Leptin levels, seasonality and thermal acclimation in the Microbiotherid marsupial Dromiciops gliroides: Does photoperiod play a role?

Franco, Marcela; Contreras, Carolina; Place, Ned J.; Bozinovic, Francisco; Nespolo, Roberto F.

doi:10.1016/j.cbpa.2016.09.025

Cited by 15 publications

(15 citation statements)

References 57 publications

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“…As a consequence of increased appetite and food intake, body mass was elevated and thermogenesis increased in tree shrews. The patters are different with the Palaearctic species, as M. unguiculatus 86 , the hibernating species, as D. gliroides 28 , and the Sminthopsis crassicaudata 87 88 . This was associated with changes in other traits, including biochemical processes and hormones.…”

Section: Discussionmentioning

confidence: 99%

“…The NST capacity entirely depends on uncoupling protein 1(UCP1) in BAT, a 32-kD carrier protein located in the inner membrane of mitochondria, that separates oxidative phosphorylation from adenosine triphosphate synthesis, with energy dissipated as heat 27 . Most previous researches focused on the influence of temperature/photoperiod on physiological and biochemical properties of individuals, such as Sekeetamys calurus 20 , Lasiopodomys brandtii 21 , Meriones unguiculatus 21 , Eothenomys miletus 22 , Dromiciops gliroides 28 , Apodemus sylvaticus 29 , Acomys cahirinus 30 31 , Dipodomys ordii 32 , Dicrostonyx groenlandicus 33 , Mesocricetus auratusz 34 , Microtus agrestis 35 , and Phodopus sungorus 36 . The cytochrome c oxidase (COX, complex IV) represents the terminal enzyme of oxidative phosphorylation in mitochondria and is involved in mitochondrial energy metabolism 37 , and other biochemical acitivities associated with metabolism.…”

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confidence: 99%

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Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Lin

Yang

Wang

et al. 2017

Sci Rep

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Ambient conditions, as temperature and photoperiod, play a key role in animals' physiology and behaviors. To test the hypothesis that the maximum thermal physiological and bioenergetics tolerances are induced by extreme environments in Tupaia belangeri. We integrated the acclimatized and acclimated data in several physiological, hormonal, and biochemical markers of thermogenic capacity and bioenergetics in T. belangeri. Results showed that T. belangeri increased body mass, thermogenesis capacity, protein contents and cytochrome c oxidase (COX) activity of liver and brown adipose tissue in winter-like environments, which indicated that temperature was the primary signal for T. belangeri to regulate several physiological capacities. The associated photoperiod signal also elevated the physiological capacities. The regulations of critical physiological traits play a primary role in meeting the survival challenges of winter-like condition in T. belangeri. Together, to cope with cold, leptin may play a potential role in thermogenesis and body mass regulation, as this hormonal signal is associated with other hormones. The strategies of thermal physiology and bioenergetics differs between typical Palearctic species and the local species. However, the maximum thermal physiology and bioenergetic tolerance maybe is an important strategy to cope with winter-like condition of T. belangeri.Phenotypic plasticity is the ability of individuals to change phenotype with fluctuations in climate conditions, and responses mainly include aspects of morphology, physiology, behavior, and phenology 1 . The energy metabolism of small mammals may be the most suitable field for studying phenotypic plasticity changes 2 . The variation in physiological traits in individuals is an important response to the environment 1,3,4 . Climate conditions, including temperature and photoperiod, play a key role in seasonal variation in body mass, food intake, body fat mass, and other traits 5-9 for many species inhabiting in temperature zone, especially mammals. However, different species show different responses to climate conditions, such as Phodopus sungorus . Small mammals' response to seasonal variations such as cold or short photoperiods, by regulating physiological strategies, such as body mass and thermogenic capacity (e.g., nonshivering thermogenesis, NST) [6][7][8][12][13][14][15][16][17][18][19][20][21][22][23] . The brown adipose tissue (BAT) is a specialized organ that is involved in NST [24][25][26] , and in increased energy expenditure involves the hypothalamic-pituitary-thyroid axis and sympathetic nervous system 27 . The NST capacity entirely depends on uncoupling protein 1(UCP1) in BAT, a 32-kD carrier protein located in the inner membrane of mitochondria, that separates oxidative phosphorylation from adenosine triphosphate synthesis, with energy dissipated as heat 27

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Lin

Yang

Wang

et al. 2017

Sci Rep

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“…Dromiciops gliroides is one of the four marsupial species of Chile; it is an omnivorous, nocturnal, opossum‐like mammal with arboreal adaptations (i.e., opposable thumbs, prehensile tail and eyes in frontal plane; Hershkovitz, ). This species is strongly associated with the temperate rainforest, where temperatures fluctuate between 5 and 25°C (Franco et al., ). In this ecosystem, we captured thirteen adult D. gliroides (seven males; six females), particularly in the southern part of Valdivia, Chile (39°48′S, 73°14′W; 9 m.a.s.l.…”

