Leptin, Blood Pressure, and Aerobic Capacity in Women

Sabatier, Manning J.; McCully, Kevin K.; Marinik, Elaina L.; Schwark, Earl H.; Haddow, Sara; Cortez‐Cooper, Miriam; Bergeron, Michael F.; Sloan, Gloria; Cannon, Joseph G.

doi:10.1038/ajh.2008.254

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…However, based on the medical literature, several mechanisms have been proposed to explain the BP-raising effect of leptin, 5,[29][30][31] and in particular the leptin-induced increased activity in the sympathetic nervous system has been in focus as a BP-raising mechanism. We found a significant interaction between hyperleptinemia and level of physical activity, as reported elsewhere, 18 which may explain why physical fit overweight subjects can stay normotensive. Finally, it should be noted that BMI also was an independent predictor of new-onset hypertension, so other factors than leptin are involved in overweight-related hypertension.…”

Section: Perspectivessupporting

confidence: 64%

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Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

Asferg

Møgelvang

Flyvbjerg

et al. 2010

American Journal of Hypertension

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Hypertension is a leading cause of death worldwide. 1 Overweight caused by adipose tissue is a major risk factor for hypertension, 2,3 and indeed overweight and hypertension are disorders that are closely interrelated, but the mechanisms remain elusive. 2,3 During the past decades, it has become clear that adipose tissue is not just an inactive energy-storing organ. 2,3 Quite the opposite, adipose tissue is an endocrine organ that secretes hormones and cytokines with vascular and inflammatory effects, and it has been suggested that these molecules play a pivotal role in overweight-related diseases, including hypertension. [2][3][4] Leptin and adiponectin are two such adipocyte-derived hormones, and both hormones are candidate intermediaries between adipose tissue and overweight-related disorders. [2][3][4][5][6] Interestingly, leptin and adiponectin are oppositely associated with a series of cardiometabolic risk factors. Leptin is positively correlated with body mass index (BMI), waist circumference, triglycerides, markers of inflammation, and glucose, and negatively with insulin sensitivity and high-density lipoprotein cholesterol (HDL-C), 2-7 whereas adiponectin is negatively correlated with BMI, waist circumference, triglycerides, markers of inflammation, and glucose, and positively with insulin sensitivity and HDL-C. 2-7 Because of these relationships, hyperleptinemia and hypoadiponectinemia have been linked with the metabolic syndrome and cardiovascular injury. [2][3][4][5][6] With respect to the role of leptin and adiponectin in the development of hypertension, the situation is less clear. Hyperleptinemia was associated with greater risk of newonset hypertension in one study, 8 but not in another. 9 In two prospective studies, including women and men of Asian origin, hypoadiponectinemia was associated with incident Background Leptin and adiponectin are hormones secreted by adipose tissue, and both hormones are candidate intermediaries between adipose tissue and overweight-related diseases. So far, no prospective study has been published where the independent effects of these two hormones on the development of hypertension have been directly compared. The objective of this study was to investigate the relationships between plasma levels of leptin and adiponectin and new-onset hypertension in the copenhagen city heart Study (cchS).

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Section: Perspectivessupporting

confidence: 64%

“…Finally, possible interactions regarding leptin and adiponectin were investigated, in particular a possible interaction between leptin and level of physical activity, as reported elsewhere. 18 …”

Section: Definition Of New-onset Hypertensionmentioning

confidence: 99%

Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

Asferg

Møgelvang

Flyvbjerg

et al. 2010

American Journal of Hypertension

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“…The high risk of developing cardiovascular diseases in obese subjects has also drawn attention to study the neurohormonal effects of leptin on cardiac functioning and remodeling. A relationship between the circulating leptin level with hypertension and associated cardiovascular morbidity has been reported recently (3,7,8). Kramer et al (9) also observed increased leptin levels among hypertensive elderly subjects and reported that higher leptin level increases 70% chances of risks for subsequent hypertension.…”

