Lennox–Gastaut syndrome in south Iran: Electro-clinical manifestations

Asadi‐Pooya, Ali A.; Sharifzade, Mohaddese

doi:10.1016/j.seizure.2012.08.003

Cited by 29 publications

(27 citation statements)

References 27 publications

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“…Through the search strategy, we could identify 16 related articles (Table 1). 9–24 Another article was retrieved from other sources 25 . Table 2 shows the summary of these 17 studies 9–25 .…”

Section: Resultsmentioning

confidence: 99%

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Epilepsy syndromes in Iran: A systematic review

Asadi‐Pooya

Simani

2020

Acta Neurol Scand

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This study aimed to systematically review the literature on the epidemiology of epilepsy in Iran and to provide analytical estimates of the prevalence of various epilepsy syndromes. MEDLINE, Scopus, and Embase from inception to 30 July 2020 were systematically searched. These key words were used: “epilepsy” OR “seizure” AND “Iran.” In the second part of the study, the prevalence of various epilepsy syndromes in Iran was estimated based on the data from previous studies. We could identify 17 related articles. Three studies had class 2, and the rest provided class 4 of evidence. Two population‐based studies provided the prevalence rate of epilepsy in Iran: 0.8% and 1.2%. In one clinic‐based study, 20.2% of the patients were diagnosed as having idiopathic generalized epilepsy (IGE). In another clinic‐based study, 5.4% of the patients were diagnosed to have Lennox‐Gastaut syndrome. No study has provided data on focal epilepsy syndromes other than temporal lobe epilepsy (TLE) in Iran. While high‐quality data from Iran on the epidemiology of epilepsy syndromes are scarce, based on the available data and extrapolations form other data from other world regions, we can estimate that the prevalence of epilepsy in Iran is about 1% and about 840,000 people currently have active epilepsy. From the whole population of people with epilepsy in Iran, about 168,000 people have IGEs, tens of thousands suffer from symptomatic generalized epilepsies, and approximately, 126,000–226,800 people suffer from TLE. There is a need for well‐designed population‐based epidemiological studies on the topic.

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Section: Resultsmentioning

confidence: 99%

“… 9–24 Another article was retrieved from other sources 25 . Table 2 shows the summary of these 17 studies 9–25 . Three studies provided level 2 of evidence (ecological studies), 15,17,18 and the rest provided level 4 of evidence (case‐series or superseded reference standards).…”

Section: Resultsmentioning

confidence: 99%

Epilepsy syndromes in Iran: A systematic review

Asadi‐Pooya

Simani

2020

Acta Neurol Scand

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“…For example, nuclear magnetic spectroscopy (MRS) and positron emission tomography (PET) may be useful in identifying underlying metabolic disorders in patients with clinical features of Lennox-Gastaut syndrome but normal MRI. 21(pp2,4,5) ,22(p762),23 Psychological testing should also be conducted at baseline and repeated intermittently throughout the patient’s life to track developmental changes. 20…”

Section: Early Recognition Of Lennox-gastaut Syndrome Patterns and Evmentioning

confidence: 99%

Early Diagnosis and Treatment of Lennox-Gastaut Syndrome

Resnick

2017

J Child Neurol

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Lennox-Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy associated with high morbidity and mortality. The peak period for manifestations of Lennox-Gastaut syndrome is between ages 3 and 5 years, a time of critical brain development and corresponding vulnerability to the electroclinical dysfunction arising from Lennox-Gastaut syndrome. Diagnosis is based on a triad of symptoms: multiple seizure types, cognitive impairment, and slow spike-and-wave pattern on electroencephalography. In practice, Lennox-Gastaut syndrome presentation is diverse, and there may be a delay between initial symptoms and emergence of the full triad of clinical features. Additionally, differential diagnosis is complicated by the resemblance of Lennox-Gastaut syndrome to other forms of epilepsy and by the need for varied diagnostic techniques requiring specific clinical skills. Because diagnosis is complex and early intervention may lead to improved outcomes, clinicians should consider treatment when Lennox-Gastaut syndrome symptoms are present, even in the absence of a formal diagnosis.

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“…West Syndrome typically begins in the first year of life, usually between 3 and 8 months [87]. Epileptic spasms, tonic, atonic, generalized tonic-clonic, and myoclonic seizures are common.…”

Section: Epilepsy In Childrenmentioning

confidence: 99%

Marijuana Compounds: A Non-Conventional Therapeutic Approach to Epilepsy in Children

Babayeva¹

2014

AAD

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Lennox–Gastaut syndrome in south Iran: Electro-clinical manifestations

Cited by 29 publications

References 27 publications

Epilepsy syndromes in Iran: A systematic review

Epilepsy syndromes in Iran: A systematic review

Early Diagnosis and Treatment of Lennox-Gastaut Syndrome

Marijuana Compounds: A Non-Conventional Therapeutic Approach to Epilepsy in Children

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