Lenticulostriate vasculopathy in neonates: Is it a marker of cerebral insult? Critical review of the literature

Sisman, J; Rosenfeld, Charles R.

doi:10.1016/j.earlhumdev.2015.04.004

Cited by 15 publications

(15 citation statements)

References 35 publications

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“…The incidence, exact pathophysiology, and significance are still unknown. 28 Fabre et al 29 showed in their retrospective study of 58 neonates with LSV that low-grade LSV (one or two echogenic branches) should be considered as a normal variant. On the other hand, all children with high-grade LSV (at least three echogenic branches) should have close neurological follow-up.…”

Section: Discussionmentioning

confidence: 99%

Infantile Basal Ganglia Stroke after Mild Head Trauma Associated with Mineralizing Angiopathy of Lenticulostriate Arteries: An Under Recognized Entity

et al. 2018

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Basal ganglia infarction in young children, mostly after mild head trauma, has been repeatedly reported. The pathogenesis and the risk factors are not fully understood. Lenticulostriate vasculopathy, usually referred to as basal ganglia calcification, is discussed as one of them. We describe five young (7-13 months old on presentation) male children who suffered from hemiparesis due to ischemic stroke of the basal ganglia, four of them after minor head trauma. All of them had calcification in the basal ganglia visible on computed tomography or cranial ultrasound but not on magnetic resonance imaging. Follow-up care was remarkable for recurrent infarction in three patients. One patient had a second symptomatic stroke on the contralateral side, and two patients showed new asymptomatic infarctions in the contralateral basal ganglia on imaging. In view of the scant literature, this clinic-radiologic entity seems under recognized. We review the published cases and hypothesize that male sex and iron deficiency anemia are risk factors for basal ganglia stroke after minor trauma in the context of basal ganglia calcification in infants. We suggest to perform appropriate targeted neuroimaging in case of infantile basal ganglia stroke, and to consider prophylactic medical treatment, although its value in this context is not proven.

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Section: Discussionmentioning

confidence: 99%

Infantile Basal Ganglia Stroke after Mild Head Trauma Associated with Mineralizing Angiopathy of Lenticulostriate Arteries: An Under Recognized Entity

et al. 2018

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“…The precise incidence and long-term clinical significance of LSV are unclear, and therefore, clinicians have little information with which to counsel parents of infants who have this ultrasound finding. 3 Furthermore, one prior study has demonstrated that there is poor interrater agreement in the identification of LSV by radiologists, leading to even more uncertainty about the significance of this finding. 2 Clinical pathologic correlation has demonstrated that LSV represents thickening of the lenticulostriate arteries supplying the basal ganglia and thalamus, making this typically invisible vasculature apparent on ultrasound.…”

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confidence: 99%

Lenticulostriate Vasculopathy and Neurodevelopmental Outcomes in Preterm Infants: A Systematic Review

et al. 2017

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The objective of this study was to perform a systematic review of all studies that report neurodevelopmental outcomes at 12 months' corrected age or later for preterm infants (< 32 weeks) who are diagnosed with lenticulostriate vasculopathy (LSV) on cranial ultrasound. This is a systematic review. We identified 501 unique publications of which 3 met all prespecified eligibility criteria. Neurodevelopmental outcome data were available for 44 preterm infants with LSV. There were mixed results from the studies: the first reported impairments of mental development; the second reported impairments of motor development only; and finally, the third reported that three of three preterm infants with LSV had mild or moderate developmental delay. The available results raise some concern for future impairments in preterm infants with LSV, but they are conflicting and inconclusive. There is insufficient evidence about the neurodevelopmental implications of LSV in preterm infants to inform counseling of parents.

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“…The reported incidence of LSV ranges from 0.3% to 32%, depending on the population studied. [2][3][4] Because of the technological advances in cerebral ultrasound imaging and growing awareness among doctors of this cerebral ultrasound finding, the incidence of LSV identification has increased since the finding was first recognized. 2,5 The frequencies of transducers used for neonatal cerebral ultrasound 3 decades ago were 5-7.5 MHz, whereas the frequencies of contemporary neonatal cerebral ultrasound transducers range from 10 to 15 MHz, which greatly amplifies echogenicities within the cerebral tissue.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Because of the technological advances in cerebral ultrasound imaging and growing awareness among doctors of this cerebral ultrasound finding, the incidence of LSV identification has increased since the finding was first recognized. 2,5 The frequencies of transducers used for neonatal cerebral ultrasound 3 decades ago were 5-7.5 MHz, whereas the frequencies of contemporary neonatal cerebral ultrasound transducers range from 10 to 15 MHz, which greatly amplifies echogenicities within the cerebral tissue. 6 Although LSV is not a rare finding on cranial ultrasound examination, and despite cranial ultrasound examinations having become a routine examination for neonates admitted to intensive care units, the clinical meaning of LSV remains unclear, and much remains to be understood.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Significance of Lenticulostriate Vasculopathy

2016

ARC Journal of Pediatrics

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Lenticulostriate vasculopathy in neonates: Is it a marker of cerebral insult? Critical review of the literature

Cited by 15 publications

References 35 publications

Infantile Basal Ganglia Stroke after Mild Head Trauma Associated with Mineralizing Angiopathy of Lenticulostriate Arteries: An Under Recognized Entity

Infantile Basal Ganglia Stroke after Mild Head Trauma Associated with Mineralizing Angiopathy of Lenticulostriate Arteries: An Under Recognized Entity

Lenticulostriate Vasculopathy and Neurodevelopmental Outcomes in Preterm Infants: A Systematic Review

Clinical Significance of Lenticulostriate Vasculopathy

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