Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone

Messinis, Ioannis E.; Milingos, S; Zikopoulos, Konstantinos; Kollios, G.; Seferiadis, K.; Lolis, D.

doi:10.1093/humrep/13.5.1152

Cited by 79 publications

(49 citation statements)

References 21 publications

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“…Serum leptin levels fluctuate during the menstrual cycle, with significantly higher levels in the luteal phase than in the follicular phase (10,31,32). In the present study, menstrual cycles were not included in the analyses, but the phase of the cycle should be taken into consideration when studying leptin levels postmenarche.…”

Section: Discussionmentioning

confidence: 97%

Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern

Ankarberg‐Lindgren

Dahlgren²,

Carlsson³

et al. 2001

European Journal of Endocrinology

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Objective: To investigate the levels and diurnal rhythm of serum leptin in healthy children, and to investigate the association between leptin levels and sex steroids. Methods: Four girls and four boys, all healthy volunteers, were followed longitudinally throughout puberty. Their chronological ages ranged from 8.7 to 19.5 years, and body composition, expressed as weight-for-height standard deviation scores (SDS), ranged between 21.7 and +2.4. Serum leptin, oestradiol and testosterone concentrations were measured by radioimmunoassay at 1000, 1400, 1800, 2200, 0200 and 0600 h. Results: In all girls and boys, both prepubertally and during pubertal development, serum leptin levels increased during the night, with no difference in relative peak amplitude. In boys, the leptin concentrations increased until the initiation of puberty and then declined, whereas in girls, the concentrations increased throughout puberty. The inter-individual variation in mean leptin levels among girls decreased to 11% at the time of menarche. A positive correlation was found for both oestradiol and testosterone versus leptin in girls throughout puberty r 0X64 and r 0X71 respectively, P , 0X001X A negative correlation was found between leptin and testosterone in boys in mid-and late puberty r 20X66Y P , 0X01X No correlation was found between oestradiol and leptin in boys or between testosterone and leptin in pre-and early pubertal boys. Conclusion: Serum leptin concentrations show diurnal variation throughout pubertal development in both girls and boys. The changes in leptin levels during puberty follow a gender-specific pattern, probably due to an influence of sex steroids on leptin production.

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Section: Discussionmentioning

confidence: 97%

Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern

Ankarberg‐Lindgren

Dahlgren²,

Carlsson³

et al. 2001

European Journal of Endocrinology

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“…The results published to date on leptin levels in the menstrual cycle differ remarkably. Some studies showed significant increase of leptin in the late follicular phase (9, 10), some on the day of the LH surge onset (11,12), while others in the late luteal phase (13)(14)(15)(16)(17). Further studies reported small, non-significant variations during the menstrual cycle (18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17b-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1-2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1-5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.European Journal of Endocrinology 155 137-142

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“…Leptin has negative effects on various growth factors (IGF-1, TGF-beta) and hormones (insulin, glucocorticoids) that affect gonadotropin stimulated sex steroid hormones when utilized over 10 ng/ml (21)(22)(23)(24). In addition, higher doses of leptin decrease ovarian estradiol synthesis and block the dominant follicle development and oocyte maturation.…”

Section: Discussionmentioning

confidence: 99%

The effects of GnRH analogs on serum and follicular fluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology

Ergenoğlu

Yeniel

Akdoğan

et al. 2012

J Turkish German Gynecol Assoc

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Objective:To determine serum and follicular leptin levels in patients using gonadotropin releasing hormone agonist and antagonist in Assisted Reproductive Technology short protocol cycles and to evaluate pregnancy outcomes. Material and Methods:Patients randomly selected to join assisted reproductive technology cycles during February 2004-July 2004 were enrolled in this study. Group 1 consisted of 21 patients receiving r FSH+ GnRH agonists, whereas Group 2 consisted of 34 patients who received r FSH +GnRH antagonists. During the ovulation induction period 5 serum samples were collected (induction day 1, day 3 or antagonist starting day, human chorionic hormone day, oocyte pickup day, and twelfth day of embryo transfer). Follicular fluid samples were collected to be evaluated for leptin, estradiol, prolactin and luteinizing hormone.Results: There was no difference in age, basal FSH, basal LH, and basal E2 between groups. Serum leptin levels were similar in both groups. Also, when each group's serum leptin levels were evaluated according to the presence of pregnancy, there was no significant difference in both groups. When follicle leptin levels were evaluated according to the existence of pregnancy, in both groups the follicle leptin levels were lower in pregnant participants but this difference was not statistically significant. When obesity is defined as body mass index over 26.5, there is a correlation between obesity and leptin levels in Group 2. Conclusion:Our results have shown that both agonists and antagonists have similar efficacy and effect in poor responder women. Leptin levels in either groups, whether pregnant or non-pregnant were not statistically different. This result shows the need for more studies on leptin in infertility. (J Turkish-German Gynecol Assoc 2012; 13: 91-7)Key words: GnRH agonist, GnRH antagonist, ART, leptin, prolactin Received: 10 January, 2012 Accepted: 19 January, 2012 Amaç: Yardımcı Üreme Teknikleri (YÜT) ile kısa protokol uygulanan sikluslarda gonadotropin salgılatıcı hormon (GnRH) agonist ve antagonist uygulanan olgularda serum ve foliküler leptin seviyelerinin belirlenmesi ve gebelik sonuçlarının değerlendirilmesidir. Bulgular: Gruplar arasında yaş, bazal FSH, bazal LH ve bazal E2 açı-sından fark izlenmedi. Serum leptin düzeyleri her iki grupta benzer idi. Ayrıca her grupta gebelik varlığına göre serum leptin seviyeleri değer-lendirildiğinde gruplar arasında fark izlenmedi. Folikül leptin seviyeleri gebelik mevcudiyetine göre değerlendirildiğinde her iki grupta da folikül leptin seviyeleri gebe olgularda daha düşük olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Obesite vücut kitle indeks değerinin 26.5 üzerinde olması olarak tanımlandığında Grup 2'de leptin seviyeleri ile obesite arasında korelasyon mevcut idi. Gereç ve Yöntemler:Sonuç: Sonuçlarımız düşük cevaplı olgularda hem agonistlerin hem de antagonistlerin benzer etkinlik ve etkiye sahip olduğunu göstermiş-tir. Her iki grupta da leptin seviyeleri gebe olanlarda veya olmayanlarda istatistiksel olarak...

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Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone

Cited by 79 publications

References 21 publications

Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern

Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

The effects of GnRH analogs on serum and follicular fluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology

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