Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity

Gil-Cosano, José J.; Gracia‐Marco, Luis; Ubago‐Guisado, Esther; Migueles, Jairo H; Courteix, Daniel; Labayen, Idoia; Plaza‐Florido, Abel; Molina-García, Pablo; Dutheil, Frédéric; Ortega, Francisco B.

doi:10.1111/apa.16456

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…In fact, bone accrual in children who are overweight or obese is affected by different humoural stimuli such as inflammatory cytokines, myokines and adipokines including leptin [ 40 ]. An article by Gil-Cosano et al [ 41 ] showed that leptin levels were negatively correlated with lumbar spine BMC in overweight or obese children, but a high MF at the lower body could counteract this association, as those children whose maximal repetition at leg press test was above 133.3 kg could overcome the negative influence of leptin. This means a positive effect of MF on bone health, in agreement with the outcomes shown in the present study.…”

Section: Discussionmentioning

confidence: 99%

High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity

Comeras-Chueca,

Villalba-Heredia,

Lozano-Berges

et al. 2024

Arch Osteoporos

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Summary Muscular fitness plays a major role in bone health and body composition in overweight and obese children. It is key that the development of this muscle fitness is affected by absolute isometric strength and dynamic strength. Purpose To compare bone health and body composition between overweight/obese children considering muscular fitness (MF) levels, and to investigate whether weight-bearing dynamic or absolute isometric strength, both involved in the development of this muscular fitness, are more related with bone health. Methods MF of 59 overweight or obese children (10.1 ± 0.9 years, 27 females) was measured by a countermovement jump (CMJ), handgrip, and maximal isometric strength of knee extension. Participants were divided into four groups depending on their MF level performing a cluster analysis: 16 children with high MF (HMF) in all tests, 18 with high performance in isometric strength (HIS), 15 with high performance in CMJ (HCMJ) and 10 low isometric and low dynamic force values (LMF). Body composition values were measured by dual energy X-ray absorptiometry, and bone strength values were assessed by peripheral quantitative computed tomography. Motor skills were evaluated using TGMD-3. Multivariate analysis of covariance test was applied to analyse bone strength differences between children in the different MF groups, using maturity offset, height and weight as covariates, and correlations were investigated. Results HMF excelled in bone health. HIS had higher cortical bone area, periosteal circumference, bone mass, polar strength strain index and fracture load than LMF, while HCMJ only showed better results in trabecular bone area than LMF. HMF had significantly better values of fracture load and periosteal and endosteal circumferences than HCMJ, but not than HIS. Conclusions High MF level shows positive effects on bone health in overweight/obese children. Those with highest isometric strength had better bone health compared to those with higher dynamic strength. Trial registration The research project was registered in a public database Clinicaltrials.gov in June 2020 with the identification number NCT04418713.

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Section: Discussionmentioning

confidence: 99%

High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity

Comeras-Chueca,

Villalba-Heredia,

Lozano-Berges

et al. 2024

Arch Osteoporos

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Dietary content and combined training, but not daily physical activity, are associated with 6-month bone mineral changes in adolescents with obesity: A Secondary analysis of the PAC-MAnO trial

Videira-Silva,

Santos,

Freaza

et al. 2024

Eur J Pediatr

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Purpose The present study aimed to explore the influence of diet and physical activity (PA) changes on bone mineral content (BMC) and density (BMD) alterations in adolescents with obesity undergoing a weight loss program. Methods Six-month longitudinal data from 71 adolescents (aged 15.1 [± 1.6] years; 57.7% girls) with a BMI z-score of 3.03 (± 0.78), previously recruited for the PAC-MAnO trial, were analyzed using Generalized Estimation Equations for over time changes and linear regressions with BMC, BMD and BMD z-score as dependent variables, adjusting for confounders (including type of exercise- aerobic vs. combined). Results Adjusting for confounders, changes in carbohydrate (CH) and protein content showed to positively and negatively predict BMD z-score variance, respectively (β = 0.44, 95%CI: 0.01, 0.04, p < .001); β = -0.57, 95%CI: -0.06, -0.03, p < .001), yet no associations were found between PA and bone-related parameters. Combined exercise showed better results on BMC compared to aerobic exercise (β = 0.09, 95%CI: 0.05 to 0.13, p < .001). Conclusions Increased CH content, instead of protein, may be associated with BMD improvements in adolescents with obesity. Type of exercise may moderate the impact of PA on bone health. Trial registration Clinicaltrials.gov NCT02941770. What is Known• Adolescents with obesity may be at a higher risk of osteopenia/osteoporosis• Obesity and inadequate diet and physical activity (PA) may have an adverse effect on bone metabolism What is New• Improvements in adiposity and muscle mass and increased diet carbohydrate content are associated with bone mineral density (BMD) improvements• Type of exercise (i.e., combined training vs. aerobic) may moderate the impact of PA on BMD, and calcium intake may mediate this impact

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Sex-specific effects of a Mediterranean diet on lower limb bone strength in Polish children

Masztalerz-Kozubek,

Zielinska-Pukos,

Hamulka

2024

Bone

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Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity

Cited by 5 publications

References 32 publications

High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity

High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity

Dietary content and combined training, but not daily physical activity, are associated with 6-month bone mineral changes in adolescents with obesity: A Secondary analysis of the PAC-MAnO trial

Sex-specific effects of a Mediterranean diet on lower limb bone strength in Polish children

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