Lenabasum Reduces Porphyromonas gingivalis–Driven Inflammation

Batool, Fareeha; Gegout, Pierre-Yves; Stutz, Céline; White, Barbara; Kolodziej, Andrew; Benkirane‐Jessel, Nadia; Petit, Catherine; Huck, Olivier

doi:10.1007/s10753-022-01658-5

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…ECS signalling has been found to upregulate resolvins, a family of lipid mediators that is described to promote resolution of several kinds of inflammation. [28][29][30] Resolvins have demonstrated various anti-inflammatory effects including to reduce human neutrophilic chemotaxis. 31,32 Additionally, both resolvins and endocannabinoids have been shown to reduce TRPV1-dependent acute pain and itch.…”

Section: Introductionmentioning

confidence: 99%

“…The ECS is known to play a significant role in immunoregulation, including a supportive role in decreasing peripheral autoinflammation. ECS signalling has been found to upregulate resolvins, a family of lipid mediators that is described to promote resolution of several kinds of inflammation 28–30 . Resolvins have demonstrated various anti‐inflammatory effects including to reduce human neutrophilic chemotaxis 31,32 .…”

Section: Introductionmentioning

confidence: 99%

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Nano‐encapsulated anandamide reduces inflammatory cytokines in vitro and lesion severity in a murine model of cutaneous lupus erythematosus

McCormick,

Draganski,

Chalmers

et al. 2023

Experimental Dermatology

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Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease which occurs independently and in conjunction with systemic lupus erythematosus. Drug development for CLE is severely lacking. Anandamide (AEA) is a primary endocannabinoid which exhibits immunomodulatory effects through mixed cannabinoid receptor agonism. We evaluated AEA as topical treatment for CLE and assessed benefits of nanoparticle encapsulation (AEA‐NP) on cutaneous drug penetration, delivery and biological activity. Compared to untreated controls, AEA‐NP decreased IL‐6 and MCP‐1 in UVB‐stimulated keratinocytes (p < 0.05) in vitro. In BALB/c mice, AEA‐NP displayed improved cutaneous penetration, extended release and persistence of AEA in the follicular unit extending to the base after 24 h. Utilizing the MRL‐lpr lupus murine model, twice weekly treatment of lesions with topical AEA‐NP for 10 weeks led to decreased clinical and histologic lesion scores compared to unencapsulated AEA and untreated controls (p < 0.05). Prophylactic application of AEA‐NP to commonly involved areas on MRL‐lpr mice similarly resulted in decreased clinical and histologic scores when compared to controls (p < 0.05), and reduced C3 and IBA‐1 in lesional tissue (p < 0.05). The demonstrated clinical and immunomodulatory effects of treatment with AEA support its potential as therapy for CLE. This work also suggests that encapsulation of AEA improves penetration and treatment efficacy. Future studies will be conducted to assess full therapeutic potential.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nano‐encapsulated anandamide reduces inflammatory cytokines in vitro and lesion severity in a murine model of cutaneous lupus erythematosus

McCormick,

Draganski,

Chalmers

et al. 2023

Experimental Dermatology

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“…5-hydroxy-4-(3-methylbutanoyl)-2,6,6-tris(3-methylbut-2-enyl)cyclohex-4-ene-1,3-dione has antibacterial property [13], compounds like 5-epi-Callystatin A, 2-hydroxyethaneperoxoic acid, 5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione are known to have anticancer effect [12] [40] [10]. Antioxidant property was detected for compounds like 5,6-dihydroxy-1,1-dimethyl-7-(propan-2yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic acid and 1,2-benzene dicarboxylic acid [35] [24] whereas anti-in ammatory activity was observed in 1',1'-Dimethylheptyl-delta-8tetrahydrocannabinol-11-oic acid [5]. Additionally, FTIR analysis of the extracted metabolites serve as a con rmatory result for the corresponding functional groups like -O-H, -C-Cl, -CH2, -C = O, C-Br of the chemical compounds obtained in GC-MS analysis.…”

mentioning

confidence: 99%

Dimethoate degrading efficiency of Bacillus paramycoides isolated from pesticide influenced rhizospheric soil of sugarcane field in Tamil Nadu

Sur

Sathiavelu

2023

Preprint

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Pesticides are inevitable part of Indian agriculture. Statistically, India is one of the top producer of pesticide over the world. As a developing country, abundance use of pesticide is quite common and organophosphates (OPP) being one of them. Known for causing acute toxicity, OPPs are needed to be used controllably and residues released into the environment should be treated to render harmless. Biological degradation is one of the effective ways to achieve that. However, exploring potential candidate for the purpose is still not sufficient compared to the necessity to alleviate OPP from environment. In this study, dimethoate, a subclass of OPP has been studied for microbial degradation using bacteria Bacillus paramycoides, isolated from rhizospheric soil of sugarcane cultivation fields pre-exposed to pesticide dimethoate for considerable long time. The strain has been extensively studied to check its prospect on environmental stress, pesticide tolerance and degradation efficiency. The isolate was found to degrade dimethoate by 97.6% in 5 days with a tolerance of 1000ppm of targeted pesticide. Emphasis have also been made to detect the secondary metabolites produced by the isolate using GCMS analysis and the functional groups were confirmed by FTIR. Significant biologically important metabolites obtained from B.paramycoides were also reported in this study which are known to have having anticancerous, antibacterial properties. This work presumably is the first communication prospecting B.paramycoides for dimethoate degradation.

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The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation

Stutz,

Gegout,

Bloch

et al. 2024

BMC Oral Health

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Lenabasum Reduces Porphyromonas gingivalis–Driven Inflammation

Cited by 3 publications

References 38 publications

Nano‐encapsulated anandamide reduces inflammatory cytokines in vitro and lesion severity in a murine model of cutaneous lupus erythematosus

Nano‐encapsulated anandamide reduces inflammatory cytokines in vitro and lesion severity in a murine model of cutaneous lupus erythematosus

Dimethoate degrading efficiency of Bacillus paramycoides isolated from pesticide influenced rhizospheric soil of sugarcane field in Tamil Nadu

The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation

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