Length at Birth and Effect of Prenatal and Postnatal Factors on early Wheezing Phenotypes. Kraków Epidemiologic Cohort Study

Jędrychowski, Wiesław; Perera, Frederica P.; Maugeri, U; Mróz, Elżbieta; Mrozek-Budzyn, Dorota; Edwards, SJ; Musiał, Agnieszka

doi:10.2478/v10001-008-0013-0

Cited by 5 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Longer birth length was associated with a lower rate of asthma, potentially related to larger airway caliber at birth, and is consistent with recent studies demonstrating a lower risk of persistent wheezing among children with longer length at birth 29 and lower risk of asthma at age 10 years among children with longer first-trimester fetal size. 30 …”

Section: Discussionsupporting

confidence: 90%

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Bacharier

Cohen

Schweiger

et al. 2012

Journal of Allergy and Clinical Immunology

235

240

View full text Add to dashboard Cite

Background The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.

show abstract

Section: Discussionsupporting

confidence: 90%

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Bacharier

Cohen

Schweiger

et al. 2012

Journal of Allergy and Clinical Immunology

235

240

View full text Add to dashboard Cite

show abstract

“…As this classification is based on retrospective symptom history at the age of 6, it cannot be used to guide treatment decisions for younger children. However, it has become the most widely used model in epidemiological studies [25,[43][44][45][46][75][76][77][78][79][80][81][82].…”

Section: The One-dimensional Approachmentioning

confidence: 99%

Phenotypes of childhood asthma: are they real?

Spycher¹,

Silverman²,

Kuehni³

2010

Clin Experimental Allergy

108

View full text Add to dashboard Cite

It has been suggested that there are several distinct phenotypes of childhood asthma or childhood wheezing. Here, we review the research relating to these phenotypes, with a focus on the methods used to define and validate them. Childhood wheezing disorders manifest themselves in a range of observable (phenotypic) features such as lung function, bronchial responsiveness, atopy and a highly variable time course (prognosis). The underlying causes are not sufficiently understood to define disease entities based on aetiology. Nevertheless, there is a need for a classification that would (i) facilitate research into aetiology and pathophysiology, (ii) allow targeted treatment and preventive measures and (iii) improve the prediction of long-term outcome. Classical attempts to define phenotypes have been one-dimensional, relying on few or single features such as triggers (exclusive viral wheeze vs. multiple trigger wheeze) or time course (early transient wheeze, persistent and late onset wheeze). These definitions are simple but essentially subjective. Recently, a multi-dimensional approach has been adopted. This approach is based on a wide range of features and relies on multivariate methods such as cluster or latent class analysis. Phenotypes identified in this manner are more complex but arguably more objective. Although phenotypes have an undisputed standing in current research on childhood asthma and wheezing, there is confusion about the meaning of the term 'phenotype' causing much circular debate. If phenotypes are meant to represent 'real' underlying disease entities rather than superficial features, there is a need for validation and harmonization of definitions. The multi-dimensional approach allows validation by replication across different populations and may contribute to a more reliable classification of childhood wheezing disorders and to improved precision of research relying on phenotype recognition, particularly in genetics. Ultimately, the underlying pathophysiology and aetiology will need to be understood to properly characterize the diseases causing recurrent wheeze in children.

show abstract

“…[4][5][6] A variety of factors, such as day care attendance, 7,8 older siblings 7,9,10 and lack of breastfeeding, [10][11][12] have been considered as possible risk factors for early respiratory tract infections. In addition, a parental history of asthma 13,14 and smoking 10,[15][16][17][18] are thought to have a role in the child' s susceptibility to infections and to respiratory symptoms. Earlier reports on the role of animal contacts on the prevalence of respiratory tract infections are sparse.…”

mentioning

confidence: 99%

Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Bergroth¹,

Remes²,

Pekkanen

et al. 2012

Pediatrics

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Respiratory infectious symptoms are common during the first year of life. Day care attendance, older siblings, and lack of breastfeeding have been considered as possible factors influencing early respiratory tract infections. WHAT THIS STUDY ADDS:Children with early dog contacts seem to have fewer infectious respiratory symptoms and diseases, especially otitis, during the first year of life. abstract OBJECTIVES: To investigate the effect of dog and cat contacts on the frequency of respiratory symptoms and infections during the first year of life. METHODS:In this birth cohort study, 397 children were followed up from pregnancy onward, and the frequency of respiratory symptoms and infections together with information about dog and cat contacts during the first year of life were reported by using weekly diaries and a questionnaire at the age of 1 year. All the children were born in eastern or middle Finland between September 2002 and May 2005. RESULTS:In multivariate analysis, children having dogs at home were healthier (ie, had fewer respiratory tract symptoms or infections) than children with no dog contacts (adjusted odds ratio, [aOR]: 1.31; 95% confidence interval [CI]: 1.13-1.52). Furthermore, children having dog contacts at home had less frequent otitis (aOR: 0.56; 95% CI: 0.38-0.81) and tended to need fewer courses of antibiotics (aOR: 0.71; 95% CI: 0.52-0.96) than children without such contacts. In univariate analysis, both the weekly amount of contact with dogs and cats and the average yearly amount of contact were associated with decreased respiratory infectious disease morbidity. CONCLUSIONS:These results suggest that dog contacts may have a protective effect on respiratory tract infections during the first year of life. Our findings support the theory that during the first year of life, animal contacts are important, possibly leading to better resistance to infectious respiratory illnesses during childhood. Pediatrics 2012;130:211-220 AUTHORS:

show abstract

Length at Birth and Effect of Prenatal and Postnatal Factors on early Wheezing Phenotypes. Kraków Epidemiologic Cohort Study

Cited by 5 publications

References 44 publications

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Phenotypes of childhood asthma: are they real?

Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Contact Info

Product

Resources

About