Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression

Milaneschi, Yuri; Lamers, Femke; Bot, Mariska; Drent, Madeleine L.; Penninx, Brenda W. J. H.

doi:10.1016/j.biopsych.2015.10.023

Cited by 167 publications

(166 citation statements)

References 41 publications

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“…In agreement with this, overweight, obesity, and metabolic abnormalities, including leptin deregulation, appear to be more prevalent in atypical depression than in melancholic/typical depression (Chou and Yu, 2013;Cizza et al, 2012;Lamers et al, 2010;Lasserre et al, 2014;Levitan et al, 2012;Milaneschi et al, 2015). Interestingly, the association of atypical depression with leptin alterations was found to be stronger for increased adiposity levels (Milaneschi et al, 2015), pointing to a role for adiposity in this relationship. This finding also supports the hypothesis that depression with atypical features represents a metabolic subtype of depression likely related to adiposity (Lamers et al, 2010;Penninx et al, 2013).…”

Section: Fat and Depression: A Vicious Circlesupporting

confidence: 54%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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Section: Fat and Depression: A Vicious Circlesupporting

confidence: 54%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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“…This could have important clinical implications. Depression with increased appetite is associated with systemic metabolic and immune abnormalities [57–59] that likely influence energy homeostasis in profound ways. If the account described here is correct, a down-stream consequence of this physiological dysregulation may be that depression with increased appetite is associated with differences in the conceptual representation of emotion that could either contribute to depression, or serve as a point of intervention during psychotherapy.…”

Section: Interoceptive Hypersensitivity May Predispose Some Individuamentioning

confidence: 99%

Interoceptive contributions to healthy eating and obesity

Simmons

DeVille

2017

Current Opinion in Psychology

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Obesity results from persistent failure by the brain to balance food intake with energy needs, resulting in a state of chronic energy surplus. Although there are many factors that predispose individuals to weight gain and obesity, the current review focuses on two ways eating behavior may be influenced by sensitivity to interoceptive signals of hunger, satiety, and metabolic energy reserves. First, obesity may be related to hypersensitivity to interoceptive signals of hunger, leading to positive alliesthesia for food cues that undermine attempts to change unhealthy eating behaviors. Second, overeating and obesity may arise from an inability to accurately detect interoceptive signals of satiety and positive energy balance. The findings reviewed herein demonstrate that obesity may be related to altered interoception, and warrant the continued development of novel obesity interventions aimed at promoting interoceptive awareness.

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“…While effective treatment of depression has not been definitively linked with recovery of serum adiponectin levels 32 , exogenous administration of adiponectin has been found to have antidepressant-like benefits in animal models 33 . Leptin, a negative feedback regulator of fat tissue, is reliably reduced in chronic stress levels 32 , although any association with depression may be complexly moderated by other factors such as body weight, metabolic function 34 , and depression subtype 35 . To date, other adipokines such as chemerin or vaspin have not been studied for potential associations with depression.…”

Section: Depression and Inflammation In The General Populationmentioning

confidence: 99%

Roles of Inflammation and Depression in the Development of Gestational Diabetes

Robakis

Aasly

Williams

et al. 2017

Curr Behav Neurosci Rep

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Inflammation, the body’s response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.

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Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression

Cited by 167 publications

References 41 publications

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Interoceptive contributions to healthy eating and obesity

Roles of Inflammation and Depression in the Development of Gestational Diabetes

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