Section: Introductionmentioning

confidence: 83%

“…Recently, Patel et al (7) also reported positive association between leptin and DBP. The relationship between leptin and hypertension was also studied by Sabatier et al (8), and their results illustrated that leptin-mediated actions may be diminished not only by reducing leptinproducing adipose tissue, but also by increasing physical activity in individuals with high levels of adiposity. Another recent study (9) has reported increased leptin levels among hypertensive elderly subjects.…”

Section: Discussionmentioning

confidence: 99%

Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women

Khokhar

Sidhu²,

Kaur³

2010

European Journal of Endocrinology

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Objective: The present study was aimed at evaluating the correlation between leptin and hypertension in normal and obese hypertensive pre-(Pre-M) and postmenopausal (Post-M) women of Jalandhar city (Punjab, India). Design: For the present study, 78 Pre-M and Post-M women were recruited in four categories as follows: i) normal normotensive, ii) obese normotensive, iii) normal hypertensive, and iv) obese hypertensive. Body mass index was considered as the index of obesity. Guidelines given by JNC-VII were followed for the assessment of hypertension. Leptin was assayed by sandwich ELISA, and estradiol (E 2 ) was assayed by competitive ELISA. Results: Leptin level was found to be significantly higher in normal Pre-M women (P!0.02) than that of normal Post-M women. Obese subjects had significantly higher leptin level (P!0.001) than the normal women. In the case of hypertensive subjects, leptin level was significantly higher than that of normotensive counterparts. E 2 level was found significantly lower in Post-M women (P!0.001) than that of Pre-M women as well as in hypertensive women than that of normotensive subjects. A positive correlation was observed between blood pressure (BP) and leptin, but significant association was observed in hypertensive normal and obese Pre-M and Post-M women only. Conclusion: It is concluded from the present findings that leptin contributes to the regulation of BP in hypertensive normal as well as in the obese Pre-M and Post-M women. So, leptin may be a regulator of BP in hypertensive women independent of the degree of obesity and the menopausal status.

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“…The relationship between leptin concentrations and aerobic PF was previously presented by Kiviniemi et al [22] but was not observed by others [23,41]. Sabatier et al [40] studied women and found however that the cardiovascular consequence of leptin and fatness through increased arterial pressure can be diminished by the level of PF.…”

Section: Discussionmentioning

confidence: 80%

Physical Fitness Is Independently Related to Blood Leptin Concentration and Insulin Sensitivity Index in Male Subjects with Central Adiposity

Saafi¹,

Frere-Meunier

Féasson³

et al. 2012

Obes Facts

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Aim: To compare the maximal power output (MPO) of subjects presenting a central adiposity to those of controls and to study the links between plasma leptin or indices of insulin sensitivity (QUICKI) and physical fitness (PF). Methods: MPO was determined for 169 middle-aged men divided into two groups according to waist circumference (WC– < 94 cm, WC+ ≧ 94 cm) each subdivided in two subgroups with low and high PF (WC-L, WC-H, WC+L, WC+H) determined from the median MPO relative to fat free mass (3.06 W/kg_FFM). Results: MPO (W/kg_FFM) was lower in WC+ than in WC–. Expressed relative to fat mass, leptin was lower and QUICKI higher in WC– than in WC+. In WC+H, leptin and QUICKI were significantly less disturbed than in WC+L and were independently correlated to MPO (r = –0.36 and r = 0.32 respectively; p < 0.001). In WC+, when visceral perimeter was added to the analysis, the relationships MPO/leptin remained significant but not MPO/QUICKI. Conclusion: The low PF in subjects with abdominal obesity is independently linked to plasma leptin and insulin sensitivity even if leptin and insulin may share common pathways in their peripheral effects. Visceral adiposity participates to the link between MPO and QUICKI, but not between MPO and leptin.

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Leptin, Blood Pressure, and Aerobic Capacity in Women

Abstract: Circulating leptin concentrations are related to body fatness, but the hypertensive influence of leptin is modified by physical fitness.

Cited by 11 publications

References 30 publications

Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women

Physical Fitness Is Independently Related to Blood Leptin Concentration and Insulin Sensitivity Index in Male Subjects with Central Adiposity

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