Leptin expression in proliferative, secretory and hyperplastic endometrial tissues

Özler, Ali; Kuşçu, Naci Kemal; Temız, Peyker; Kandiloğlu, Ali Rıza; Koyuncu, Faik Mümtaz

doi:10.5152/jtgga.2011.37

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Also, in the study of Ozler (2011), no difference was noticed in the intensity of staining among proliferative, secretory, and hyperplastic endometrium ( P <0.05), therefore, it was concluded that leptin does not play a role in the hyperplastic change of the endometrium ( 29 ). This result was contrary to our results.…”

Section: Discussionmentioning

confidence: 95%

The Relationship Between Leptin Receptor Expression and Endometrial Carcinoma; A Case-Control Study

Sehhat,

Moshfegh Arani,

Lajevardi

et al. 2023

Iran J Pathol

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Background & Objective: Endometrial carcinoma is one of the most common malignancies in women in developed countries and the four th malignancy in Iranian women. Therefore, the identification of its causative factors is essential for the prevention, diagnosis, and treatment. This study was aimed to compare the leptin receptor (Ob-R) expression in the endometrial carcinoma cases and non-carcinoma samples. Methods: In this case-control study, 89 samples (including 45 carcinoma and 44 non-carcinoma samples) were examined. The carcinomatous samples were selected by the census method and others were selected with random method. The data were obtained from histopathologic diagnosis, immunohistochemistry (negative, positive and intensity of immunoreactivity), age, history of diabetes, and hypertension. Ob-R expression was compared in the studied groups using Chi-square, Fisher tests and Multivariate logistic regression analysis. In all tests the level of significance was set at 0.05. The SPSS 26 was used for data analysis. Results: The frequency of high levels of leptin receptors in the patients with endometrial carcinoma was significantly higher compared to the control group (57.8% vs. 2.3%) ( P <0.05). Adjusting the effects of age, history of diabetes mellitus (DM) and hypertension (HTN) revealed that the positive-receptor group had 37.75 (95% CI; 5.18-275.04) odds of having endometrial carcinoma ( P <0.001). Conclusion: The leptin receptor may be a risk factor for the endometrial carcinoma among women tested in Kashan. Based on these results, leptin receptor might be considered as a potential biomarker for screening the endometrial carcinoma or targeting the therapeutic purposes.

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Section: Discussionmentioning

confidence: 95%

The Relationship Between Leptin Receptor Expression and Endometrial Carcinoma; A Case-Control Study

Sehhat,

Moshfegh Arani,

Lajevardi

et al. 2023

Iran J Pathol

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“…Epidemiologic studies suggest that the risk of progression to malignancy is low for hyperplasia without atypia, whereas atypia is associated with a significant risk of carcinoma. Despite numerous studies on endometrial tumorigenesis, little is known about the cause of progression from endometrial hyperplasia to carcinoma [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study

Öztürk¹,

Pehlıvan

Balat

et al. 2018

Med Sci Monit Basic Res

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BackgroundIn this study, we aimed to evaluate the association between endometrial hyperplasia and DNA repair gene (XPD, XRCC4, and XRCC1) polymorphisms.Material/MethodsThere were 114 cases enrolled in the study in 4 groups: simple endometrial hyperplasia (SH) (Group 1), complex endometrial hyperplasia without atypia (CH) (Group 2), complex atypical endometrial hyperplasia (CAH) (Group 3), and normal endometrium (NE) (Group 4). Of these cases, 37 cases had SH, 36 cases had CH, 16 cases had CAH, and 25 cases had NE. To evaluate an association between atypia and DNA repair genes, we consider a group that included both SH and CH, the endometrial hyperplasia without atypia cases (Group 5). Genomic DNA was isolated from paraffin-embedded endometrial tissue collected from the Pathology Department of Gaziantep University Medical School. Polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) method was used for evaluating of XPD (−751), XRCC4 (−1394 and a variable number of tandem repeats in intron 3), and XRCC1 (−399) genes.ResultsWe observed a notable distinction in patients having endometrial hyperplasia without atypia (the SH+CH group) and the CAH group in terms of XPD (−751) gene polymorphisms. A notable contrast was observed in patients with endometrial hyperplasia without atypia (the SH+CH group) and the NE group in terms of XRCC4 (VNTR intron 3) polymorphisms (P=0.026, P=0.018, respectively).ConclusionsIt was evident the DNA repair gene XPD and XRCC4 polymorphisms had a role in the pathophysiology of endometrial hyperplasia.

