Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents

Reinehr, Thomas; Woelfle, Joachim; Wiegand, Susanna; Karges, Beate; Meißner, Thomas; Nagl, Katrin; Holl, Reinhard W.

doi:10.1111/pedi.12276

“…Adolescents with T2DM were recruited from the DPV dataset (for details of this cohort see (2,25)). Briefly, T2DM was diagnosed based on the criteria of the American Diabetes Association identical to German guidelines (26).…”

Section: Subjectsmentioning

confidence: 99%

“…Numerous adipose tissue-derived hormones have been shown to predict T2DM and to be involved in the pathogenesis of T2DM. For example, we have recently reported that leptin levels but not adiponectin levels differ between obese adolescents with and without T2DM (2). Moreover, recent data revealed increasing evidence that also liver-derived hormones might affect glucose metabolism.…”

mentioning

confidence: 98%

Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes

Reinehr¹,

Karges

²

,

Meißner

³

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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“…However, this would be rather an indirect/downstream effect on serum leptin levels than an effect of polymorphisms directly acting on LEP gene transcription and protein expression, and the hypothesis is not yet proven. In contrast, in a recent but small study, leptin levels were shown to be significantly lower in an adolescent group with T2D compared to a BMI-, age-, and gender-matched control group without T2D (74 in each group), with equal adiponectin levels in both groups [62].…”

Section: Leptin (Lep)mentioning

confidence: 61%

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Schleinitz

¹

2015

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■ AbstractAdipose tissue secretes an abundance of proteins. Some of these proteins are known as adipokines and adipose-derived hormones which have been linked with metabolic disorders, including type 2 diabetes, and even with cancer. Variance in serum adipokine concentration is often closely associated with an increase (obesity) or decrease (lipodystrophy) in fat tissue mass, and it is affected by age, gender, and localization of the adipose tissue. However, there may be genetic variants which, in consequence, influence the serum concentration of a certain adipokine, and thereby promote metabolic disturbances or, with regard to the "protective" allele, exert beneficial effects. This review focuses on the genetic determination of serum levels of the following adipokines: adiponectin, chemerin, leptin, progranulin, resistin, retinol binding protein 4, vaspin, adipsin, apelin, and omentin. The article reports on the latest findings from genome-wide association studies (GWAS) and candidate gene studies, showing variants located in/nearby the adipokine genes and other (non-receptor) genes. An extra chapter highlights adipokine-receptor variants. Epigenetic studies on adipokines are also addressed.

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“…leptin levels were shown to be significantly lower in an adolescent group with T2D compared to a BMI-, age-, and gender-matched control group without T2D (74 in each group), with equal adiponectin levels in both groups [62].…”

Section: Leptin (Lep)mentioning

confidence: 84%

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Schleinitz¹

2016

Rev Diabet Stud

0

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■ AbstractAdipose tissue secretes an abundance of proteins. Some of these proteins are known as adipokines and adipose-derived hormones which have been linked with metabolic disorders, including type 2 diabetes, and even with cancer. Variance in serum adipokine concentration is often closely associated with an increase (obesity) or decrease (lipodystrophy) in fat tissue mass, and it is affected by age, gender, and localization of the adipose tissue. However, there may be genetic variants which, in consequence, influence the serum concentration of a certain adipokine, and thereby promote metabolic disturbances or, with regard to the "protective" allele, exert beneficial effects. This review focuses on the genetic determination of serum levels of the following adipokines: adiponectin, chemerin, leptin, progranulin, resistin, retinol binding protein 4, vaspin, adipsin, apelin, and omentin. The article reports on the latest findings from genome-wide association studies (GWAS) and candidate gene studies, showing variants located in/nearby the adipokine genes and other (non-receptor) genes. An extra chapter highlights adipokine-receptor variants. Epigenetic studies on adipokines are also addressed.

show abstract

Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents

Cited by 28 publications

References 53 publications

Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes

Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

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