Leptin and the Regulation of the Hypothalamic–Pituitary–Adrenal Axis

Malendowicz, Ludwik K.; Ruciński, Marcin; Belloni, Anna S.; Ziółkowska, Agnieszka; Nussdorfer, Gastone G.

doi:10.1016/s0074-7696(07)63002-2

Cited by 99 publications

(59 citation statements)

References 210 publications

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“…Because leptin plays a known regulatory role in the HPA axis (Malendowicz et al 2007), leptin levels were measured and compared between genotypes. As expected and consistent with increases in body weight and metabolic indices, leptin levels increased significantly with HF feeding among both genotypes (Fig.…”

Section: Resultsmentioning

confidence: 99%

The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic–pituitary–adrenal axis hyperactivity

Evans

Islam²,

Urade³

et al. 2012

Journal of Endocrinology

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Obesity and diabetes are closely associated with hyperactivation of the hypothalamicpituitary-adrenal (HPA) axis. In this study, the diet-induced obese C57BL/6 mouse was used to test the hypothesis that chronically elevated metabolic parameters associated with the development of obesity such as cholesterol and glucose can aggravate basal HPA axis activity. Because the lipocalin-type prostaglandin D 2 synthase (L-PGDS) knockout (KO) mouse is a model of accelerated insulin resistance, glucose intolerance, and obesity, it was further hypothesized that HPA activity would be greater in this model. Starting at 8 weeks of age, the L-PGDS KO and C57BL/6 mice were maintained on a low-fat or high-fat diet. After 20 or 37 weeks, fasting metabolic parameters and basal HPA axis hormones were measured and compared between genotypes. Correlation analyses were performed to identify associations between obesity-related chronic metabolic changes and changes in the basal activity of the HPA axis. Our results have identified strong positive correlations between total cholesterol, LDL-cholesterol, glucose, and HPA axis hormones that increase with age in the C57BL/6 mice. These data confirm that obesity-related elevations in cholesterol and glucose can heighten basal HPA activity. Additionally, the L-PGDS KO mice show early elevations in HPA activity with no age-related changes relative to the C57BL/6 mice.

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Section: Resultsmentioning

confidence: 99%

The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic–pituitary–adrenal axis hyperactivity

Evans

Islam²,

Urade³

et al. 2012

Journal of Endocrinology

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“…Furthermore, the retroperitoneal white adipose tissue of MS females did not differ from NH females at 2 months of age (our preliminary data not shown). Many studies have reported that leptin is a stress responding hormone and its action may be related with the HPA axis activity (Heiman et al, 1997;Tasker, 2006;Malendowicz et al, 2007). It is suggested that a decreased plasma leptin level in MS females may implicate their HPA axis dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

et al. 2011

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“…Leptins also were identified in non-mammalians, including birds [3][4][5], reptiles [2], amphibians [6][7][8], and teleosts, the later generally possess duplicated leptins [8][9][10][11][12][13][14][15]. Leptin has been found to be responsible for the regulation of body weight and energy homeostasis [16,17], and it also is involved in regulating appetite, reproduction [18], the immune system [19], bone formation [20], angiogenesis [21], and stress response [22,23].…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, characterization and evolutionary analysis of leptin gene in Chinese giant salamander, Andrias davidianus

Tian

Meng

et al. 2017

Open Life Sciences

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Abstract:Leptin is an important hormone possessing diverse physiological roles in mammals and teleosts. However, it has been characterized only in a few amphibian species, and its evolutions are still under debate. Here, the full length of the leptin (Adlep) cDNA of Chinese giant salamander (Andrias davidianus), an early diverging amphibian species, is characterized and according to the results of the primary sequence analysis, tertiary structure reconstruction and phylogenetic analysis is confirmed to be an ortholog of mammalian leptin. An intron was identified between the coding exons of A. davidianus leptin, which indicated that the leptin is present in the salamander genome and contains a conserved gene structure in vertebrates. Adlep is widely distributed but expression levels vary among different tissues, with highest expression levels in the muscle. Additionally, the leptin receptor and other genes were mapped to three known leptin signaling pathways, suggesting that the leptin signaling pathways are present in A. davidianus. Phylogenetic topology of leptins are consistent with the generally accepted evolutionary relationships of vertebrates, and multiple leptin members found in teleosts seem to be obtained through a Cluopeocephala-specific gene duplication event. Our results will lay a foundation for further investigations into the physiological roles of leptin in A. davidianus.

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Leptin and the Regulation of the Hypothalamic–Pituitary–Adrenal Axis

Cited by 99 publications

References 210 publications

The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic–pituitary–adrenal axis hyperactivity

The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic–pituitary–adrenal axis hyperactivity

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

Molecular cloning, characterization and evolutionary analysis of leptin gene in Chinese giant salamander, Andrias davidianus

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