Leptin levels in children with malnutrition

Akib, Resky Devi; Aminuddin, Aminuddin; Hamid, Firdaus; Prihantono, Prihantono; Bahar, Burhanuddin; Hadju, Veni

doi:10.1016/j.gaceta.2021.10.033

Cited by 5 publications

(9 citation statements)

References 8 publications

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“…Leptin level was also higher in normoweight children, compared with underweight children. This finding was similar to another study that found significantly lower leptin levels in malnourished children [16]. Leptin was widely known to correlate with adiposity, increased appetite, and obesity [5,9,10].…”

Section: Discussionsupporting

confidence: 89%

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Association between Leptin, Adiponectin Levels, and Nutritional Status in Children with Down Syndrome

Utari

Panunggal

Rahardjo

et al. 2022

J. Intellect. Disabl. Diagn. Treat.

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Background: Children with Down Syndrome (DS) have been associated with obesity. Leptin and adiponectin were also significant predictors of obesity and its comorbidity in DS. However, there was limited data regarding leptin and adiponectin in children with DS, particularly who were undernutrition. This study aimed to seek the role of leptin levels, adiponectin levels, and nutritional status in children with DS. Methods: This cross-sectional study was conducted on 40 children with DS aged 1 - 5 years. Height and weight were measured, and then the growth was interpreted using a DS growth chart. The Weight for Height Z-Score (WHZ) and Height for Age Z-Score (HAZ) were determined, and Mid-Upper Arm Circumference (MUAC) was measured. Leptin and adiponectin serum were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. Mann-Whitney test was done to compare leptin and adiponectin levels in normal and wasted groups, while Spearman’s analysis was carried out to correlate laboratory results and anthropometric parameters. Results: Forty children participated (23 males, 17 females) with a median age was 25.5 months. Ten out of 40 children with DS (25%) were wasted and leptin was significantly lower in wasted compared to normal children. In addition, leptin was significantly correlated with WHZ (r = 0.415; p = 0.008), and MUAC (r = 0.427; p = 0.006), while adiponectin did not significantly correlate with those anthropometric variables in both wasted or non-wasted groups. Conclusion: Leptin is associated with WHZ and MUAC, and it decreases in wasted children with DS.

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Section: Discussionsupporting

confidence: 89%

“…Adiponectin also acts as an anti-inflammatory agent which protects the heart, lungs, vascular system, and colon [15]. In malnourished children, serum leptin was lower than those in normal-weight children because of losing adipose tissue [16]. Low leptin levels would disturb the metabolic, endocrine, and immune systems [17].…”

Section: Introductionmentioning

confidence: 99%

Association between Leptin, Adiponectin Levels, and Nutritional Status in Children with Down Syndrome

Utari

Panunggal

Rahardjo

et al. 2022

J. Intellect. Disabl. Diagn. Treat.

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show abstract

“…Akib et al (2) conducted their study and reported that the switch from nursing to breast milk substitute occurs at two years old, which makes this age the most susceptible to nutritional deficiencies, according to their study.…”

Section: Discussionmentioning

confidence: 98%

“…Total fat mass and leptin concentration are related, with leptin concentrations being greater in obese patients. A symptom of brain deprivation, the drop in leptin following calorie restriction may also have a protective impact (2) . Leptin, "thin," or the "satiety hormone", encoded by the obese (ob) gene, which has a mass of around 16 kDa.…”

Section: Introductionmentioning

confidence: 99%

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Serum Leptin Level Assay in Normal and Malnourished Children Aged from One to Five Years

Mousay¹,

Rashid²,

Halim³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Leptin may be connected to nutrition, malnutrition, and the control of the energy balance.Objective: This study aimed to assess the relationship between leptin levels and malnutrition status compared to normal nutrition in children aged from 12-60 months. Subjects and methods: This case-control study was carried out on 66 children in the Nutritional Department and Pediatrics Out-patients Clinic of Zagazig University Children Hospital. They were divided into two groups: Group I included 33 cases as normal nutritional status, and Group II included 33 cases with malnutrition status. Results: Between the study groups, there was a statistically significant decrease in serum leptin in malnourished group. Conclusion:The mean value of leptin levels was lower among malnutrition children than normal children.

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The interaction between neuroendocrine and immune systems in infants and children during under nutrition

Soliman¹,

Alaaraj²,

Yassin³

et al. 2023

World J. Adv. Res. Rev.

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Malnutrition remains an international concern because it represents a major cause of childhood morbidity and mortality. In infants and children malnutrition significant metabolic, hormonal, and immune changes occur with short- and long-term effects and outcomes. Thus, studies which contribute to the prevention, amelioration, or rehabilitation of the detrimental effect of malnutrition are necessary. Investigations on endocrine, metabolic, and immune changes related to severe malnutrition started a long time ago. However, recently there has been little work on these important changes, their mechanism/s of action and interactions, and their effect on different systems. The neuroendocrine system is the initial response to stress, so it is reasonable to assume that this system also plays a key role in the pathophysiological changes during nutritional deprivation. However, many of the newly identified functions/changes are better explained by the action of conventional neurotransmitters (e.g., glutamate and GABA) that constitute a neuronal circuit. In addition, the mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase has emerged as a sensor for nutrients that has a central joint in cellular metabolism, cell growth, and differentiation. Its functions during malnutrition in the central nervous system, endocrine system, and different end organs and tissues (liver, pancreas, muscle, and adipose tissue) need elucidation. This article presents a brief review of neuroendocrine changes during malnutrition and their effects on the modulation of metabolism, growth, and immune functions. The pros and cons of these endocrine changes are discussed as well as their reversibility on nutritional rehabilitation.

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Leptin levels in children with malnutrition

Cited by 5 publications

References 8 publications

Association between Leptin, Adiponectin Levels, and Nutritional Status in Children with Down Syndrome

Association between Leptin, Adiponectin Levels, and Nutritional Status in Children with Down Syndrome

Serum Leptin Level Assay in Normal and Malnourished Children Aged from One to Five Years

The interaction between neuroendocrine and immune systems in infants and children during under nutrition

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