Leonurine inhibits breast cancer cell growth and angiogenesis via PI3K/AKT/mTOR pathway

Tian, Junjun; Peng, Lizhong; Wang, Dongjie

doi:10.4314/tjpr.v22i3.7

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Leonurine alkaloid, the primary active biological alkaloid contained within Motherwort, has been acknowledged for its extensive array of biological functions and its exceptional antitumor properties Leorita et al, 2020;Liu et al, 2021;Liang et al, 2022). The cornerstone of Leo's antitumor actions primarily hinge upon its anti-inflammatory and antioxidant activities Tian et al, 2023). Additionally, Leonurine exhibits capacity to impede tumor cell cycles, induce apoptosis in tumor cells, and stimulate the immune system.…”

Section: Abstract Leonurine Anti-tumor Mechanisms Signal Transduction...mentioning

confidence: 99%

New Mechanisms for Anti-Cancer Drugs

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Abstract Leonurine Anti-tumor Mechanisms Signal Transduction...mentioning

confidence: 99%

New Mechanisms for Anti-Cancer Drugs

2024

Frontiers Research Topics

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“…The results of the CCK8 assay, colony formation assay, and colony formation assay showed that LEO significantly inhibited MDA-MB-231 or SK-BR-3 cell proliferation at 400–800 μM concentrations. Moreover, in this dose range, LEO dose-dependently inhibited cell migration, invasion, and angiogenesis ( Tian et al, 2023 ). High-risk human papillomavirus persistent infection and genetic factors are the principal causes of cervical cancer ( Revathidevi et al, 2021 ).…”

Section: Pharmacodynamics Of Leomentioning

confidence: 99%

Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology

Liu,

Sun,

Tang

et al. 2024

Front. Pharmacol.

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Leonurine is an alkaloid unique to the Leonurus genus, which has many biological activities, such as uterine contraction, anti-inflammation, anti-oxidation, regulation of cell apoptosis, anti-tumor, angiogenesis, anti-platelet aggregation, and inhibition of vasoconstriction. This paper summarizes the extraction methods, synthetic pathways, biosynthetic mechanisms, pharmacokinetic properties, pharmacological effects in various diseases, toxicology, and clinical trials of leonurine. To facilitate a successful transition into clinical application, intensified efforts are required in several key areas: structural modifications of leonurine to optimize its properties, comprehensive pharmacokinetic assessments to understand its behavior within the body, thorough mechanistic studies to elucidate how it works at the molecular level, rigorous safety evaluations and toxicological investigations to ensure patient wellbeing, and meticulously conducted clinical trials to validate its efficacy and safety profile.

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“…Leonurine alkaloid, the primary active biological alkaloid contained within Motherwort, has been acknowledged for its extensive array of biological functions and its exceptional antitumor properties ( Zhu et al, 2018 ; Leorita et al, 2020 ; Liu et al, 2021 ; Liang et al, 2022 ). The cornerstone of Leo’s antitumor actions primarily hinge upon its anti-inflammatory and antioxidant activities ( Lin et al, 2020 ; Chen et al, 2023 ; Tian et al, 2023 ). Additionally, Leonurine exhibits capacity to impede tumor cell cycles, induce apoptosis in tumor cells, and stimulate the immune system.…”

Section: Introductionmentioning

confidence: 99%

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Cao,

Wang,

et al. 2023

Front. Pharmacol.

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Leonurine refers to the desiccated aerial portion of a plant in the Labiatae family. The primary bioactive constituent of Leonurine is an alkaloid, Leonurine alkaloid (Leo), renowned for its substantial therapeutic efficacy in the treatment of gynecological disorders, in addition to its broad-spectrum antineoplastic capabilities. Over recent years, the pharmacodynamic mechanisms of Leo have garnered escalating scholarly interest. Leo exhibits its anticancer potential by means of an array of mechanisms, encompassing the inhibition of neoplastic cell proliferation, induction of both apoptosis and autophagy, and the containment of oncogenic cell invasion and migration. The key signal transduction pathways implicated in these processes include the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), the Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), the Signal Transducer and Activator of Transcription 3 (STAT3), and the Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase (MAP/ERK). This paper commences with an exploration of the principal oncogenic cellular behaviors influenced by Leo and the associated signal transduction pathways, thereby scrutinizing the mechanisms of Leo in the antineoplastic sequence of events. The intention is to offer theoretical reinforcement for the elucidation of more profound mechanisms underpinning Leo’s anticancer potential and correlating pharmaceutical development.

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Leonurine inhibits breast cancer cell growth and angiogenesis via PI3K/AKT/mTOR pathway

Cited by 4 publications

References 7 publications

New Mechanisms for Anti-Cancer Drugs

New Mechanisms for Anti-Cancer Drugs

Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

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