1999
DOI: 10.1046/j.1432-0436.1999.6430143.x
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Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression

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Cited by 29 publications
(39 citation statements)
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“…4; like example VII in Fig. 1D; Schaefer et al, 1999;Mizuno et al, 1999a). Understandably, XProx1, thought to be involved in the differentiation of mature lens fiber cells, is also first expressed at this time (Schaefer et al, 1999;Mizuno et al, 1999b;Wigle et al, 1999).…”
Section: Examining the Model Of Embryonic Lens Inductionmentioning
confidence: 86%
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“…4; like example VII in Fig. 1D; Schaefer et al, 1999;Mizuno et al, 1999a). Understandably, XProx1, thought to be involved in the differentiation of mature lens fiber cells, is also first expressed at this time (Schaefer et al, 1999;Mizuno et al, 1999b;Wigle et al, 1999).…”
Section: Examining the Model Of Embryonic Lens Inductionmentioning
confidence: 86%
“…library was obtained from corneas collected 1-4 days after lens removal. ␥-cry mRNA is first detected in transdifferentiating corneas on the fourth day after lens removal (Schaefer et al, 1999; see also Mizuno et al, 1999a).…”
Section: A Profile Of Gene Expression In Transdifferentiating Cornea mentioning
confidence: 95%
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“…the inner layer of the outer cornea deriving from the head ectoderm. Thus, in contrast to the case of the newt, lens regeneration in Xenopus is essentially a repeat of that which happens during ontogeny, although some differences in the sequence of crystallin gene expression were noted (Mizuno et al, 1999).…”
Section: Different Cell Lineages Leading To Lens Developmentmentioning
confidence: 96%
“…Must they acquire the same state as the head ectoderm prior to lens induction, or is there a shortcut that the dedifferentiating iris cells use to make a lens? The published evidence suggests that although there are many similarities between the temporo-spatial expression of genes during lens induction and regeneration, there are also differences, indicating that the two processes are not identical (Mizuno et al, 2002;Mizuno et al, 1999). One intriguing possibility is that during transdifferentiation the cells assume a state that is identical, or very similar, to the state of embryonic stem (ES) cells.…”
Section: Ectopic Lens Formationmentioning
confidence: 99%