention of complications and systemic spread of infection. 8,9 EpIdEmIologyLemierre's syndrome is generally seen in young adults. 10 According to a study carried out in Denmark, there was an annual incidence

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“…Infection of the lung may be associated with pleural effusions [6,11,12], empyema [11,12] and/ or lung abscesses [13,14]. The joints are the second most common site of septic embolization [6,15], followed by other atypical manifestations including hepatic [16] and splenic abscesses [17], osteomyelitis [18,19], endocarditis [20], meningitis [21] and brain abscesses [22].…”

Section: Discussionmentioning

confidence: 99%

From a sore throat to the intensive care unit: the Lemierre syndrome

Hochmair

Valipour

Oschatz

et al. 2006

Wien Klin Wochenschr

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Lemierre syndrome is characterized by an acute oropharyngeal infection, suppurative thrombophlebitis of the internal jugular vein and metastatic infections. The infection is usually caused by Fusobacterium necrophorum. We report on a 19-year-old male patient who was admitted with a five-day history of fever, sore throat and progressive dyspnea. Computed tomography of the neck and chest revealed a parapharyngeal abscess, jugular vein thrombosis, descending necrotizing mediastinitis and multiple areas of bilateral consolidation and cavitations within the lungs. Fusobacterium necrophorum was identified in the blood culture. Early combined abscess drainage with neck and chest incisions, together with broad spectrum intravenous antibiotic treatment and medical management in an intensive care unit resulted in a good clinical outcome.

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Lemierre-Syndrom mit Milzabszessen

Cited by 13 publications

References 0 publications

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Lemierre\'s Syndrome: A Retrospective Case Series

From a sore throat to the intensive care unit: the Lemierre syndrome

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