Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression

Pan, Yunbao; Zhou, Fuling; He, Chenyan; Hui, Lingyun; Huang, Tianhe; Wei, Yongchang

doi:10.1155/2017/6482842

Cited by 9 publications

(13 citation statements)

References 47 publications

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“…Additionally, cancer-related depression can be evoked by cancer-independent mechanisms due to the impact of cancer diagnosis and stress [123]. Another probable mechanism, responsible for the development of cancer-related depression, is the upregulation of the leptin receptor, as observed in the gastric tissue of depressive gastric cancer patients, demonstrating that leptin may be involved in the pathogenesis of cancer-associated depression [124].…”

Section: Major Depression Disorder (Mdd)mentioning

confidence: 99%

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

2019

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Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4. Cancer patients undergo complications, such as anorexia-cachexia syndrome, pain, depression, and paraneoplastic syndromes. Interestingly, the 2017 European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines for cancer patients only discuss the use of omega-3 PUFAs for cancer-cachexia treatment, leaving aside other cancer-related complications that could potentially be managed by omega-3 PUFA supplementation. This critical review aimed to discuss the effects and the possible underlying mechanisms of omega-3 PUFA supplementation in cancer-related complications. Data compilation in this critical review indicates that further investigation is still required to assess the factual benefits of omega-3 PUFA supplementation in cancer-associated illnesses. Nevertheless, preclinical evidence reveals that omega-3 PUFAs and their metabolites might modulate pivotal pathways underlying complications secondary to cancer, indicating that this is a promising field of knowledge to be explored.

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Section: Major Depression Disorder (Mdd)mentioning

confidence: 99%

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

2019

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“…SIRT1 and phosphoinositide 3-kinase (PI3K), for instance, are activated in both GC and depression [16, 18]. In our previous work, we found that ABL1 was upregulated in patients with both GC/colorectal carcinoma and depression [19, 20], and some kinds of cytokines like Leptin-LepRb and COX2 are abnormally expressed [21, 22]. Given the role of ROS in depression, GC, and crosstalk with inflammation, we speculated that ROS, ABL1, and inflammation are involved in the development of GC as well as GC-related depression.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway

Huang

Zhou

Yuan

et al. 2019

Oxidative Medicine and Cellular Longevity

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Background. The mechanisms of crosstalk between depression and gastric cancer (GC) remain ill defined. Given that reactive oxygen species (ROS) is involved in the pathophysiology of both GC and depression, we try to explore the activities of ROS in the development of GC and GC-related depression. Methods. 110 patients with newly diagnosed GC were recruited in our study. The clinical characteristics of these patients were recorded. Inflammation and oxidative stress markers were detected by ELISA. The depression status of patients with GC was assessed during follow-up. The association between ROS, ABL1, and inflammation factors was evaluated in H2O2-treated GC cell lines and The Cancer Genome Atlas (TCGA) database. The effect of ABL1 on inflammation was detected with Imatinib/Nilotinib-treated GC cell lines. A chronic mild stress- (CMS-) induced patient-derived xenograft (PDX) mice model was established to assess the crosstalk between depression and GC. Results. Depression was correlated with poor prognosis of patients with GC. GC patients with depression were under a high level of oxidative status as well as dysregulated inflammation. In the CMS-induced GC PDX mice model, CMS could facilitate the development of GC. Additionally, tumor bearing could induce depressive-like behaviors of mice. With the treatment of ROS, the activities of ABL1 and inflammatory signaling were enhanced both in vitro and in vivo, and blocking the activities of ABL1 inhibited inflammatory signaling. Conclusions. ROS-activated ABL1 mediates inflammation through regulating NF-κB1 and STAT3, which subsequently leads to the development of GC and GC-related depression.

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“…Pan et al published a clinical trial reporting that both serum and tissue leptin-LepRb are higher in depressive than in non-depressed patients with GC ( 41 ). Leptin is a hormone primarily produced in white adipose tissue and secreted into the plasma.…”

Section: Discussionmentioning

confidence: 99%

Influencing Factors and Effects of Treatment on Quality of Life in Patients With Gastric Cancer—A Systematic Review

Rupp¹,

Stengel

2021

Front. Psychiatry

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Background: Gastric cancer (GC) is one of the leading causes of death worldwide. It is associated with several disease-related impairments contributing to the psycho-social burden of those patients, such as deterioration of well-being and overall quality of life (QOL). The aim of this study is to present the wide range of factors potentially impacting patients' overall well-being and possible preventive interventions.Methods: This systematic review was conducted in October 2020 with a search in the PubMed, MedLine, PsycInfo, and Google Scholar databases. We used the keywords “gastric cancer,” “gastric neoplasm,” and each of them combined with “quality of life,” “depression,” and “anxiety” to identify all relevant articles reporting about potential impact factors influencing the overall well-being of patients suffering from gastric cancer.Results: Finally, 125,490 articles were found, of which 125,431 were excluded in several steps of screening. Inclusion criteria were studies carried out on human ≥18 years of age, studies in English or German language, clinical trials, registry-based studies, cohort studies, population-based studies, and certain titles and abstracts. After screening for eligibility 35 potential factors influencing overall well-being in patients with GC were identified and classified into 9 important categories: genetic condition, treatment method, blood markers, nutritional status, daily living, state of health, mental state, supportive care, and alternative treatment.Conclusion: Since various factors are involved in the development of patients' overall well-being, timely treatment of psycho-social impairments by physicians and psychologists is of enormous importance. Preventing psycho-social burden by improving patients' QOL should be of high importance in the treatment regimen of patients with GC.

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Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression

Cited by 9 publications

References 47 publications

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway

Influencing Factors and Effects of Treatment on Quality of Life in Patients With Gastric Cancer—A Systematic Review

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