Leptin in the canine uterus and placenta: possible implications in pregnancy

Balogh, Orsolya; Staub, Livia; Gram, Aykut; Boos, Alois; Kowalewski, Mariusz P.; Reichler, Iris M

doi:10.1186/s12958-015-0003-6

Cited by 22 publications

(29 citation statements)

References 75 publications

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“…Interestingly, human (Dötsch et al, ) rat (Kawai et al, ), and murine (Hoggard et al, ) placenta were found to be a source of leptin. More recently, Balogh et al () reported the gene expression of leptin and leptin receptor in the placenta of dogs.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Balogh et al () reported the expression of leptin and leptin receptor in the foetal and maternal sides of the placenta over the course of pregnancy. Their presence indicates multiple paracrine/autocrine functions (Balogh et al, ). Our study may also provide further data for an endocrine role of leptin during pregnancy Further studies are needed to assess the role of placental and foetal production of leptin and its influence on maternal plasma concentrations regulation of BW and control of food intake as reported for other species (Hoggard et al, ; Linnemann et al, ; Hauguel‐de et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…More recently, Balogh et al () reported that leptin and its receptor were expressed in the uterus and placenta of pregnant dogs while Cardinali et al () reported an increase in leptin concentration during bitch's gestation. In this publication, the authors describe a profile of leptin similar to that already reported in humans (Hardie, Trayhurn, Abramovich, & Fowler, ), rats (Tomimatsu et al, ) and rabbits (Menchetti et al, ) characterized by a gradual increase in serum levels during the first half of the pregnancy to reach peak concentrations halfway through gestation.…”

Section: Introductionmentioning

confidence: 99%

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Serum concentrations of leptin in pregnant and non‐pregnant bitches

Troisi

Cardinali

Menchetti

et al. 2020

Reprod Domestic Animals

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Leptin regulates body weight and several physiological processes including reproduction. We evaluated the circulating levels of leptin in pregnant and non‐pregnant bitches as well as their correlation with body weight, food intake and number of foetuses. Nineteen healthy German shepherd bitches were used and divided in two groups (pregnant n = 12 and non‐pregnant n = 7). Blood samples were collected every 15 days starting from ovulation (Day 0) throughout pregnancy (pregnant group, P) or throughout luteal phase (non‐pregnant group, NP) In pregnant bitches, leptin concentrations increased from the day of ovulation (1.32 ± 0.06 ng/ml) up to day 45 (1.51 ± 0.06 ng/ml; p < .01) and returned to baseline values from day 60 post‐ovulation. In non‐pregnant bitches, leptin concentrations remained constant throughout the whole observation period (estimated marginal mean ± SE=1.33 ± 0.38 ng/ml). Pairwise comparisons showed significant differences between P and NP at day 45 post‐ovulation (p < .05). Multivariable models indicated that, controlling for time and litter size, there was a positive relationship between leptin concentration and BW (p < .05) although Pearson coefficients showed that the correlation between BW and leptin was only significant in NP animals at day 45 (r = 0.76, p < .05). The multivariable approach also suggested that, holding BW and time constant, leptin concentrations tend to increase as the number of puppies increased (p = .06). Our study supports indirectly the contribution of the feto‐placental unit to the circulating maternal leptin concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum concentrations of leptin in pregnant and non‐pregnant bitches

Troisi

Cardinali

Menchetti

et al. 2020

Reprod Domestic Animals

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“…Además, se ha descrito un descenso en las concentraciones séricas de leptina hacia el final de la gestación (Cardinali et al, 2017), así como también la expresión de genes de leptina (Lep) y de receptores Lep en úte-ro y placenta canina (Balogh et al, 2015), postulándose que el sistema de señalización de Lep tendría un rol en el mecanismo de parto de esta especie.…”

Section: Partounclassified

Biología Gestacional y Predicción del Parto en la Perra

Riquelme

Ruiz

2017

Rev. investig. vet. Perú

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RESUMENLa gestación en la perra transcurre entre la fecundación y el parto, y su duración tiene importancia clínica. La compleja biología de los gametos y embriones influye en la duración de la gestación, cuyo lapso fisiológico fluctúa entre los 57 y 70 días. Este amplio rango puede estar influenciado por los métodos referenciales para la estimación del inicio de la gestación. El realizar montas o inseminaciones en base a detección de la ovulación permite estrechar el rango a 62 a 64 días. Una condición de alto impacto obstétrico es la gestación de un solo cachorro, la cual es más prolongada y representa alto riesgo de distocia. Dada la importancia clínica de una adecuada proyección de la duración de la gestación y de la predicción de la fecha de parto, se han desarrollado fórmulas matemá-ticas para el cálculo de la edad fetal y tiempo al parto a través de la sistematización de la ultrasonografía gestacional.Palabras clave: perra; duración de gestación; parto ABSTRACTThe pregnancy in the bitch occurs between fertilization and whelping, and its length has clinical importance. The complex biology of the gametes and embryos influences the length of the gestation, where the physiological period fluctuates from 57 to 70 days. This wide range can be influenced by the referential methods used to estimate the starting day. Controlled natural mating or artificial insemination based on the detection of ovulation allows reducing the range from 62 to 64 days. A high impact obstetric condition is the

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Canine Endotheliochorial Placenta: Morpho-Functional Aspects

Kowalewski

Kazemian

Klisch

et al. 2021

Advances in Anatomy, Embryology and Cell Biology

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In the domestic dog placentation arises from central implantation, passing through a transitional, yet important stage of choriovitelline placenta (yolk sac placenta), on the way to the formation of the definite, deciduate, zonary (girdle) allantochorionic endotheliochorial placenta. Sharing some similarities with other invasive types of placentation, e.g. by revealing decidualization, it is characterized by restricted (shallow) invasion of trophoblast not affecting maternal capillaries and maternal decidual cells. Thus, being structurally and functionally placed between non-invasive epitheliochorial placentation and the more invasive hemochorial type, it presents an interesting and important model for understanding the evolutionarily determined aspects of mammalian placentation. More profound insights into the biological mechanisms underlying the restricted invasion of the fetal trophoblast into maternal uterine structures and the role of decidual cells in that process, could provide better understanding of some adverse conditions occurring in humans, like preeclampsia or placenta accreta. As an important endocrine organ actively responding to ovarian steroids and producing its own hormones, e.g. serving as the source of gestational relaxin or prepartum prostaglandins, the canine placenta has become an attractive research target, both in basic and clinical research. In particular the placental feto-maternal communication between maternal stroma-derived decidual cells and fetal trophoblast cells (i.e. an interplay between placenta materna and placenta fetalis) during the maintenance and termination of canine pregnancy, serves as an interesting model for induction of parturition in mammals and is an attractive subject for translational and comparative research. Here, an updated view on morpho-functional aspects associated with canine placentation is presented.

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Leptin in the canine uterus and placenta: possible implications in pregnancy

Cited by 22 publications

References 75 publications

Serum concentrations of leptin in pregnant and non‐pregnant bitches

Serum concentrations of leptin in pregnant and non‐pregnant bitches

Biología Gestacional y Predicción del Parto en la Perra

Canine Endotheliochorial Placenta: Morpho-Functional Aspects

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