Leptin levels in patients with psoriasis: a meta-analysis

Abstract

Leptin levels are higher in patients with psoriasis compared with those in controls. Future studies are warranted to clarify the association between leptin levels and the pathomechanism of psoriasis.

Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies

“…Our study confirms the results of other meta-analyses that have been previously performed on the same topic [9][10][11]. Nevertheless, the novelty of the present metaanalysis consists of (i) inclusion of all 3 types of adipokines together, providing the most complete and comprehensive aspect of this key issue and (ii) analysis of more than double the number of studies compared to previous meta-analyses, making it an updated review in the field.…”

“…Recent studies suggest that adipokines, such as leptin, resistin, and adiponectin, may be implicated in the pathogenesis of psoriasis [9][10][11]. Both leptin and resistin are known to promote the production of proinflammatory mediators involved in the pathogenesis of psoriasis, such as TNF-α and CXCL8 [12].…”

Psoriasis and Obesity

“…It is speculated that a Western diet may result in an alteration of the intestinal microbiome which may then induce modulation of extraintestinal immune responses with effects on the Th17/T regulatory balance [44][45][46] . Psoriasis is characterized by proliferation of Th1, Th17, and Th22 cells resulting in the production of the pro-inflammatory mediators interferon-γ, TNF-α, IL-6, and IL-22 [12,13] . Therefore, TNF-α and IL-6 secreted by adipose tissue may contribute to the inflammatory state in psoriasis [47] .…”

Emerging role of leptin in rheumatoid arthritis

“…Normal leptin levels crucially maintain and regulate the body's immune function. Emerging evidence indicates that leptin acts as a proinflammatory cytokine in immune responses such as systemic lupus erythematosus (SLE) [3][4][5][6], RA [7][8][9][10], multiple sclerosis (MS) [11][12][13] and psoriasis [14][15][16]. Leptin could be a member of the cytokine network managing the inflammatory immune response and host defence mechanisms.…”