Leptin: A Correlated Peptide to Papillary Thyroid Carcinoma?

Hedayati, Mehdi; Yaghmaei, Parichehreh; Pooyamanesh, Zahra; Yeganeh, Marjan Zarif; Rad, Laleh Hoghooghi

doi:10.4061/2011/832163

Cited by 30 publications

(21 citation statements)

References 39 publications

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“…The comparison between patients and controls revealed higher levels of leptin and ICAM‐1 in patients. Our findings are consistent with those of previous studies, which demonstrated significantly higher levels of leptin in patients with thyroid cancer relative to a control group and a significant drop in serum leptin levels after surgical resection of thyroid cancer 21, 22. It is interesting to note that high leptin levels reportedly portend an aggressive disease course in breast and prostate cancer,23‐27 and an altered leptin signaling network, in concert with the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt) signaling pathway, reportedly plays a role in thyroid cancer development 28, 29.…”

Section: Discussionsupporting

confidence: 93%

Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer

Owonikoko

Hossain

Bhimani

et al. 2013

Cancer

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Background Reliable predictive biomarkers are required to address the challenge of disease recurrence following thyroid cancer surgery. We assessed the association of cellular- and serum-based immunologic mediators with thyroid cancer recurrence. Methods Leukocyte subset counts and immune regulatory cytokines were determined in peripheral blood samples using multiparameter flow cytometry and 51-panel multiplex ELISA (Luminex) assays, respectively. Functional activity of circulating B-, T- and NK lymphocytes was assessed ex vivo. Differences in mean biomarker levels between defined subject groups and correlations between biomarkers and cancer recurrence were assessed by t-test or Wilcoxon test and by univariate and multivariate analyses with Cox model. Optimal cut-off values of significantly correlated biomarkers that best predict recurrence post surgery were established by receiver operating characteristics and validated by the optimal cut-point determination algorithm. Results We enrolled 35 patients (median age - 49.4 years; 24 females; 15 patients with disease recurrence) and 21 controls. Patients without recurrence had higher levels of soluble FAS ligand (sFASL), TGF-b, T-regs and PD-1/PD-L1 expressing leukocytes. sFASL (HR:0.60; 95%CI:0.38–0.95; p=0.031) and IFN-α (HR:1.55; 95%CI:1.03–2.34; p=0.038) showed significant association with cancer recurrence. There was a significant difference in PFS between patient groups stratified by sFASL optimal cut-point of 15 pg/ml (Logrank p=0.0009). Conclusions sFASL and IFN-α showed significant correlation with thyroid cancer recurrenceand may be useful for risk-adapted surveillance strategies for thyroid cancer.

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Section: Discussionsupporting

confidence: 93%

Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer

Owonikoko

Hossain

Bhimani

et al. 2013

Cancer

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“…Furthermore, leptin levels decreased in patients 20 days after total thyroidectomy although remained significantly higher than the control group . Similarly, in an Iranian cross‐sectional study (BEL 3, GR C) of patients with PTC ( n = 83) vs. controls ( n = 90), serum leptin levels were higher in the former . Lack of adjustment for potential confounders and the relatively small number of subjects in these studies casts doubt about the reliability and/or generalizability of their results, which need to be confirmed or refuted by future studies.…”

Section: Obesity and Thyroid Cancer Risk: Potential Mediatorsmentioning

confidence: 92%

Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms

2013

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The incidence of thyroid cancer has been rising over the past few decades along with a parallel increase in obesity. Observational studies have provided evidence for a potential association between the two. By contrast, clinical data for a link between type 2 diabetes mellitus, a condition strongly associated with obesity, and thyroid cancer are limited and largely not supportive of such an association. Obesity leads to hypoadiponectinemia, a pro-inflammatory state, and insulin resistance, which, in turn, leads to high circulating insulin and insulin-like growth factor-1 levels, thereby possibly increasing the risk for thyroid cancer. Thus, insulin resistance possibly plays a pivotal role in underlying the observed association between obesity and thyroid cancer, potentially leading to the development and/or progression of thyroid cancer, through its interconnections with other factors including insulin-like growth factor-1, adipocytokines/cytokines and thyroid-stimulating hormone. In this review, epidemiological and clinical evidence and potential mechanisms underlying the proposed association between obesity and thyroid cancer risk are reviewed. If the association between obesity and thyroid cancer demonstrated in observational studies proves to be causal, targeting obesity (and/or downstream mediators of risk) could be of importance in the prevention and management of thyroid cancer.

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“…Some studies have described the presence of high leptin levels in patients with DTC (24). Cheng and cols.…”

Section: Case Reportmentioning

confidence: 99%

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy

Lima¹,

Fernandes²,

Montenegro³

et al. 2019

Archives of Endocrinology and Metabolism

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Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Here, we reported a rare case of a type 2 CGL in a girl who presented with a papillary TC (PTC) at the age of 7 years. She had no family history of TC or previous exposure to ionizing radiation. She had a generalized lack of subcutaneous fat, including the palmar and plantar regions, muscle hypertrophy, intense acanthosis nigricans, hepatomegaly, hypertriglyceridemia, severe insulin resistance, and hypoleptinemia. A genetic analysis revealed a mutation in the BSCL2 gene (p.Thr109Asnfs* 5). Ultrasound revealed a hypoechoic solid nodule measuring 1.8 × 1.0 × 1.0 cm, and fine needle aspiration biopsy suggested malignancy. Total thyroidectomy was performed, and a histopathological examination confirmed PTC with vascular invasion and parathyroid lymph node metastasis (pT3N1Mx stage). This is the first report to describe a case of differentiated TC in a child with CGL. Severe insulin resistance that is generally observed in patients with CGL early in life, especially in those with type 2 CGL, may be associated with this uncommon presentation of aggressive PTC during childhood. Arch Endocrinol Metab. 2019;63(1):79-83

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Leptin: A Correlated Peptide to Papillary Thyroid Carcinoma?

Cited by 30 publications

References 39 publications

Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer

Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer

Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy

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