Leptin levels in breast‐fed infants

Savino, Francesco; Liguori, Stefania Alfonsina; Lupica, MM; Fissore, Maria Francesca; Oggero, R

doi:10.1111/j.1365-2265.2006.02486.x

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…This study showed higher serum leptin levels in BF infants than in FF infants, confirming the results of our previous studies in infancy . However, the reason for these higher serum leptin levels in BF infants is not completely understood.…”

Section: Discussionsupporting

confidence: 90%

High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants

et al. 2013

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Section: Discussionsupporting

confidence: 90%

High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants

et al. 2013

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“…A positive correlation has also been reported between breast milk leptin levels and infant plasma leptin 49 . We have observed higher serum leptin concentrations in BF infants than in FF babies in the first months of life 50,51 and also a positive correlation between serum leptin concentration in BF infants and maternal BMI 52 …”

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confidence: 76%

Can hormones contained in mothers’ milk account for the beneficial effect of breast‐feeding on obesity in children?

Savino

Fissore

Liguori

et al. 2009

Clinical Endocrinology

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SummaryNutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adipokines (leptin and adiponectin), ghrelin, resistin and obestatin, which are involved in food intake regulation and energy balance. These compounds are either not found in commercial milk formulas or their presence is still controversial. Diet-related differences during infancy in serum levels of factors involved in energy metabolism might explain anthropometric differences and also differences in dietary habits between breastfed (BF) and formula-fed (FF) infants later in life, and may thus have long-term health consequences. In this context, the recent finding of higher leptin levels and lower ghrelin levels in BF than in FF infants suggests that differences in hormonal values together with different protein intake could account for the differences in growth between BF and FF infants both during infancy and later in life. In this review, we examine the data related to hormones contained in mothers' milk and their potential protective effect on subsequent obesity and metabolicrelated disorders.

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“…It has been observed that a postnatal surge in plasma leptin might serve as a key developmental signal (Bouret and Simerly, 2006). Some studies in literature suggest a relationship between leptin levels in BM and serum leptin concentration in lactating mothers, probably because of the ability of leptin to be transferred from serum to BM (Houseknecht et al, 1997;Weyermann et al, 2006), and we recently observed a higher leptin concentration in BF infants than in artificially fed ones (Savino et al, 2005(Savino et al, , 2006.…”

Section: Introductionmentioning

confidence: 73%

Evaluation of leptin in breast milk, lactating mothers and their infants

et al. 2010

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Background/Objectives: Leptin is present in human milk, but it is not clear what the relationship between breast milk (BM) leptin levels and maternal and infant serum leptin concentrations is. The objective of this study was to evaluate the leptin concentration in BM and to investigate its relationship with infants' and mothers' anthropometric parameters and with serum leptin concentration in breast-fed (BF) infants and lactating mothers. Subjects/Methods: We enrolled 36 adequate for gestational age healthy, exclusively BF, term infants aged o6 months. Leptin concentration in serum and BM was determined by radioimmunoassay (RIA) test (human-leptin-RIA-sensitive, Mediagnost). Infants' and mothers' weights, lengths and body mass indexes (BMI) were measured. Results: The median leptin concentration was 3.42 ng/ml (interquartile range (IR): 2.65) in BF infants' serum, 3.02 ng/ml (IR: 2.85) in mothers' serum (n ¼ 17) and 0.51 ng/ml (IR: 0.34) in BM (n ¼ 24). BM leptin concentrations were significantly lower than serum BF infant (Po0.001) and maternal (Po0.001) leptin levels. Infant serum leptin concentration correlated positively with infant weight (r ¼ 0.437, P ¼ 0.008) and BMI (r ¼ 0.561, P ¼ 0.004). Mother serum leptin levels correlated positively with weight (r ¼ 0.755, Po0.001) and BMI (r ¼ 0.661, P ¼ 0.007). No correlations were found between BM leptin and serum leptin concentrations in BF infants and mothers. Conclusions: We confirmed the presence of leptin in BM at a lower concentration than that found in infant and lactating mother serum. We observed a positive correlation between serum leptin levels in BF infants and their growth parameters.

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Leptin levels in breast‐fed infants

Cited by 10 publications

References 13 publications

High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants

High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants

Can hormones contained in mothers’ milk account for the beneficial effect of breast‐feeding on obesity in children?

Evaluation of leptin in breast milk, lactating mothers and their infants

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