Leptin levels in gingival crevicular fluid in periodontal health and disease

Karthikeyan, B V; Pradeep, A.R.

doi:10.1111/j.1600-0765.2006.00948.x

Cited by 73 publications

(107 citation statements)

References 25 publications

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“…26 Leptin expression is also seen in pulp samples, and it is found to increase during pulpal inflammation. 27 Recent studies evaluated leptin levels in gingival crevicular fluid during orthodontic tooth movement and found that the leptin level is decreased during orthodontic tooth movement.…”

Section: Introductionmentioning

confidence: 93%

Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

Jayachandran

Srinivasan

Padmanabhan

2017

The Angle Orthodontist

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Objectives: To assess and compare the concentration of leptin in saliva between normal weight and overweight individuals and to evaluate the rate of orthodontic tooth movement. Materials and Methods: Thirty female subjects were divided into two groups: I (normal weight) and II (overweight group) based on their body mass index. All subjects underwent fixed appliance therapy requiring upper first premolar extraction and distal movement of the canine. Distal force was applied to the maxillary right canine using active lacebacks. Salivary samples were collected just before force application (T 0 ), 1 hour (T 1 ), and 1 month (T 2 ) after force application. The rate of tooth movement was evaluated over 3 months and was measured on study models.

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Section: Introductionmentioning

confidence: 93%

Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

Jayachandran

Srinivasan

Padmanabhan

2017

The Angle Orthodontist

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“…Leptin berasal dari bahasa Yunani Leptos yang berarti kurus. 1,2 Leptin terletak pada kromosom no 7 manusia. 2 Leptin disintesis terutama oleh sel adiposa yang berfungsi sebagai regulasi berat badan, sistem hematopoetik dan remodelling tulang.…”

Section: Pendahuluanunclassified

“…1,2 Leptin terletak pada kromosom no 7 manusia. 2 Leptin disintesis terutama oleh sel adiposa yang berfungsi sebagai regulasi berat badan, sistem hematopoetik dan remodelling tulang. [1][2][3] Reseptor utama leptin berada di hipotalamus, dan berfungsi untuk menghambat asupan makanan seta meningkatkan penggunaan energi.…”

Section: Pendahuluanunclassified

“…2 Leptin disintesis terutama oleh sel adiposa yang berfungsi sebagai regulasi berat badan, sistem hematopoetik dan remodelling tulang. [1][2][3] Reseptor utama leptin berada di hipotalamus, dan berfungsi untuk menghambat asupan makanan seta meningkatkan penggunaan energi. 1,3 Kadar leptin dipengaruhi oleh jumlah lemak di dalam tubuh manusia, sehingga kadar leptin akan meningkat seiring kenaikan berat badan.…”

Section: Pendahuluanunclassified

“…[1][2][3] Reseptor utama leptin berada di hipotalamus, dan berfungsi untuk menghambat asupan makanan seta meningkatkan penggunaan energi. 1,3 Kadar leptin dipengaruhi oleh jumlah lemak di dalam tubuh manusia, sehingga kadar leptin akan meningkat seiring kenaikan berat badan. [4][5][6] Rongga mulut merupakan cerminan dari status kesehatan dan banyak perubahan yang terjadi di rongga mulut seiring peningkatan berat badan seseorang.…”

Section: Pendahuluanunclassified

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Kadar leptin saliva dan kejadian karies gigi anak obesitas (Salivary leptin levels and caries incidence in obese children)

Atzmaryanni¹,

Rizal²

2013

Dent. J. (Majalah Kedokteran Gigi)

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Leptin and its receptor expression in dental and periodontal tissues of primates

Zhu

Hou

et al. 2013

Cell Tissue Res

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Leptin and its receptor (OBR) have attracted much attention since their discovery. They have been reported to play central roles in energy balance, the immune-inflammatory response and bone metabolism. Evidence indicates that leptin and OBR are associated with inflammatory diseases of dental and periodontal tissues. The first step for establishing this is to determine the expression of leptin and OBR in these tissues. Our study is the first to examine systematically the expression of leptin and OBR in dental and periodontal tissues of monkeys (Macaca fascicularis) by immunohistochemistry and in primary cultured cells, isolated from human dental and periodontal tissues, by reverse transcription plus the polymerase chain reaction and immunocytochemistry. Our results show that leptin and OBR are constitutively expressed and widely distributed in dental and periodontal tissues of primates. Their immunoreaction is especially strong in junctional epithelium, a unique front-line defense around teeth and in mineralizing areas of the dental pulp and periodontal ligament. The expression of the long and also functional form of OBR (OBRb) indicates that leptin has a direct effect on these cells. Thus, we can reasonably infer that leptin and OBR exert effects on defense, mineralization and angiogenesis in dental and periodontal tissues of primates.

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Leptin levels in gingival crevicular fluid in periodontal health and disease

Abstract: As periodontal tissue destruction increased, there was a substantial decrease in gingival crevicular fluid leptin concentration. This observation extends our knowledge of the protective role of leptin in periodontal health.

Cited by 73 publications

References 25 publications

Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

Kadar leptin saliva dan kejadian karies gigi anak obesitas (Salivary leptin levels and caries incidence in obese children)

Leptin and its receptor expression in dental and periodontal tissues of primates

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