Leptin in human physiology and therapeutics

Dardeno, Tina A.; Chou, Sharon H.; Moon, Hee Sun; Chamberland, John P.; Fiorenza, Christina G.; Mantzoros, Christos S.

doi:10.1016/j.yfrne.2010.06.002

Cited by 247 publications

(219 citation statements)

References 272 publications

(453 reference statements)

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“…The finding that Mup levels rise to higher than AL control levels after RF, whereas nuclear GR levels fall to lower than control levels under the same conditions also points to the notion that there could be an inverse relationship of glucocorticoid levels and Mup transcription. In this context, it is interesting to note that glucocorticoid release could be induced by falling leptin levels [43]. Leptin is an adipocytederived hormone with a key role in regulating energy metabolism [48].…”

Section: Discussionmentioning

confidence: 99%

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

et al. 2013

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Major urinary proteins (Mups) are important for rodent scent communication and sexual behaviour. Recent evidence suggests that Mup1 may be regulated by fasting and re-feeding (RF). However, other Mup isoforms are poorly investigated, and data on the impact of long-term dietary restriction (DR) and ad libitum RF on Mup expression are missing. We investigated the effects of long-term 25 per cent DR and subsequent RF on Mup expression in male C57BL6 mice. DR significantly decreased Mup gene expression, hepatic and urinary protein levels compared with ad libitum (AL) fed control mice, with the greatest downregulation found for Mup5 expression. The decline in Mup expression was inverted by six months of RF. Because of inhibitory glucocorticoid response elements in the genomic sequence of the Mup5 gene, the observed inverse correlation of nuclear glucocorticoid receptor levels with Mup expression in response to DR and subsequent RF is a possible regulatory mechanism. Additionally, gene-expression-inhibiting histone deacetylation (H3K9) occurred in the region of the Mup5 gene in response to DR. We assume that Mup may act as a molecular switch linking nutritional status to sexual behaviour of mice, and thereby regulating male fertility and reproduction in response to food supply.

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Section: Discussionmentioning

confidence: 99%

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

et al. 2013

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“…Leptin is known to increase a er glucocorticoid administration and in Cushing's syndrome [33,34]. Leptin is a cytokine and is found at signi cantly higher levels in women with metabolic syndrome [35], so it could be hypothesized that it has more in uence on HPA axis in women. Consistent with this hypothesis, this study found a signi cant positive correlation between serum cortisol and leptin levels in women with metabolic syndrome.…”

mentioning

confidence: 99%

Association of serum cortisol levels with parameters of metabolic syndrome in men and women

Esteghamati¹,

Morteza²,

Khalilzadeh³

et al. 2011

CIM

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Association of serum cortisol levels with parameters of metabolic syndrome in men and women Abstract Purpose: Central fat distribution is signi cantly associated with an increased cortisol levels. We hypothesized that men with metabolic syndrome have a higher serum cortisol levels compared to women. e purpose of this study was to compare serum cortisol levels, and its correlation with serum leptin levels, between men and women with and without metabolic syndrome.Methods: A cross sectional study was performed with 120 untreated patients with metabolic syndrome and 165 healthy volunteers as controls. Serum lipid pro le, fasting blood sugar, insulin, cortisol and leptin levels were measured for both groups.Results: Men with metabolic syndrome had a higher serum cortisol levels, while serum leptin levels were signi cantly higher in women. e higher serum cortisol level in men with metabolic syndrome was signi cant a er multiple adjustments for age, BMI and waist circumference (17.74±5.1 vs 14.07±4.3; p<0.05) using general linear model; however, these di erence were no longer signi cant when the waist-to-hip ratio was added as one of the adjustment factors (16.7±1.2 vs. 14.9±0.5; p<0.2). Serum cortisol levels was signicantly correlated with serum leptin (r=0.33, p<0.05), cholesterol (r=0.35, p<0.05), triglyceride (r=0.25, p<0.05), waist circumference (r=0.41, p<0.01) and waist-to-hip ratio (r=0.32, p<0.01) in women with metabolic syndrome, a er controlling for age and BMI.Conclusion: Serum cortisol levels are signi cantly higher in men with metabolic syndrome. is e ect is independent of waist circumference. ORIGINAL RESEARCH © 2011 CIMClin In E131 Metabolic syndrome is a cluster of metabolic risk factors associated with cardiovascular disease and type 2 diabetes [1]. e major components of metabolic syndrome include excess abdominal fat, dyslipidemia, hypertension, hyperglycemia and increased in ammatory state [1]. For any given body mass index (BMI), mortality is higher if fat is distributed centrally, which is the major component of metabolic syndrome [2]. Cross-sectional studies showed that morning cortisol levels are signi cantly correlated with the symptoms of metabolic syndrome, such as visceral obesity, high blood pressure and a poor lipid pro le [3][4][5]. Further studies suggest that metabolic syndrome is a less profound form of Cushing's syndrome, which is characterized by a rise in serum cortisol levels [4,[6][7][8][9].is hypothesis is based on the simple observation that patients with Cushing's syndrome develop central obesity, which improves with the resolution of hypercortisolism [10,11].It is known that men with metabolic syndrome are more frequently a ected with android obesity. Central fat distribution is signi cantly associated with increased cortisol levels [12,13], so it could be hypothesized that men with metabolic syndrome have a higher serum cortisol levels, due to increased abdominal obesity compared with women. On the other hand, adipose tissue is known as an endocrine organ, producing a number...

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“…It has been reported to play an important role in regulation of body weight, fat metabolism, and glucose uptake [11,15]. Patients with T2DM showed decreased LEP expression in adipose tissue, and had lower serum LEP levels [16]. LEP modulates insulin secretion and action via LEPRs present in the hypothalamus, pancreatic cells, adipose tissue, and muscles [17].…”

Section: Discussionmentioning

confidence: 99%

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

Kim¹,

Ihm²,

Lee³

et al. 2017

Transplant Open

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Background: Post-transplant diabetes mellitus (PTDM) is a common and important metabolic complication after renal transplantation. Although genetic variants of the leptin (LEP) and leptin receptor (LEPR) gene have been reported to be associated with insulin resistance and diabetes mellitus, few studies have examined these variants in patients with post-transplant diabetes mellitus (PTDM). In this study, we investigated the association between LEP and LEPR polymorphisms and PTDM in renal transplant recipients. We also reviewed the literature on the genetic variants associated with development of PTDM.

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Leptin in human physiology and therapeutics

Cited by 247 publications

References 272 publications

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

Association of serum cortisol levels with parameters of metabolic syndrome in men and women

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

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