Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

Abstract

Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.

Diabetic Uterine Environment Leads to Disorders in Metabolism of Offspring

“…On the other hand, the adverse uterine environment of maternal diabetes could cause an increase in placenta weight and elevated glucose levels in both plasma and amniotic fluid ( Laurino et al, 2019 ). In the diabetes, higher placental weights showed reduced placental efficiency and inability to transfer nutrients to the developing fetus ( Volpato et al, 2015 ).…”

Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

“…It was possible to identify that some of these natural products are closely related to the attenuation of inflammatory processes and oxidative stress, such as Picralima nitida , Nauclea latifolia, and Oxytenanthera abyssinica [ 184 ], besides the nano-resveratro-zinc oxide complex, encapsulated with chitosan [ 185 ], raw propolis of stingless bee ( Heterotrigona itama ) [ 186 ], and thymoquinone [ 187 ], while others were related only to antiglycidic and antiinsulinemic activity, such as Hibiscus rosa-sinensis [ 188 ], Orthosiphon stamineus [ 189 ], Lentinus edodes [ 190 ], and Mentha piperita [ 191 ].…”

[Id 56084] Efeitos Dos Cogumelos Agaricus Blazei E Ganoderma Lucidum Sobre O Desenvolvimento Embrionário E Gestacional De Ratas Wistar

“…Conforme demonstra a Tabela 1, no grupo (Ab 1-8 ) observou-se um aumento de fetos nascidos vivos. No trabalho de Laurino et al 24 , as ratas Wistar prenhas, expostas ao pó liofilizado do cogumelo Lentinus edodes (100 mg/kg/dia), antes e após a implantação fetal não foram observadas alterações no número de fetos vivos por mãe entre os grupos estudados e o controle negativo, divergindo ao resultado encontrado nesta pesquisa.…”