Lemierre Syndrome and Acute Mastoiditis

Stokroos, Robert J.; Manni, Johannes J.; Kruijk, Jelle R. de; Soudijn, Eduard Rupert

doi:10.1001/archotol.125.5.589

Cited by 45 publications

(32 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13][14][15] Recently, there has been an increase in reports of sporadic cases of LS. 9,10,13,15,18,25,28 At our institution, we have seen a marked increase in the diagnosis of this unusual condition. The cause of this apparent increase is uncertain.…”

Section: Discussionmentioning

confidence: 89%

“…[7][8][9][10][11] However, thrombophlebitis can occur in a variety of vessels in the head and the neck, including the pharyngeal venous plexus and the peritonsillar veins. 25 LS also has been associated with cavernous sinus thrombosis and lateral sinus thrombosis. 25,26 Three of our patients with LS had definitive radiologic evidence of thrombophlebitis in the jugular system.…”

Section: Discussionmentioning

confidence: 99%

“…25 LS also has been associated with cavernous sinus thrombosis and lateral sinus thrombosis. 25,26 Three of our patients with LS had definitive radiologic evidence of thrombophlebitis in the jugular system. However, thrombophlebitis is not always documented despite suggestive clinical manifestations, as evident in patient 13, who developed pulmonary emboli but lacked a detectable thrombosed cervical vessel.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Increased Diagnosis of Lemierre Syndrome and Other Fusobacterium necrophorum Infections at a Children’s Hospital

et al. 2003

View full text Add to dashboard Cite

ABSTRACT. Objective. To assess the apparent increase in the diagnosis of Lemierre syndrome (LS) and other Fusobacterium necrophorum infections at a large children's hospital. Infections with F necrophorum ranged from peritonsillar abscess to potentially fatal LS. LS is an oropharyngeal infection characterized by septic thrombophlebitis of head and neck veins, complicated by dissemination of septic emboli to pulmonary and systemic sites.Methods. Review of the medical and laboratory records was conducted of all patients who were seen at or admitted to the Children's Hospital of Wisconsin with the diagnosis of LS and/or isolation of F necrophorum from a clinical specimen between January 1995 and January 2002.Results. During the 7-year period of the study, there was an increase in the isolation of Conclusions. The cause for the recent increase in the number of serious infections caused by F necrophorum infection diagnosed at our institution is unclear but does not seem to be related to changes in microbiologic techniques or patient demography. We speculate that it could be attributable, in part, to alterations in antibiotic usage patterns in our region. Clinicians need to be aware of the increasing clinical importance of F necrophorum infections and the life-threatening nature of LS. Pediatrics 2003;112:e380 -e385. URL: http://www.pediatrics.org/cgi/ content/full/112/5/e380; Fusobacterium necrophorum, Lemierre syndrome, peritonsillar abscess, thrombophlebitis, pulmonary emboli.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased Diagnosis of Lemierre Syndrome and Other Fusobacterium necrophorum Infections at a Children’s Hospital

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Bacterial sepsis (etiology unspecified) was identified as a risk factor in 4% of these. Sinovenous thrombosis is a recognized complication of F. necrophorum infection (20,211,370). In the current literature review, 15/251 patients with F. necrophorum infection had venous sinus thrombophlebitis; these patients ranged in age from 11 months to 38 years, with a median age of 15 years.…”

Section: Sinus Thrombosismentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

View full text Add to dashboard Cite

SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

show abstract

“…This is usually caused by the anaerobe Fusobacterium necrophorum and is heralded by spiking fevers, tenderness of the sternocleidomastoid muscle, neck stiffness and metastatic abscesses typically to the lung, but septic arthritis is also common. This may be a complication of acute mastoiditis and amygdalitis as well [11][12][13][14]. Among the infectious conditions, acute parotitis is also an etiologic factor.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Thrombosis of the Internal Jugular Vein: Unknown Origin

Doğru¹,

Yasan

Tüz

et al. 2001

Otorhinolaryngol Nova

View full text Add to dashboard Cite

Internal jugular vein thrombosis (IJVT) is a vascular disorder that results from various clinical conditions. The vast majority of IJVT are considered to be complications of central venous catheterization. The list of associated conditions must also be expanded and should include the following: mediastinal tumors, low antithrombin III levels, tumors associated with hypercoagulability, previous central venous catheterization, neck surgery, intravenous drug abuse, neoplasms of the head and neck, Hughes-Stovin syndrome, which is associated with pseudotumor cerebri and seizures in children, and other conditions such as local inflammation from radiation therapy or sepsis and infective cervical adenopathy. There are several cases in the literature related to spontaneous IJVT. Spontaneous IJVT may occur when there are no apparent predisposing mechanical or inflammatory causes although a few of these patients may harbor an occult neoplasm.

show abstract

Lemierre Syndrome and Acute Mastoiditis

Cited by 45 publications

References 9 publications

Increased Diagnosis of Lemierre Syndrome and Other Fusobacterium necrophorum Infections at a Children’s Hospital

Increased Diagnosis of Lemierre Syndrome and Other Fusobacterium necrophorum Infections at a Children’s Hospital

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Spontaneous Thrombosis of the Internal Jugular Vein: Unknown Origin

Contact Info

Product

Resources

About