Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells

Shouman, Samia A.; Wagih, Mohamed; Kamel, Marwa

doi:10.20892/j.issn.2095-3941.2016.0079

Cited by 16 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…com.mx open www.nature.com/scientificreports www.nature.com/scientificreports/ of cancer cells and not of normal breast cells, which is indicative that leptin participates directly in the development of this type of cancer 8,9 .…”

mentioning

confidence: 99%

Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen

Linares

Benítez

Reynoso

et al. 2019

Sci Rep

View full text Add to dashboard Cite

one of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. in this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice. The modulation evaluation of leptin receptor expression in the presence of leptin and tamoxifen stimuli was performed in breast cancer cell lines MCF 7, MDA MB 231 and HCC 1937 as a model of initial approach for the study of breast cancer subtypes and their behavior to the action response of adipokines and their possible relationship with the mechanism of resistance to chemotherapeutics such as tamoxifen in eR positive cell lines and triple negative marker. it was determined that leptin increases the proliferation of the three breast cancer cell lines and tamoxifen is able to exert an antiproliferative effect on them, however, it was identified that the ability of tamoxifen to decrease the proliferation of cancer cells is diminished in the presence of leptin, in addition to changes in the modulation of the expression of its receptor. it was determined that tamoxifen induces a greater modulation of the expression of obRb in cell lines, which may be related to the decrease of its antiproliferative activity, while leptin generates a proliferative effect in the three cell lines and could participate in the tamoxifen treatment resistance mechanism.

show abstract

mentioning

confidence: 99%

Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen

Linares

Benítez

Reynoso

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Obesity has a more serious impact on postmenopausal women than premenopausal women suffering from breast cancer (13,18), which is caused by the different levels of estrogen secretion, and leptin plays a key role in this process. Leptin increases the risk of breast cancer by increasing the effect of hormone secretion on breast tissue hyperplasia, which is more significant in postmenopausal women (22). Before menopause, the body maintains a balance of estrogen levels through the negative feedback regulation mechanism of the hypothalamus-pituitary-gonad axis.…”

Section: Leptin and Tumorigenesismentioning

confidence: 99%

Targeting Adipokines in Obesity-Related Tumors

Chen

2021

Front. Oncol.

View full text Add to dashboard Cite

Obesity, a global epidemic, is an independent risk factor for the occurrence and development of a variety of tumorigenesis, such as breast cancer, pancreatic cancer, ovarian cancer and colorectal cancer. Adipocytes are important endocrine cells in the tumor microenvironment of obesity-related tumors, which can secrete a variety of adipokines (such as leptin, adiponectin, estrogen, resistin, MIF and MCP-1, etc.), among which leptin, adiponectin and estrogen are the most in-depth and valuable ones. These adipokines are closely related to tumorigenesis and the progression of tumors. In recent years, more and more studies have shown that under chronic inflammatory conditions such as obesity, adipocytes secrete more adipokines to promote the tumorigenesis and development of tumors. However, it is worth noting that although adiponectin is also secreted by adipocytes, it has an anti-tumor effect, and can cross-talk with other adipokines (such as leptin and estrogen) and insulin to play an anti-tumor effect together. In addition, obesity is the main cause of insulin resistance, which can lead to the increase of the expression levels of insulin and insulin-like growth factor (IGF). As important regulators of blood glucose and lipid metabolism, insulin and IGF also play an important role in the progress of obesity related tumors. In view of the important role of adipokines secreted by adipocytes and insulin/IGF in tumors, this article not only elaborates leptin, adiponectin and estrogen secreted by adipocytes and their mechanism of action in the development of obesity- related tumors, but also introduces the relationship between insulin/IGF, a regulator of lipid metabolism, and obesity related tumors. At the same time, it briefly describes the cancer-promoting mechanism of resistin, MIF and MCP-1 in obesity-related tumors, and finally summarizes the specific treatment opinions and measures for various adipokines and insulin/insulin-like growth factors in recent years.

show abstract

“…Furthermore, leptin is known to upregulate CYP1B1 expression in breast cancer cells. 127 Therefore, the increase in leptin levels in obesity may contribute to the increase in CYP1B1 expression observed. We have shown that CYP1B1 is also highly expressed in adipose tissue, and thoracic adipose tissue from obese mice produces 16OHE1.…”

Section: Adipose-derived Estrogens and Pahmentioning

confidence: 99%

“… 130 , 131 The adipokine leptin has been shown to decrease COMT expression in breast cancer cells. 127 Therefore, the increased leptin levels observed in obesity may result in a reduction in COMT and a decrease the levels of the 2MeOE2, thus attenuating its protective effects on the pulmonary circulation and resulting in a more proproliferative environment that contributes to the development of PAH.…”

Section: Adipose-derived Estrogens and Pahmentioning

confidence: 99%

Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension

2020

View full text Add to dashboard Cite

Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and resistin. Obesity is a common comorbidity amongst pulmonary arterial hypertension patients, with 30% to 40% reported as obese, independent of other comorbidities associated with pulmonary arterial hypertension (e.g. obstructive sleep apnoea). An ‘obesity paradox’ has been observed, where obesity has been associated with subclinical right ventricular dysfunction but paradoxically may confer a protective effect on right ventricular function once pulmonary hypertension develops. Obesity and pulmonary arterial hypertension share multiple pathophysiological mechanisms including inflammation, oxidative stress, elevated leptin (proinflammatory) and reduced adiponectin (anti-inflammatory). The female prevalence of pulmonary arterial hypertension has instigated the hypothesis that estrogens may play a causative role in its development. Adipose tissue, a major site for storage and metabolism of sex steroids, is the primary source of estrogens and circulating estrogens levels which are elevated in postmenopausal women and men with pulmonary arterial hypertension. This review discusses the functions of adipose tissue in both health and obesity and the links between obesity and pulmonary arterial hypertension. Shared pathophysiological mechanisms and the contribution of specific fat depots, metabolic and sex-dependent differences are discussed.

show abstract

Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells

Cited by 16 publications

References 35 publications

Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen

Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen

Targeting Adipokines in Obesity-Related Tumors

Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension

Contact Info

Product

Resources

About