Length of Gestation in Mice Under a 21-Hour Day

Lanman, Jonathan T.; Seidman, Linda S.

doi:10.1095/biolreprod17.2.224

Cited by 17 publications

(6 citation statements)

References 1 publication

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“…Moreover, rats on a 24 hr day gave birth to the greatest proportion oflitters in the light period; but those on a 22 hr day gave birth mainly in the dark (P < 0-01). These results differ from those obtained by Lanman & Seidman (1977) who found no change in the length of pregnancy in mice subjected to a 21 hr day. The results also contrast with the findings of Lincoln & Porter (1976) who subjected pregnant rats to shifts in the onset ofthe light and dark periods and found that birth still tended to occur in the light period.…”

contrasting

confidence: 99%

Proceedings of the Physiological Society, 16‐18 June 1983, Cambridge Meeting: Babraham Poster Communications

1983

The Journal of Physiology

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contrasting

confidence: 99%

Proceedings of the Physiological Society, 16‐18 June 1983, Cambridge Meeting: Babraham Poster Communications

1983

The Journal of Physiology

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“…Parturition in C57bl/6 mice normally occurs 19.5 days after identification of a vaginal plug with little variation if the timing of mating is accurate [26]. However, it is important to note that pregnancy nomenclature varies by laboratory; thus, within the literature, identification of the vaginal plug has been denoted E0, E0.5 or E1 with term pregnancy occurring on E19.5, E20 or E20.5, respectively.…”

Section: Methodsmentioning

confidence: 99%

Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations

Bruner‐Tran

Osteen

2011

Reproductive Toxicology

153

155

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TCDD (2,3,7,) is a ubiquitous environmental contaminant and known endocrine disruptor. Since humans and animals are most sensitive to toxicant exposure during development, we previously developed a mouse model of in utero TCDD exposure in order to examine the impact of this toxicant on adult reproductive function. Our initial in utero toxicantexposure study revealed a dose-dependent reduction in uterine sensitivity to progesterone; however, we did not previously explore establishment or maintenance of pregnancy. Thus, in the current study, we examined pregnancy outcomes in adult C57BL/6 mice with a history of developmental TCDD exposure. Herein we demonstrate reduced fertility and an increased incidence of premature birth (PTB) in F1 mice exposed in utero to TCDD as well as in three subsequent generations. Finally, our studies revealed that mice with a history of developmental TCDD exposure exhibit an increased sensitivity to inflammation which further negatively impacted gestation length in all generations examined.

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“…Parturition in C57BL/6 mice normally occurs 19.5 days after identification of a vaginal plug, with little variation if the timing of mating is accurate [41]. However, it is important to note that pregnancy nomenclature varies by laboratory; thus, within the literature, identification of the vaginal plug has been denoted E0, E0.5 or E1 with term pregnancy occurring on E19.5, E20 or E20.5, respectively.…”

Section: Methodsmentioning

confidence: 99%

Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice

Ding

McConaha

Boyd

et al. 2011

Reproductive Toxicology

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We have previously described diminished uterine progesterone response and increased uterine sensitivity to inflammation in adult female mice with a history of developmental exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). Since parturition in mammals is an inflammatory process mediated in part by a decline in progesterone action, toxicant-mediated disruption of progesterone receptor (PR) expression at the maternal-fetal interface would likely impact the timing of birth. Therefore, in the current study, we examined pregnancy outcomes in adult female mice with a similar in utero exposure to TCDD. We also examined the impact of in utero TCDD exposure of male mice on pregnancy outcomes in unexposed females since the placenta, a largely paternally derived organ, plays a major role in the timing of normal parturition via inflammatory signaling. Our studies indicate that developmental exposure of either parent to TCDD is associated with preterm birth in a subsequent adult pregnancy due to altered PR expression and placental inflammation.

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Length of Gestation in Mice Under a 21-Hour Day

Cited by 17 publications

References 1 publication

Proceedings of the Physiological Society, 16‐18 June 1983, Cambridge Meeting: Babraham Poster Communications

Proceedings of the Physiological Society, 16‐18 June 1983, Cambridge Meeting: Babraham Poster Communications

Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations

Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice

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