2023
DOI: 10.1111/ijpo.13072
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Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker

Agustina Malpeli,
María Victoria Fasano,
Marisa Sala
et al.

Abstract: SummaryBackgroundMolecular biomarkers of maternal leptin resistance associated with infant weight are needed.ObjectivesTo evaluate gene expression of leptin receptor (LEPR), suppressor of cytokine signalling 3 (SOCS3) and insulin receptor in peripheral blood mononuclear cells (PBMCs) of lactating women and their relationship with infant body weight and adiposity.MethodsAt day 10 postpartum, maternal gene expression in PBMCs as well as leptin and insulin concentrations in plasma and milk were assessed (n = 68).… Show more

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