Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2 lipodystrophic mice independent of hepatocyte leptin receptors

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

“…In a previous study, as in ours, serum levels of resistin positively correlated with bilirubin [68]. Our data are also in line with recent experiments showing that the majority of metabolic effects of leptin essential for energy homeostasis are dependent on its action in nonhepatocyte cells and/or the central nervous system [70].…”

Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish

“…Thus, our results above reveal that the depletion of socs1a causes a complex metabolic syndrome, including local hypoxia stress, progressive hepatic steatosis, and insulin resistance in fish. Based on the observed loss of visceral and subcutaneous fat, hepatic steatosis, and hepatic insulin resistance, our socs1a-deficient zebrafish display a phenotype similar to that observed in mammalian models with lipodystrophy (6). Our data provide strong evidence that SOCS1a acts as an essential negative regulator of GH signaling mediated by JAK-STAT5 in zebrafish.…”

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

“…154 This contention is supported by the observation that selective deletion of leptin receptors in hepatocytes did not prevent the positive metabolic actions of leptin in Agpat2 -/-mice. 155 Metreleptin therapy can ameliorate macroalbuminuria, microalbuminuria and hyperfiltra tion. 48,152 An improvement in sex hormone profile with leptin therapy has been observed with metreleptin, which is likely to occur both from increasing insulin sensitivity and from restoring luteinizing hormone pul satility.…”