Lens opacity in unilateral exfoliation syndrome with or without glaucoma

Puska, Päivi

doi:10.1111/j.1755-3768.1994.tb02761.x

Cited by 26 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In PE+ eyes, we also confirmed a significantly higher IOP and lower MD values suggested the presence of severer glaucoma [22], poorer logMAR VA suggested progressed cataract [23], higher ACF suggested blood-aqueous barrier breakdown[24, 25] and lower CECD suggested keratopathy [26] in PE+ eyes as reported previously.…”

Section: Discussionsupporting

confidence: 88%

Comparisons of retinal vessel diameter and glaucomatous parameters between both eyes of subjects with clinically unilateral pseudoexfoliation syndrome

et al. 2017

View full text Add to dashboard Cite

PurposePseudoexfoliation syndrome (PEX), the most common identifiable cause of open-angle glaucoma, might affect the retinal hemodynamics. To test this, we compared retinal vessel diameter and glaucoma-related parameters between eyes with pseudoexfoliation material (PE+) and fellow unaffected (PE-) eyes of patients with clinically unilateral PEX.MethodsThe medical records of 30 consecutive Japanese subjects were reviewed retrospectively. The retinal vessel diameters were measured and expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) using standardized software. During the chart review, we recorded glaucoma-related parameters including intraocular pressure (IOP), visual field mean deviation (MD) value, planimetrically measured vertical cup-to-disc (C/D) ratio, circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular inner retinal thickness (mIRT) measured by spectral-domain optical coherence tomography, anterior chamber flare (ACF), corneal endothelial cell density (CECD), and number of antiglaucoma medications.ResultsCompared with PE- eyes, the CRAE, CRVE, MD, cpRNFLT and mIRT, and CECD were significantly lower in PE+ eyes; the IOP, vertical C/D ratio, number of antiglaucoma medications, and ACF were significantly higher in PE+ eyes (P<0.0001 for all comparisons). The CRAE, cpRNFLT, and MD were correlated positively with each other (ρ = 0.456–0.499, P<0.0001–0.0002) and negatively with the IOP (ρ = -0.562- —0.432, P<0.0001–0.0006). The vertical C/D ratio was correlated positively with the IOP (ρ = 0.483, P<0.0001) and negatively with the CRAE, cpRNFLT, and MD (ρ = -0.745–-0.479, P<0.0001–0.0001).ConclusionsDeposition of PE can cause retinal vessel narrowing in arterioles and venules. The roles and mechanisms of retinal vessel narrowing in glaucoma pathogenesis need clarification.

show abstract

Section: Discussionsupporting

confidence: 88%

Comparisons of retinal vessel diameter and glaucomatous parameters between both eyes of subjects with clinically unilateral pseudoexfoliation syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In addition to these changes observed on the lens capsule, the incidence of cataract formation is increased in patients with PXF. 40,[49][50][51][52][53][54][55][56][57][58][59] A higher percentage of nuclear opacities has been observed in PXF eyes and the affected eye of individuals with uniocular PXF often demonstrate the more advanced cataract. 54,57,58 The occurrence of cataract may simply be a consequence of the increased age of individuals with PXF as no causal link has been established.…”

Section: Lensmentioning

confidence: 99%

The Medical and Surgical Management of Pseudoexfoliation Glaucoma

Desai

Lee

2008

International Ophthalmology Clinics

View full text Add to dashboard Cite

Pseudoexfoliation (PXF) glaucoma is classically diagnosed by slit lamp visualization of white powdery deposits (PXF material) in a bull's eye configuration on the lens capsule. PXF glaucoma is the most common form of open-angle worldwide with an identifiable etiology. 1 The presence of PXF material is associated with an increased risk of developing glaucoma, but can be present in the eye without associated glaucoma. This disorder also has an association with narrow angles secondary to zonular weakness, increased rate and risk of cataract formation, and increased risk of complications during cataract extraction associated with zonular dehiscence. PXF glaucoma's primary manifestations and morbidity are ocular. However, PXF is a systemic condition with PXF material present throughout the body. The presence of PXF material has been weakly associated with cardiovascular and cerebrovascular morbidity and sensorineural hearing loss. 2-10 Unlike PXF and glaucoma, a direct cause-effect relationship remains to be clearly established between the presence of PXF material and the aforementioned systemic associations. PXF syndrome was first described by Lindbergh in the year 1917, followed by Vogt, and initially termed "glaucoma capsulare." The classic white flaky dandrufflike material was initially thought to originate from the lens capsule. 11 Immunohistologic and electron microscopy studies suggest the PXF material deposited on the lens capsule and throughout the anterior segment of the eye (ie, the angle, corneal endothelium, etc.) is a product of abnormal extracellular matrix material metabolism. 1 PXF is distinct from true exfoliation syndrome observed in glass blowers, where a schisis of the anterior lens capsule occurs. Recent molecular and genetic studies have revealed clues as to the molecular pathogenesis of PXF material formation and the association of PXF with the extracellular matrix and cellular metabolism. 12,13 This paper reviews current concepts in the medical and surgical management of PXF glaucoma.

show abstract

“…And opposite, PXF prevalence in eyes with cataract was found 24.2% and in eyes without cataract 15.5% (Andrikopoulos, 2009). Eyes with PXF have been found with poorer visual acuity and more often lens opacification than clinically uninvolved fellow eyes (Puska, 1994). Cataract formation may be related to ocular ischemia, aqueous hypoxia, reduced protection against ultraviolet radiation, increased growth factor levels and oxidative stress.…”

Section: Pseudoexfoliation Syndrome and Cataract Formationmentioning

confidence: 99%