We study a quantum (non-commutative) representation of the affine Weyl group mainly of type E(1) 8 , where the representation is given by birational actions on two variables x, y with q-commutation relations. Using the tau variables, we also construct quantum "fundamental" polynomials F (x, y) which completely control the Weyl group actions. The geometric properties of the polynomials F (x, y) for the commutative case is lifted distinctively in the quantum case to certain singularity structures as the q-difference operators. This property is further utilized as the characterization of the quantum polynomials F (x, y). As an application, the quantum curve associated with topological strings proposed recently by the first named author is rederived by the Weyl group symmetry. The cases of type D(1)5 , E