Leprosy – An imported disease

Kwan, Zhenli; Pailoor, Jayalakshmi; Tan, Leng Leng; Robinson, Suganthy; Wong, Su‐Ming; Ismail, Razidah

doi:10.47276/lr.85.3.170

Cited by 6 publications

(1 citation statement)

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“…It may not be easily recognized because of its rarity in non-endemic countries, as well as its similarity with some other manifestations of rheumatic disease and other causes of vasculitis [ 4 ]. In a study conducted in Malaysia involving 27 cases between 2008–2013, Kwan et al [ 9 ] reported that up to 44% of cases seen initially in a primary care setup were misdiagnosed. Our patient was treated as having a fungal infection that was superimposed with a bacterial infection on day 3 of illness by the local primary care doctor despite having common signs of madarosis, thickened earlobes, and sloughing of the fingernails.…”

Section: Discussionmentioning

confidence: 99%

Lucio Phenomenon: Sequelae of Neglected Leprosy

Muhamad

Zakaria

et al. 2021

Korean J Fam Med

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Lucio phenomenon is a potentially fatal leprosy reaction seen in pure, primitive, and diffuse form of lepromatous leprosy. It is a globally restricted phenomenon that occurs in Mexico and Costa Rica; however, sporadic cases have been reported elsewhere. We report a rare case of a 50-year-old Indonesian, who resided in Malaysia for the past 33 years, which presented with extensive ulcers on all four limbs for 3 weeks, as well as a 16-year history of skin changes and alopecia. Full evaluation established the diagnosis of lepromatous leprosy with Lucio phenomenon. Delay in diagnosis leads to significant disabilities and disease transmission within the community. Therefore, primary care practitioners, even in non-endemic countries, should be wary of this atypical feature of leprosy to prevent complications since it is a highly curable disease.

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Section: Discussionmentioning

confidence: 99%

Lucio Phenomenon: Sequelae of Neglected Leprosy

Muhamad

Zakaria

et al. 2021

Korean J Fam Med

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Imported and autochthonous leprosy presenting in Madrid (1989–2015): A case series and review of the literature

Norman

Fanciulli

Pérez-Molina

et al. 2016

Travel Medicine and Infectious Disease

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Leprae reaction resembling rheumatologic disease as presenting feature of leprosy

et al. 2016

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Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae with predominant involvement of skin and nerves. We present a 70-year-old man with leprosy whose initial presentation resembled rheumatologic disease, due to leprae reaction. He presented with an 8-week history of worsening neuropathic pain in the right forearm, associated with necrotic skin lesions on his fingers that had ulcerated. Physical examination revealed two tender necrotic ulcers at the tip of the right middle finger and the dorsal aspect of the left middle finger. The patient had right wrist tenosynovitis and right elbow bursitis. Apart from raised inflammatory markers, the investigations for infection, connective tissue disease, vasculitis, thromboembolic disease and malignancy were negative. During the fourth week of hospitalization, we noticed a 2-cm hypoesthetic indurated plaque on the right inner arm. Further examination revealed thickened bilateral ulnar, radial and popliteal nerves. A slit skin smear was negative. Two skin biopsies and a biopsy of the olecranon bursa revealed granulomatous inflammation. He was diagnosed with paucibacillary leprosy with neuritis. He responded well to multidrug therapy and prednisolone; his symptoms resolved over a few weeks. This case illustrates the challenges in diagnosing a case of leprosy with atypical presentation in a non-endemic country.

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Leprosy – An imported disease

Cited by 6 publications

References 0 publications

Lucio Phenomenon: Sequelae of Neglected Leprosy

Lucio Phenomenon: Sequelae of Neglected Leprosy

Imported and autochthonous leprosy presenting in Madrid (1989–2015): A case series and review of the literature

Leprae reaction resembling rheumatologic disease as presenting feature of leprosy

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