Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity

Poland, Craig A.; Byrne, Fiona; Cho, Wan‐Seob; Prina-Mello, Adriele; Murphy, Fiona; Davies, G. R.; Coey, J. M. D.; Gounko, Yurii; Duffin, Rodger; Volkov, Yuri; Donaldson, Kenneth

doi:10.3109/17435390.2011.626535

Cited by 73 publications

(61 citation statements)

References 29 publications

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“…Further, a significant difference in inflammatory response in a mouse peritoneal model was observed between Ni NWs of 4.3 µm and 24 µm in length (Poland et al 2012).…”

Section: Introductionmentioning

confidence: 90%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

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The assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.Just Accepted by Nanotoxicology © 2015 Taylor & Francis. This provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.DISCLAIMER: The ideas and opinions expressed in the journal's Just Accepted articles do not necessarily reflect those of Taylor & Francis (the Publisher), the Editors or the journal. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of the material contained in these articles. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosages, the method and duration of administration, and contraindications. It is the responsibility of the treating physician or other health care professional, relying on his or her independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Just Accepted articles have undergone full scientific review but none of the additional editorial preparation, such as copyediting, typesetting, and proofreading, as have articles published in the traditional manner. There may, therefore, be errors in Just Accepted articles that will be corrected in the final print and final online version of the article. Any use of the Just Accepted articles is subject to the express understanding that the papers have not yet gone through the full quality control process prior to publication. Cytotoxicity and intracellular dissolution of nickel nanowiresJose E. Perez 1, 2 , Maria F. Contreras 1 , Enrique Vilanova 2 , Laura P. Felix 1, 2 , Michael B.

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“…Further, a significant difference in inflammatory response in a mouse peritoneal model was observed between Ni NWs of 4.3 µm and 24 µm in length (Poland et al 2012).…”

Section: Introductionmentioning

confidence: 90%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

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“…In addition to work on biological and biomedical applications, fundamental studies involving internalization into different cell lines, 34 the dependence of cytotoxicity on incubation time and NW concentration, 33,34 and length-dependent cytotoxicity 35 have been reported. Moreover, cellular processes such as increased levels of reactive oxygen species, 27 cell viability reduction, 27,36 and cell membrane leakage 36 have been shown to be activated solely by the incubation of cells with Ni NWs.…”

mentioning

confidence: 99%

Non-chemotoxic induction of cancer cell death using magnetic nanowires

Contreras¹,

Sougrat²,

Zaher³

et al. 2015

IJN

102

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In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods.

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“…Recently, NiONPs were taken up by kidney cell line and induced dose-dependent DNA damage and apoptotic/nephritic effects [18]. Reference [30] studied the effects intraperitoneal injection and aspiration effects of nickel nanowire with diameter of 200 nm and length of more than 20 lm in mice and found out that they caused strong inflammation in mouse peritoneal cavity and lung respectively, in a dose-dependent manner. Nanoparticles were also found to up-regulate the transcription of various pro-inflammatory genes, including tumor necrosis factor-α and IL (interleukins)-1, IL-6 and IL-8, by activating nuclear factor-kappa B (NF-κB) signaling.…”

Section: Resultsmentioning

confidence: 99%

Nephrotoxicity of nickel nanoparticles in rat: Effect of different doses

2018

CBEMS-18,DMCCIA-18,EHSSM-18,BLEIS-18,ICLTET-18 March 21-23, 2018 Istanbul (Turkey)

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Abstract-The present investigation was dealt with the study of the effect of different doses of Nickel nanoparticles (NiNPs) (particle size equal to 20nm) on the kidney of rat. Intraperitoneal administration of NiNPs (0,5,10,20, 50 and 100mg/kg bw) was achieved for 28 days and the kidney samples were homogenized to estimate the level of malondialdehyde (MDA) as lipid peroxidation marker while creatinine was estimated in serum as well as studying the histopathological changes. Significant dose dependent elevation of MDA in kidney homogenate and a significant dose dependent increase of serum creatinine were detected. The most histopathological feature was the appearance of inflammatory aggregations of infiltrated leucocytes.

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Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity

Cited by 73 publications

References 29 publications

Cytotoxicity and intracellular dissolution of nickel nanowires

Cytotoxicity and intracellular dissolution of nickel nanowires

Non-chemotoxic induction of cancer cell death using magnetic nanowires

Nephrotoxicity of nickel nanoparticles in rat: Effect of different doses

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