Lenfoma hastalarında yetersiz hematopoiteik kök hücre mobilizasyonu için risk faktörleri

Abstract

Aim: Poor mobilization is an important problem in autologous stem cell transplantation. The ratio of poor mobilization is higher in lymphoma patients. There is limited data about poor mobilization in lymphoma patients. We aimed to identify the possible risk factors for poor mobilization using data from 57 lymphoma patients. Materials and Methods:We retrospectively reviewed the data of 57 lymphoma patients (40 with non-Hodgkin lymphoma and 17 with Hodgkin lymphoma) who have been mobilized during 1998 -2011. Patient data were recruited from the archives of the hematology clinic. Results:We documented poor mobilization in 13 (22.8%) patients. Bone marrow involvement (odds ratio [OR] =15.52, p=0.002) and being treated with more than ten cycles of chemotherapies (OR=6.25, p=0.04) were found to be possible risk factors. Conclusion:Leukapheresis staff should be aware of the increased risk of poor mobilization in these cases and remobilization strategies should be considered from the beginning in these patients with risk factors for more effective resource utilization.Keywords: Hematopoietic stem cell mobilization, lymphoma, poor mobilization, risk factors. Öz