Leptin modulates the response to oleic acid in the pharynx

Kitagawa, Junichi; Shingai, Tomio; Kajii, Yuka; Takahashi, Yoshihiro; Taguchi, Yoshinari; Matsumoto, Shigeji

doi:10.1016/j.neulet.2007.06.040

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…However, some experiments have shown that part of this adaptation may also occur at the level of the peripheral sensory system. This holds particularly true for taste organs and has been well described in invertebrates (45) and in rodents where leptin modulates responses to sugars and fatty acids (46, 47). In the olfactory system, neuropeptide Y and endocannabinoids modulate ORNs activity respectively in axolotls (48) and in xenopus (49).…”

Section: Discussionmentioning

confidence: 97%

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

Lacroix

Badonnel

Meunier

et al. 2008

J Neuroendocrinology

114

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Food odours are major determinants for food choice; their detection is influenced by nutritional status. Among different metabolic signals, insulin plays a major role in food intake regulation. The aim of the present study was to investigate a potential role of insulin in the olfactory mucosa (OM), using ex vivo tissues and in vitro primary cultures. We first established the expression of insulin receptor (IR) in rat olfactory mucosa. Transcripts of IR-A and IR-B isoforms, as well as IRS-1 and IRS-2, were detected in OM extracts. Using immunocytochemistry, IR protein was located in olfactory receptor neurones, sustentacular and basal cells and in endothelium of the lamina propria vessels. Moreover, the insulin binding capacity of OM was quite high compared to that of olfactory bulb or liver. Besides the main pancreatic insulin source, we demonstrated insulin synthesis at a low level in the OM. Interestingly 48 h of fasting, leading to a decreased plasmatic insulin, increased the number of IR in the OM. Local insulin concentration was also enhanced. These data suggest a control of OM insulin system by nutritional status. Finally, an application of insulin on OM, aiming to mimic postprandial insulin increase, reversibly decreased the amplitude of electro-olfactogramme responses to odorants by approximately 30%. These data provide the first evidence that insulin modulates the most peripheral step of odour detection at the olfactory mucosa level.

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Section: Discussionmentioning

confidence: 97%

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

Lacroix

Badonnel

Meunier

et al. 2008

J Neuroendocrinology

114

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show abstract

“…In addition, lingual lipase is secreted from von Ebner's glands (15,38), which also are located in the posterior oral cavity. In this regard, the FFA oleic acid is reported to activate the GL (33), although in that study, recordings were from the pharyngeal branch of the GL, which innervates receptors in the pharynx that are important in the control of reflexes (33). Nonetheless, bilateral transection of the GL impairs the ability of mice to discriminate LA from a control solution (20), which provides additional support for GL involvement in FFA taste processing.…”

Section: Taste Preferencesmentioning

confidence: 88%

“…Unlike the traditional two-bottle preference test in which a preference score of ϳ0.5 indicates an indifference to a test solutions, a preference score of ϳ0. 33 indicates an indifference between test solutions, and a preference score Ͼ0.33 indicates a preference for a test solution; a preference score Ͻ0. 33 indicates an aversion to a test solution.…”

Section: Experiments 2: Msg and La Taste Preferencesmentioning

confidence: 99%

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Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats

Stratford

Curtis²,

Contreras³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Previous studies suggest that the chorda tympani nerve (CT) is important in transmitting fat taste information to the central nervous system. However, the contribution of the CT in this process may depend upon the presence of other taste stimuli and/or differ in males and females. Accordingly, the present study investigated the role of the CT in free fatty acid taste processing by examining electrophysiological activity of the CT in response to the free fatty acid linoleic acid (LA), as well as by measuring behavioral responses to LA-taste mixtures. We recorded whole nerve responses from the CT in response to lingual application of LA with or without monosodium glutamate (MSG) in anesthetized male and female rats. In addition, we examined preferences for MSG + LA taste mixtures in behavioral tests. Although lingual application of LA alone did not produce CT whole nerve responses, coapplication of LA and MSG elicited greater CT responses than did MSG alone. These findings were paralleled by greater preferences for MSG + LA taste mixtures than for MSG alone. In both cases, the effect was particularly pronounced in male rats. Thus LA enhances CT activity and behavioral responses to LA + MSG taste mixtures, although there are sex differences in the effects. These results suggest that CT input is important in mediating behavioral responses to fat taste, but the effects depend upon other taste stimuli and differ in males and females.

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Chemical Senses

Travers¹,

Travers²

2009

Handbook of Neuroscience for the Behavioral Sciences

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Leptin modulates the response to oleic acid in the pharynx

Cited by 7 publications

References 22 publications

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats

Chemical Senses

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