Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action

Laque, Amanda; Zhang, Yan; Gettys, Sarah; Nguyễn, Thủy Thu; Bui, Kelly; Morrison, Christopher D.; Münzberg, Heike

doi:10.1152/ajpendo.00643.2012

Cited by 83 publications

(94 citation statements)

References 62 publications

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“…(For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) known to show specific distributions in the DMH, PF and LH, i.e., those regions in which postnatal NPW neurons were observed in the present study (Leinninger et al, 2011;Laque et al, 2013). Currently, any co-localization of these neurotransmitters with NPW remains unknown and further studies will be required to elucidate the function(s) of these postnatal NPW neurons.…”

Section: Discussionmentioning

confidence: 64%

Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis

et al. 2015

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Neuropeptide B and W (NPB and NPW) are cognate peptide ligands for NPBWR1 (GPR7), a G protein-coupled receptor. In rodents, they have been implicated in the regulation of energy homeostasis, neuroendocrine/autonomic responses, and social interactions. Although localization of these peptides and their receptors in adult rodent brain has been well documented, their expression in mouse brain during development is unknown. Here we demonstrate the transient expression of NPW mRNA in the dorsomedial hypothalamus (DMH) of postnatal mouse brain and its co-localization with neuropeptide Y (NPY) mRNA. Neurons expressing both NPW and NPY mRNAs begin to emerge in the DMH at about postnatal day 0 (P-0) through P-3. Their expression is highest around P-14, declines after P-21, and by P-28 only a faint expression of NPW and NPY mRNA remains. In P-18 brains, we detected NPW neurons in the region spanning the subincertal nucleus (SubI), the lateral hypothalamic (LH) perifornical (PF) areas, and the DMH, where the highest expression of NPW mRNA was observed. The majority of these postnatal hypothalamic NPW neurons co-express NPY mRNA. A cross of NPW-iCre knock-in mice with a Cre-dependent tdTomato reporter line revealed that more than half of the reporter-positive neurons in the adult DMH, which mature from the transiently NPW-expressing neurons, are sensitive to peripherally administrated leptin. These data suggest that the DMH neurons that transiently co-express NPW and NPY in the peri-weaning period might play a role in regulating energy homeostasis during postnatal development.

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Section: Discussionmentioning

confidence: 64%

Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis

et al. 2015

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“…2), suggesting that numerous LHA neuronal subpopulations synthesize the excitatory neurotransmitter, glutamate. In addition to glutamate, the LHA is enriched with GABAergic neuronal markers 82,84,86,87 (Fig. 2), which are largely segregated from Vglut2-expressing LHA cells 85 .…”

Section: Molecular Phenotypes and Functions Of Lha Neuronsmentioning

confidence: 99%

Lateral hypothalamic circuits for feeding and reward

2016

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In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in non-restricted animals. In the absence of food, animals will work tirelessly, often lever-pressing 1000’s of times per hour, for electrical stimulation at the same site that provokes feeding, drinking, and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has utilized contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala, and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding specific circuits.

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“…3). Importantly, these structures contain neurons that express considerable levels of leptin receptors 139–141 .…”

Section: Leptin and Neural Control Of Adiposementioning

confidence: 99%

Leptin and brain–adipose crosstalks

et al. 2018

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Interactions between the brain and distinct adipose depots have a key role in maintaining energy balance, thereby promoting survival in response to metabolic challenges such as cold exposure and starvation. Recently, there has been renewed interest in the specific central neuronal circuits that regulate adipose depots. Here, we review anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion. In particular, we emphasize the role of leptin-sensitive neurons and the sympathetic nervous system in modulating the activity of brown, white and beige adipose tissues. We provide an overview of advances in the understanding of the heterogeneity of the brain regulation of adipose tissues and offer a perspective on the challenges and paradoxes that the community is facing regarding the actions of leptin on this system.

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Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action

Abstract: receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action.

Cited by 83 publications

References 62 publications

Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis

Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis

Lateral hypothalamic circuits for feeding and reward

Leptin and brain–adipose crosstalks

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