Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

Yang, Di; Jia, Wanwan; Zhu, Yi‐Zhun

doi:10.1177/1934578x1601101130

Cited by 9 publications

(7 citation statements)

References 58 publications

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“…Leonurine (YMJ), as an active ingredient, was first extracted as a TCM from Leonurus heterophyllus ( 18 ). YMJ promotes uterine contraction, and prevents osteoporosis, mastitis and myocardial fibrosis ( 19 ). The above functions of YMJ maybe associated with its anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

et al. 2021

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colon. The aim of the present study was to explore the effects of leonurine (YMJ) on inflammation and intestinal microflora in colonic tissues of a dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mouse model. Mice were randomly divided into control (n=5), DSS (n=5, treated with DSS) and DSS+YMJ (n=5, treated with DSS and YMJ) groups. Body weight was recorded, disease activity index (DAI) was calculated, and colon histopathology was evaluated using hematoxylin and eosin staining. Serum interleukin (IL)-6, tumor necrosis factor-α (TNF-α) and IL-1β levels were examined using ELISA. Expression levels of nuclear factor-κB (p65) and phosphorylated (p)-p65 were evaluated via western blotting. 16S ribosomal RNA was extracted from mouse feces. Composition or abundance changes of intestinal microflora were analyzed. The results indicated that YMJ treatment (DSS+YMJ group) significantly increased body weight, reduced DAI scores and increased colon length in UC mouse models compared with those in the DSS group (P<0.05). YMJ significantly reduced inflammatory infiltration, significantly decreased serum TNF-α, IL-6 and IL-1β levels (P<0.05) and significantly downregulated the p-p65/p65 ratio compared with the DSS group (P<0.05). YMJ increased the quantity of the intestinal flora and improved intestinal microflora diversity in the mice of the DSS group. Specifically, YMJ partly regulated intestinal microflora in feces, including a reduction of Bifidobacterium , and an increase in Parasutterella and Ackermania . In conclusion, YMJ improved disease outcomes of the UC mice, reduced the levels of serum inflammatory factors and increased the ratio of beneficial bacteria in the intestinal tract.

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Section: Introductionmentioning

confidence: 99%

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

et al. 2021

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“…Leonurine (C 14 H 21 N 3 O 5, 4-hydroxy-3, 5-dimethoxy, 4-[aminoiminomethyl) amino] butyl ester, the chemical structure shown in Fig. 1A), also known as benzoic acid, is an active alkaloid from food and a traditional Chinese medicine named Herba leonuri [13,14]. Modern pharmacological studies have reported that leonurine has a wide range of biological and pharmacological activities such as antioxidative, anti-inflammatory, antiapoptotic, anti-diabetic, and improving the circulatory system effects [15,16].…”

Section: Introductionmentioning

confidence: 99%

Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway

Chen

Zhou

2019

Aging

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Aging is a complex physiological phenomenon associated with oxidative stress damage. The objective of this study was to investigate the potential effects of leonurine on D-galactose-induced aging in mice and its possible mechanisms. In this study, we first tested the antioxidant activity of leonurine in vitro. A subcutaneous injection of D-galactose in mice for 8 weeks was used to establish the aging model to evaluate the protective effects of leonurine. The results showed that treatment with 150 mg·kg-1 leonurine could improve the mental condition, organic index, and behavioural impairment; significantly increase the activities of antioxidative enzymes including SOD, CAT, and T-AOC; and ameliorate the advanced glycation end product (AGE) level and histopathological injury. Furthermore, the Western blotting data revealed that leonurine supplementation noticeably modulated the suppression of the Nrf2 pathway and upregulated the downstream expression of HO-1 and NOQ1 in aging mice. Additionally, leonurine treatment activated Nrf2 nuclear translocation in both aging mice and normal young mice, and the expression levels of Nrf2 in normal young mice was higher than those in naturally aging mice. In conclusion, our findings suggest that leonurine is a promising agent for attenuating the aging process, and the underlying molecular mechanisms depend on activating the Nrf2 pathway.

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“…Leonurine (4-guanidino-n-butyl syringate, Figure 1 B) extracted from Chinese motherwort Herba leonuri is a natural alkaloid with immense traditional medicinal benefits, including treatment of gynecological, cardiovascular, nervous, cancer, uterine, and skin diseases [ 111 , 112 , 113 ]. The leaf shoot of H. leonuri reduces itching and was used to treat contagious skin diseases such as active shingles in ancient people [ 114 ].…”

Section: Natural Biomolecules Targeting Jak/stat/socs Signaling In Ad...mentioning

confidence: 99%

Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis

2022

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Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by the dysregulation of cytokines and other immune mediators. JAK/STAT is a classical signal transduction pathway involved in various biological processes, and its dysregulation contributes to the key aspects of AD pathogenesis. Suppressor of cytokine signaling (SOCS) proteins negatively regulate the immune-related inflammatory responses mediated by the JAK/STAT pathway. JAK/STAT-mediated production of cytokines including IL-4, IL-13, IL-31, and TSLP inhibits the expression of important skin barrier proteins and triggers pruritus in AD. The expression of SOCS proteins regulates the JAK-mediated cytokines and facilitates maintaining the skin barrier disruptions seen in AD. STATs are crucial in dendritic-cell-activated Th2 cell differentiation in the skin, releasing inflammatory cytokines, indicating that AD is a Th2-mediated skin disorder. SOCS proteins aid in balancing Th1/Th2 cells and, moreover, regulate the onset and maintenance of Th2-mediated allergic responses by reducing the Th2 cell activation and differentiation. SOCS proteins play a pivotal role in inflammatory cytokine-signaling events that act via the JAK/STAT pathway. Therapies relying on natural products and derived biomolecules have proven beneficial in AD when compared with the synthetic regimen. In this review, we focused on the available literature on the potential natural-product-derived biomolecules targeting JAK/STAT/SOCS signaling, mainly emphasizing the SOCS family of proteins (SOCS1, SOCS3, and SOCS5) acting as negative regulators in modulating JAK/STAT-mediated responses in AD pathogenesis and other inflammatory disorders.

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Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

Cited by 9 publications

References 58 publications

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway

Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis

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