Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women

Kim, Mi Joung; Hwang, Jung Hyun; Ko, Hyun Ji; Na, Hye Bock; Kim, Jung Hee

doi:10.1016/j.nutres.2015.04.001

Cited by 30 publications

(22 citation statements)

References 45 publications

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“…The study showed that C. limon juice caused a reduction in serum high-sensitive C-reactive protein (hs-CRP) in comparison with the placebo and normal diet group. Haemoglobin and haematocrit levels remained stable in the group on the lemon detox diet, while they decreased in the placebo and normal diet groups (Table 7) [62].…”

Section: Anti-obesity Activitymentioning

confidence: 93%

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Klimek-Szczykutowicz

Szopa

2020

Plants

288

153

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This review presents important botanical, chemical and pharmacological characteristics of Citrus limon (lemon)—a species with valuable pharmaceutical, cosmetic and culinary (healthy food) properties. A short description of the genus Citrus is followed by information on the chemical composition, metabolomic studies and biological activities of the main raw materials obtained from C. limon (fruit extract, juice, essential oil). The valuable biological activity of C. limon is determined by its high content of phenolic compounds, mainly flavonoids (e.g., diosmin, hesperidin, limocitrin) and phenolic acids (e.g., ferulic, synapic, p-hydroxybenzoic acids). The essential oil is rich in bioactive monoterpenoids such as D-limonene, β-pinene, γ-terpinene. Recently scientifically proven therapeutic activities of C. limon include anti-inflammatory, antimicrobial, anticancer and antiparasitic activities. The review pays particular attention, with references to published scientific research, to the use of C. limon in the food industry and cosmetology. It also addresses the safety of use and potential phototoxicity of the raw materials. Lastly, the review emphasizes the significance of biotechnological studies on C. limon.

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Section: Anti-obesity Activitymentioning

confidence: 93%

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Klimek-Szczykutowicz

Szopa

2020

Plants

288

153

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“…(2015) [16] therefore, a total of 45 participants were randomly assigned into one of the study groups.…”

Section: Sample Sizementioning

confidence: 99%

“…Several preliminary studies have demonstrated that food extracts and nutrients can regulate the transduction and eventual excretion of toxins [10][11][12][13][14][15]. Typically, detox diets are calorie-restricted diets consisting of a single fruits, vegetables, or beverages (tea, vinegar, lemon juice, salt water, or drinks mixed with micronutrients) [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The diet detox program known as the lemon diet and hypocaloric Mediterranean diet [16,26] were a very low-calorie diet (LCD) that allows 500 to 1,000 kcal per day and is effective in reducing body weight and fat; however, this dietary intervention is difficult to maintain and can lead to shortages of minerals, vitamins, and dietary fiber, as well as increased binge eating and stress [27,28].…”

Section: Introductionmentioning

confidence: 99%

“…Typically, detox diets are calorie-restricted diets consisting of a single fruits, vegetables, or beverages (tea, vinegar, lemon juice, salt water, or drinks mixed with micronutrients) [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The diet detox program known as the lemon diet and hypocaloric Mediterranean diet [16,26] were a very low-calorie diet (LCD) that allows 500 to 1,000 kcal per day and is effective in reducing body weight and fat; however, this dietary intervention is difficult to maintain and can lead to shortages of minerals, vitamins, and dietary fiber, as well as increased binge eating and stress [27,28]. Moreover, while fasting or LCDs may allow weight loss, they can also lead to various health problems, such as malnutrition, muscle weakness, nervousness, headaches, dizziness, fatigue, gastrointestinal disturbances, and reduced quality of life [29,30].…”

Section: Introductionmentioning

confidence: 99%

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Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial

Kim

Park

Lee

et al. 2020

Preprint

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Background: Detox diet are known as a popular dieting strategies that helps toxins elimination and weight manage but there is very little clinical evidence. The Wellnessup diet (WD) used in the present study designed as a healthy meals based on organic plant based diets including various vegetables, fruits, whole grains, nuts and phytonutrients.Methods: To evaluate the effects of 4 week intake of the WD on toxic trace element detoxification, body fat reduction, and safety parameters. Forty-five women with body mass index (BMI) of 23.5-30 kg/m2 were recruited. Thirty of them were assigned 1:1 to the test group (WD, 15 subjects) and control group 1 (calorie-restricted diet, CRD, 15 subjects) in a single blind and randomized, and the remaining 15 subjects were assigned to control group 2 (maintaining regular diet, MRD). The primary outcome were toxic trace element levels in hair (29 types of heavy metals), and the secondary outcomes were changes in anthropometric and urinary organic acids.Results: The levels of four toxic trace elements in hair decreased in the WD group after the diet compared to before the diet. Ni, Rh, Sn, and Ga were significantly lower in the WD group than in the CRD or MRD group (p<0.05). At the end of the trial, both WD and CRD groups had lower BMI, Waist Circumference(WC), Hip Circumference(HC) and WHR compared to the baseline values (p<0.05).Compared to the WD group, the CRD group had a greater mean change (p<0.05) from the baseline for weight loss (-3.22±0.48kg vs -1.88±0.95kg vs) and fat free mass (-2.08 kg vs -1.09 kg). The weight, BMI, body fat mass, fat free mass, WC, and HC of the CRD group were significantly decreased compared to the MRD (p<0.05). No significant changes in any safety parameter were observed.Conclusions: Use of WD might have several beneficial effects and safety such as body fat reduction and improving some the element detoxification through caloric restriction but did not reducing body fat mass more than calorie-restricted diet.

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“…'절식법'은 단식의 치료효과를 볼 수 있으면서 단식의 문제 점을 보완할 수 있어 최근에는 단식의 대체방법으로 선택되 고 있다 [6][7][8] . WBC: white blood cell, HPF: high power filed, RBC: red blood cell, SG: specific gravity, ＋: weak positive reaction, ＋＋: strong positive reaction, ＋＋＋: Extreme positive reaction.…”

Section: 한방비만학회지 제15권 제2호 2015unclassified

A Pilot Study to Develop Gamrosu, a Modified Fasting Therapy Beverage: Case Series

Kim²,

Shin

et al. 2015

JKOMOR

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Gamrosu is a modified fasting therapy beverage (431 kcal/d). A retrospective observational study was conducted to investigate the detoxification feasibility of Gamrosu. Three cases were reviewed which participants have finished the fasting with Garmrosu for 10 consecutive days. Detoxification profiles of Gamrosu were reviewed at pre-and post-fasting sessions. Post-Gamrosu session, −6.3% of average weight, −6.5% of average body fat mass and −6.6% of average muscle mass were reduced with the nutrition indices being improved. The inflammation indices showed the significant diminished profiles. Liver/kidney functions and the standard of electrolytes were maintained within normal range in stable manners, however, marginal elevation of total bilirubin and mild ketoacidosis were observed. The indices of oxidative stress decreased and those of antioxidative activity increased. The fatigue scale scores indicated lower scores except insomnia symptom. Taken together, detoxification profiles of Gamrosu were sufficiently feasible and the observed findings should be considered for further clinical studies.

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Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women

Cited by 30 publications

References 45 publications

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial

A Pilot Study to Develop Gamrosu, a Modified Fasting Therapy Beverage: Case Series

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