Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver

Minato, Ken-ichiro; Miyake, Yoichi; Fukumoto, Syuichi; Yamamoto, Kanefumi; Kato, Yoji; Shimomura, Yoshiharu; Osawa, Toshihiko

doi:10.1016/s0024-3205(02)02443-8

Cited by 117 publications

(98 citation statements)

References 21 publications

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“…Eriocitrin has been reported to have antioxidant activity 22 and a protective effect on oxidative damage in rat liver. 24 Eriodictyol (Fig. 2), an aglycone of eriocitrin, has been more commonly studied and is reported to inhibit the metabolism of the carcinogen benzo[a]pyrene by hamster embryo cells in tissue culture 25 as well as to possess 1,1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity.…”

Section: Resultsmentioning

confidence: 99%

Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

et al. 2006

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Section: Resultsmentioning

confidence: 99%

Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

et al. 2006

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“…Notably, eriodictyol is distributed in common foods and has been identified to have beneficial biological activities (19,20). Eriodictyol has been found to suppress nitric oxide production, NF-κB activation and mitogen-activated protein kinase phosphorylation in mouse macrophages (21).…”

Section: Introductionmentioning

confidence: 99%

Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

Zhu

Guo

Huang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Acute lung injury (ALI) is characterized by excessive inflammatory responses and oxidative injury in the lung tissue. It has been suggested that anti-inflammatory or antioxidative agents could have therapeutic effects in ALI, and eriodictyol has been reported to exhibit antioxidative and anti-inflammatory activity in vitro. The aim of the present study was to investigate the effect of eriodictyol on lipopolysaccharide (LPS)-induced ALI in a mouse model. The mice were divided into four groups: Phosphate-buffered saline-treated healthy control, LPS-induced ALI, vehicle-treated ALI (LPS + vehicle) and eriodictyol-treated ALI (LPS + eriodictyol). Eriodictyol (30 mg/kg) was administered orally once, 2 days before the induction of ALI. The data showed that eriodictyol pretreatment attenuated LPS-induced ALI through its antioxidative and anti-inflammatory activity. Furthermore, the eriodictyol pretreatment activated the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in the ALI mouse model, which attenuated the oxidative injury and inhibited the inflammatory cytokine expression in macrophages. In combination, the results of the present study demonstrated that eriodictyol could alleviate the LPS-induced lung injury in mice by regulating the Nrf2 pathway and inhibiting the expression of inflammatory cytokines in macrophages, suggesting that eriodictyol could be used as a potential drug for the treatment of LPS-induced lung injury.

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“…Eriocitrin has been reported to be the most abundant flavonoid in lemon fruit and to have the highest antioxidative activity of the flavonoids in citrus fruits in vitro (9,11). It was also shown to have a suppressive effect for oxidative stress in the liver of streptozotocin-induced diabetic rats (12) or exercise-induced rats (13).…”

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confidence: 99%

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

Miyake

Sakurai

Usuda

et al. 2006

J Nutr Sci Vitaminol

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SummaryThe concentrations of metabolites in human plasma after ingestion of flavanone glycosides (FG) and their aglycones (FA) in lemon were examined. FG consisting abundantly of eriocitrin were prepared from lemon peel and FA consisting abundantly of eriodictyol were prepared from FG by treatment with ␤-glucosidase. Eriodictyol, homoeriodictyol, and hesperetin in plasma up to 4 h after ingestion of FG with water or FA with water by subjects were not detected in plasma of non-enzyme treatment but in plasma after treatment with ␤-glucronidase and sulfatase. Metabolites in plasma after ingestion of FG and FA in humans were shown to exist as the glucuro-and/or sulfo-conjugates of eriodictyol, homoeriodictyol, and hesperetin. After ingestion of FA, the concentration of metabolites in plasma exhibited a high maximum peak at 1 h. The AUC (area under the blood concentration time curve) level of metabolites of FA was higher than that of FG. FA were suggested to be absorbed faster and in higher amounts than FG. The AUC of metabolites in subject plasma after ingestion of FG with flavonoid-depleted lemon juice was shown to change to a low level in comparison with that of FG with water. The maximum concentration peak of metabolites in plasma was faster at 0.5 h than FA with water but the AUC level was similar to FA with water, when subjects ingested FA with vodka (40% ethanol). The absorption hour of FG and FA was shown to be affected by the co-existing solution. Key Words lemon flavonoid, eriocitrin, plasma, human, ingestion Epidemiological studies indicate a protective relationship between the consumption of citrus fruits or juice and the risk of ischemic stroke and lung cancer (1, 2). Some fundamental studies support a protective effect provided by flavonoid consumption in these diseases (3-6). Citrus fruits contain various kinds of flavonoids such as flavanone glycoside, flavone glycoside, and polymethoxyflavone (3, 4). Flavonoids in lemon fruit (Citrus limon BURM. f.) have been reported to be such flavanone glycosides as eriocitrin (eriodictyol 7-O-␤-rutinoside) and hesperidin (hesperetin 7-O-␤-rutinoside) and such flavone glycosides as diosmin (diosmetin 7-O-␤-rutinoside) and 6,8 C-diglucosyldiosmetin (7-10). Eriocitrin has been reported to be the most abundant flavonoid in lemon fruit and to have the highest antioxidative activity of the flavonoids in citrus fruits in vitro (9,11). It was also shown to have a suppressive effect for oxidative stress in the liver of streptozotocin-induced diabetic rats (12) or exercise-induced rats (13).For the study of functional compounds such as flavonoids in foods, it is important to determine how the compounds in food are metabolized and absorbed in vivo and how the metabolites function in a living system. There have been several human studies that have investigated the metabolism and absorption of flavonoids (14), such as anthocyanin (15, 16), flavonol (17, 18), isoflavone (19), and flavanone (20-22). As for eriocitrin, it was reported for metabolites by human intestinal bacteri...

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Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver

Cited by 117 publications

References 21 publications

Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

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