Lens thickness of Indian eyes: impact of isolated lens opacity, age, axial length, and influence on anterior chamber depth

Abstract

Purpose To report relationship of age group and axial length (AL) category to lens thickness values in eyes with a clear lens or different types of isolated cataract (nuclear, cortical, and posterior subcapsular (PSC)). Further, we evaluated lens thickness values on anterior chamber depth (ACD) in these eyes. Design Observational clinic-based study. Methods An observational study of 1442 eyes of 1442 individuals (816 eyes with isolated cataract and 626 eyes with clear lens) of those above 25 years of age was evaluated. AL and lens thickness were performed with an A-scan ultrasound after dilatation of the pupil, and manual optical pachymetry was used to measure ACD after dilatation of the pupil. Main outcome measures: Lens thickness. Results Multiple regression analysis revealed that with each decade of advancement in age, the lens thickness increased by 0.155 mm (Po0.001). The difference in lens thickness after adjusting for age group and AL category was less in cortical cataract by À0.25 mm (Po0.001) and PSC by À0.29 mm (Po0.001); With advancement in AL category, lens thickness decreased by 0.004 mm (Po0.001). After adjusting for all the parameters/variables, regression analysis revealed that as lens thickness increased, there was a significant decrease in ACD (mean À0.44 mm; Po0.001). Conclusions Lens thickness was significantly greater in clear lenses when compared with isolated cataractsFgreatest with nuclear cataract and least with PSC. Age group and AL category had a significant impact on the lens thickness of both cataract and clear lens. A significant decrease in ACD was found with the increase in lens thickness.

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

“…The close correlation between LV and ACV found this time was in accordance with these. Praveen et al [26] reported that the lens thickness increased markedly in subjects aged 41–50 years, and this might account for the greater reductions in ACV and ACD in subjects aged 41–50 years in our study. A decrease in ACW with age was also found in our study.…”

The distribution of axial length, anterior chamber depth, lens thickness, and vitreous chamber depth in an adult population of Shahroud, Iran

“…The increase in LT with age can be attributed to the increase in protein fiber layers forming under the capsule. As mentioned, the ACD decreases with age, and in this regard, the increase in LT can be the main cause for the decrease in ACD, and this has been stated in the report by Praveen et al [29]. …”

Oxidative Damage and the Prevention of Age-Related Cataracts

“…The risk of nuclear cataracts increases with the amount and duration of smoking, adding confidence to the existence of a causal relationship between smoking and nuclear opacities. Two studies from diverse ethnic groups identified larger lens size as a risk factor for nuclear cataracts [15,16] . Longitudinal studies showed that having a larger lens conferred increased risk of developing nuclear opacities over a 5-year follow-up period [17] .…”

“…As with nuclear cataracts, lens size was identified as a significant risk factor for cortical cataracts. However, unlike nuclear cataracts, the increased prevalence and incidence of cortical opacities were linked to having a smaller, not a larger lens [15][16][17]31] . Several studies have shown that diabetics also have an increased risk of developing cortical cataracts and PSCs, although diabetics with well-controlled blood sugar develop a similar spectrum of age-related cataracts as nondiabetics [32,33] .…”