Leptin Influences Cellular Differentiation And Progression In Prostrate Cancer

Abstract

Leptin may have roles in the development of prostate cancer through testosterone and factors related to obesity. It influences cellular differentiation and the progression of prostate cancer.

The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

“…66,67 However, it was found that higher leptin levels were linked to tumor progression and advanced disease. 38,68 We conclude from these investigations that leptin may be predominantly relevant in PCa progression. Studies on this issue should evaluate the grade and stage of PCa patients.…”

Leptin and cancer

“…Hsing et al (2001) found that prostate cancer risk is associated with higher leptin levels and with WHR values above 0.87, which suggested that leptin could interact with humoral factors related to abdominal obesity, such as sex hormones, insulin and IGF-1, to increase the risk of prostate cancer. Interestingly, two studies that examined serum leptin in men with prostate cancer reported that higher leptin levels were associated with more advanced tumors, characterized by larger size and higher grade Saglam et al, 2003). However, several other studies concluded that circulating leptin is not associated with prostate cancer (Lagiou et al, 1998;Hsing et al, 2001;Stattin et al, 2003a).…”

“…Several authors noted a positive correlation between serum leptin and prostate cancer risk (Stattin et al, 2001;Saglam et al, 2003). Hsing et al (2001) found that prostate cancer risk is associated with higher leptin levels and with WHR values above 0.87, which suggested that leptin could interact with humoral factors related to abdominal obesity, such as sex hormones, insulin and IGF-1, to increase the risk of prostate cancer.…”

Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men

“…For example, several studies report that obesity is associated with the stage of cancer at detection, 11,12 and a metaanalysis from MacInnis and English estimated that each 5-unit increase in BMI was associated with an approximate 5% increase in the risk of developing advanced prostate cancer. 12 Furthermore, clinical prostate cancer risk has been associated with the metabolic syndrome, 13,14 centralized obesity, 15 leptin levels [16][17][18] and insulin resistance. 19,20 However, several studies report no evidence of an association, [21][22][23][24][25][26][27] while others report that BMI is associated with reduced risk of prostate cancer, particularly low-grade tumors.…”