Section: Methodsmentioning

confidence: 99%

“…However, a number of recent discoveries have changed this view. For instance, D. gliroides seems to anticipate the cold season as a response to photoperiodic changes and thermal acclimation (Franco, Contreras, Place, Bozinovic, & Nespolo, ). In addition, several torpor‐regulation mechanisms were described in this species, including differential expression microRNAs (Hadj‐Moussa et al., ), implementation of the stress response through MAPK signalling (Luu et al., 2018b; Wijenayake et al., 2018a), reorganization of fuel use (Wijenayake et al., 2018b) and partial suppression of protein synthesis (Luu et al., 2018a).…”

Section: Introductionmentioning

confidence: 99%

A functional transcriptomic analysis in the relict marsupial Dromiciops gliroides reveals adaptive regulation of protective functions during hibernation

et al. 2018

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The small South American marsupial, Dromiciops gliroides, known as the missing link between the American and the Australian marsupials, is one of the few South American mammals known to hibernate. Expressing both daily torpor and seasonal hibernation, this species may provide crucial information about the mechanisms and the evolutionary origins of marsupial hibernation. Here, we compared torpid and active individuals, applying high-throughput sequencing technologies (RNA-seq) to profile gene expression in three D. gliroides tissues and determine whether hibernation induces tissue-specific differential gene expression. We found 566 transcripts that were significantly up-regulated during hibernation (369 in brain, 147 in liver and 50 in skeletal muscle) and 339 that were down-regulated (225 in brain, 79 in liver and 35 in muscle). The proteins encoded by these differentially expressed genes orchestrate multiple metabolic changes during hibernation, such as inhibition of angiogenesis, prevention of muscle disuse atrophy, fuel switch from carbohydrate to lipid metabolism, protection against reactive oxygen species and repair of damaged DNA.According to the global enrichment analysis, brain cells seem to differentially regulate a complex array of biological functions (e.g., cold sensitivity, circadian perception, stress response), whereas liver and muscle cells prioritize fuel switch and heat production for rewarming. Interestingly, transcripts of thioredoxin-interacting protein (TXNIP), a potent antioxidant, were significantly over-expressed during torpor in all three tissues. These results suggest that marsupial hibernation is a controlled process where selected metabolic pathways show adaptive modulation that can help to maintain homeostasis and enhance cytoprotection in the hypometabolic state.

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“…Such behavior depends on energy requirements, locomotion, habitat productivity, body mass and sex ratio [9]. Small mammals that hibernate usually have discrete activity periods in which they face energy constraints, in response to seasonal and daily changes in environmental factors such as temperature, rainfall, photoperiods, and food availability [10]. These adverse conditions could be compensated through decreased activity and increased daily torpor under colder conditions [11,12].…”

Section: Introductionmentioning

confidence: 99%

Movement behavior of the Monito del monte (Dromiciops gliroides): new insights into the ecology of a unique marsupial

Pérez

Fontúrbel

Guevara

et al. 2019

Rev. Chil. de Hist. Nat.

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Background: Behavior and activity patterns largely determine animal's fitness and their ecological roles. Those patterns depend on many factors, being body mass, sex and age the most relevant in mammals. Particularly, those factors altogether with environmental conditions could influence movement behavior of mammals that hibernate, such as the Monito del monte (Dromiciops gliroides). Methods: To evaluate its movement behavior and activity we radio-tracked D. gliroides 12 individuals (8 females and 4 males, corresponding to 5 adults and 7 sub-adults) during the austral summer. With the estimated locations we estimated home ranges, core areas and their relationship with body mass. We also assessed movement speed during early (19:00 to 01:00 h), peak (01:00 to 03:00 h) and late (03:00 to 07:00 h) activity periods. This study was conducted at the San Martín experimental forest (Valdivia, southern Chile). Results: Estimated home range areas were 1.04 ± 0.20 ha, and core areas were 0.27 ± 0.06 ha; we found no significant differences between males and females, nor between adults and sub-adults. Home range and core areas were independent of body mass in females but showed positive relationships in males. Core area overlap was larger between sub-adult and adult individuals (35%) than between adult males and females (13%). Average movement D. gliroides speed was 1.45 m/min, reaching its lowest value during the peak activity period (01:00 to 03:00 h), but being faster during early and late activity periods. Those speed differences may be related to travelling and foraging activities. Conclusion: Home range and core areas estimated here showed a large variability, which can be related to environmental factors. Home range size was positively correlated with body mass on males but not on females. Also, lower movement speeds at the peak activity period suggest that D. gliroides concentrates feeding activities at this time. As D. gliroides disperses the seeds of at least 16 native plant species, its movement behavior also has important consequences at the community level.

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Leptin levels, seasonality and thermal acclimation in the Microbiotherid marsupial Dromiciops gliroides: Does photoperiod play a role?

Cited by 15 publications

References 57 publications

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

A functional transcriptomic analysis in the relict marsupial Dromiciops gliroides reveals adaptive regulation of protective functions during hibernation

Movement behavior of the Monito del monte (Dromiciops gliroides): new insights into the ecology of a unique marsupial

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