Lens based adaptive optics scanning laser ophthalmoscope

Felberer, Franz; Kroisamer, Julia S.; Hitzenberger, Christoph K.; Pircher, Michael

doi:10.1364/oe.20.017297

Cited by 37 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternative techniques to reduce back reflection from the lenses that could be used in the next phase of this research include a confocal pinhole, 41 or polarization optics. 42 Compared to what has been reported in the literature, 17 the defocus term measured in our study with the AO-OFF [presented in Fig. 2(e) as the 4th coefficient of the Zernike polynomial] does not represent the refractive power of the mouse eye, but rather the displacement of the retina relative to the focal plane of the objective.…”

Section: Discussionmentioning

confidence: 52%

Adaptive optics optical coherence tomography forin vivomouse retinal imaging

2013

View full text Add to dashboard Cite

Abstract. Small animal models of retinal diseases are important to vision research, and noninvasive high resolution in vivo rodent retinal imaging is becoming an increasingly important tool used in this field. We present a custom Fourier domain optical coherence tomography (FD-OCT) instrument for high resolution imaging of mouse retina. In order to overcome aberrations in the mouse eye, we incorporated a commercial adaptive optics system into the sample arm of the refractive FD-OCT system. Additionally, a commercially available refraction canceling lens was used to reduce lower order aberrations and specular back-reflection from the cornea. Performance of the adaptive optics (AO) system for correcting residual wavefront aberration in the mice eyes is presented. Results of AO FD-OCT images of mouse retina acquired in vivo with and without AO correction are shown as well. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Section: Discussionmentioning

confidence: 52%

Adaptive optics optical coherence tomography forin vivomouse retinal imaging

2013

View full text Add to dashboard Cite

show abstract

“…The used instrument is a lens based AO-SLO [45] in combination with en-face OCT. Details of the system have been presented previously [44].…”

Section: Methodsmentioning

confidence: 99%

Imaging of retinal vasculature using adaptive optics SLO/OCT

Felberer

Rechenmacher

Haindl

et al. 2015

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

Abstract:We use our previously developed adaptive optics (AO) scanning laser ophthalmoscope (SLO)/ optical coherence tomography (OCT) instrument to investigate its capability for imaging retinal vasculature. The system records SLO and OCT images simultaneously with a pixel to pixel correspondence which allows a direct comparison between those imaging modalities. Different field of views ranging from 0.8°x0.8° up to 4°x4° are supported by the instrument. In addition a dynamic focus scheme was developed for the AO-SLO/OCT system in order to maintain the high transverse resolution throughout imaging depth. The active axial eye tracking that is implemented in the OCT channel allows time resolved measurements of the retinal vasculature in the en-face imaging plane. Vessel walls and structures that we believe correspond to individual erythrocytes could be visualized with the system.

show abstract

“…9.1 ). Adaptive optics increase transverse resolution and allow each photoreceptor variation to be analyzed, for example, for toxic effects of the intra-and subretinal fl uid of the CNVs [ 6 ]. Swept-source imaging speeds image acquisition up to approximately 100,000-350,000 A-scans/sec compared with the 25,000-55,000 A-scans/sec of the SD-OCT devices most commonly used in the clinic today [ 7 , 8 ].…”

Section: Sd-oct In Namdmentioning

confidence: 99%