2021
DOI: 10.3390/nu13051544
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Leptin Receptors Are Not Required for Roux-en-Y Gastric Bypass Surgery to Normalize Energy and Glucose Homeostasis in Rats

Abstract: Sensitization to the adipokine leptin is a promising therapeutic strategy against obesity and its comorbidities and has been proposed to contribute to the lasting metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We formally tested this idea using Zucker fatty fa/fa rats as an established genetic model of obesity, glucose intolerance, and fatty liver due to leptin receptor deficiency. We show that the changes in body weight in these rats following RYGB largely overlaps with that of diet-induced ob… Show more

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Cited by 2 publications
(2 citation statements)
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“…The reasoning for this is that a large number of studies solely evaluating leptin were retrieved and could, by themselves, be studied in a future meta-analysis. Because leptin signaling does not appear to be necessary for appetite suppression and weight loss after RYGB, 25,32,33 members of the research group decided not to have leptin as a main outcome in this paper. If data from multiple reports corresponded to the same study, only the study with the most information of the outcomes of interest was included.…”
Section: Eligibility Criteriamentioning
confidence: 99%
“…The reasoning for this is that a large number of studies solely evaluating leptin were retrieved and could, by themselves, be studied in a future meta-analysis. Because leptin signaling does not appear to be necessary for appetite suppression and weight loss after RYGB, 25,32,33 members of the research group decided not to have leptin as a main outcome in this paper. If data from multiple reports corresponded to the same study, only the study with the most information of the outcomes of interest was included.…”
Section: Eligibility Criteriamentioning
confidence: 99%
“…Hankir et al [1] revisited the premise that enhanced central leptin sensitivity contributes to the beneficial effects of RYGB on body weight status, glycemic control, and liver health. The researchers performed RYGB on Zucker fatty rats that developed overweight and obesity, glucose intolerance and fatty liver disease from functional mutation loss in the leptin receptor gene and diet-induced obese rats with intact leptin receptors.…”
mentioning
confidence: 99%