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“…The majority of these tumors are of the endometrioid type that are typically hormone sensitive and have an excellent prognosis. Although hormonal and genetic association studies have been performed, the pathophysiology of ECa is still unclear (2)(3)(4). Nitric oxide synthase (NOS), which has three isoforms, catalyzes the oxidation of L-arginine to nitric oxide (NO) and citrulline.…”

Section: Introductionmentioning

confidence: 99%

Association of endothelial nitric oxide synthase gene polymorphisms with endometrial carcinoma: a preliminary study

Öztürk¹,

Dıkensoy²,

Balat³

et al. 2011

J Turkish German Gynecol Assoc

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Objective: To investigate the relationship between specific endothelial nitric oxide synthase (eNOS) gene polymorphisms and endometrial cancer (ECa). Material and Methods:The study group consisted of 89 patients histologically diagnosed with the endometrioid type of endometrial carcinoma. The control group consisted of 60 randomly selected individuals who had undergone total hysterectomy. Genomic DNA was isolated from paraffin-embedded endometrial tissues. We investigated the G894T polymorphisms (G894T) and variable number tandem repeats polymorphisms in intron 4 (VNTR intron 4) in the eNOS gene by using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP). The genotype distributions and allele frequencies of the two groups were compared. Results: Analysis of the VNTR intron 4 polymorphisms in eNOS generevealed that the frequency of the AA genotype was significantly higher in the control group, whereas the frequency of the BB genotype was significantly higher in the ECa group. Analysis of the G894T polymorphisms in eNOS gene revealed a significantly higher frequency of the GG genotype in the control group but a significantly higher frequency of the TT genotype in the endometrial cancer group. Key words: eNOS gene polymorphisms, endometrial carcinoma Received: 21 August, 2011 Accepted: 11 September, 2011 Amaç: Endometrium kanseri ile Endotelyal Nitrik Oksit Sentetaz (eNOS) gen polimorfizmi arasındaki ilişkinin ortaya konulması. Conclusion: Gereç ve Yöntemler:Araştırmaya endometrioid tip endometrial karsinom tanısı almış 89 hasta çalışma grubu olarak, diğer benign sebeplerle total histerektomi uygulanmış 60 hasta kontrol grubu olarak dahil edilmiştir. Genomik DNA endometrial dokuların parafin bloklarından elde edilmiştir. Bu çalışmada eNOS geninin G894T polimorfizmleri ve intron 4'deki değişken tekrarlayan dizi polimorfizmleri (VNTR intron 4) polimeraz zincir reaksiyonu (PCR) ve/veya enzim kesimi (RFLP) ile değerlendirilmiştir.Bulgular: eNOS geninin VNTR intron 4 gen polimorfizmi değerlen-dirildiğinde AA genotip sıklığı kontrol grubunda istatistiksel olarak anlamlı ölçüde yüksek saptanırken, BB genotip sıklığı endometrial kanser grubunda yüksek olarak izlenmiştir. eNOS geninin G894T polimorfizminde ise GG genotip sıklığı kontrol grubunda yüksek izlenirken TT genotip sıklığı hasta grubunda istatistiksel olarak anlamlı ölçüde yüksek olarak saptanmıştır.

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Leptin expression in proliferative, secretory and hyperplastic endometrial tissues

Cited by 4 publications

References 22 publications

The Relationship Between Leptin Receptor Expression and Endometrial Carcinoma; A Case-Control Study

The Relationship Between Leptin Receptor Expression and Endometrial Carcinoma; A Case-Control Study

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study

Association of endothelial nitric oxide synthase gene polymorphisms with endometrial carcinoma: a preliminary study

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