Leptin receptors

Górska, Elżbieta; Popko, Katarzyna; Stelmaszczyk-Emmel, Anna; Ciepiela, Olga; Kucharská, Anna; Wasik, M

doi:10.1186/2047-783x-15-s2-50

Cited by 153 publications

(92 citation statements)

References 39 publications

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“…The long active leptin receptor isoform is primarily expressed in the hypothalamus including nuclei involved in the regulation of energy balance (47,48). This location places leptin in position to communicate energy balance but also to influence hypothalamus-pituitary-endocrine organ axes (49).…”

Section: Leptin -Regulation Of Neuroendocrine Axismentioning

confidence: 99%

GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans

Papathanasiou

Nolen‐Doerr

Farr

et al. 2019

European Journal of Endocrinology

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The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine system that regulates appetite and body weight. Fluctuating leptin levels provide molecular signals to the brain regarding available energy reserves modulating energy homeostasis and neuroendocrine response in states of leptin deficiency and to a lesser extent in hyperleptinemic states. While leptin replacement therapy fails to provide substantial benefit in common obesity, it is an effective treatment for congenital leptin deficiency and states of acquired leptin deficiency such as lipodystrophy. Current evidence suggests that regulation of eating behavior in humans is not limited to homeostatic mechanisms and that the reward, attention, memory and emotion systems are involved, participating in a complex central nervous system network. It is critical to study these systems for the treatment of typical obesity. Although progress has been made, further studies are required to unravel the physiology, pathophysiology and neurobehavioral mechanisms underlying potential treatments for weight-related problems in humans.

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Section: Leptin -Regulation Of Neuroendocrine Axismentioning

confidence: 99%

GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans

Papathanasiou

Nolen‐Doerr

Farr

et al. 2019

European Journal of Endocrinology

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show abstract

“…Leptin acts through the leptin receptor (Ob-R), encoded by the db gene [22]. Ob-R is a member of the class I cytokine receptor family and it is composed for six different isoforms, all of them products of the alternative splicing of the Ob-R mRNA [23]. Leptin and Ob-R are expressed in many other tissues, like the placenta and lungs [24,25].…”

Section: Leptinmentioning

confidence: 99%

Perinatal Undernutrition, Metabolic Hormones, and Lung Development

et al. 2019

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Maternal and perinatal undernutrition affects the lung development of litters and it may produce long-lasting alterations in respiratory health. This can be demonstrated using animal models and epidemiological studies. During pregnancy, maternal diet controls lung development by direct and indirect mechanisms. For sure, food intake and caloric restriction directly influence the whole body maturation and the lung. In addition, the maternal food intake during pregnancy controls mother, placenta, and fetal endocrine systems that regulate nutrient uptake and distribution to the fetus and pulmonary tissue development. There are several hormones involved in metabolic regulations, which may play an essential role in lung development during pregnancy. This review focuses on the effect of metabolic hormones in lung development and in how undernutrition alters the hormonal environment during pregnancy to disrupt normal lung maturation. We explore the role of GLP-1, ghrelin, and leptin, and also retinoids and cholecalciferol as hormones synthetized from diet precursors. Finally, we also address how metabolic hormones altered during pregnancy may affect lung pathophysiology in the adulthood.

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“…The leptin receptor [LEPR, also referred to as the obesity receptor (Ob-R)] is a single membrane-spanning receptor with six isoforms (Ob-Ra, b, c, d, e and f) resulting from alternative RNA splicing [48]. However, only full-length Ob-Rb can transduce signals into cells.…”

Section: Indirect Actions Of Bpa In the Ovary Through Adipokinesmentioning

confidence: 99%

The Ovary as a Target Organ for Bisphenol A Toxicity

Ptak¹,

Hoffmann²,

Rak³

2017

Bisphenol a Exposure and Health Risks

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The ovary is a hormone-sensitive organ that produces steroid hormones. Recent studies show that bisphenol A (BPA) can affect female reproduction; thus, it is important to identify the possible toxic effects of BPA on the ovary because this organ is indispensable for fertility. This chapter summarises the effects of BPA on the ovary by describing how they directly affect folliculogenesis, steroidogenesis and receptor signalling and how they indirectly affect the expression of adipokines and/or their receptors, which exert endocrine or autocrine functions within the ovary.

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Leptin receptors

Cited by 153 publications

References 39 publications

GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans

GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans

Perinatal Undernutrition, Metabolic Hormones, and Lung Development

The Ovary as a Target Organ for Bisphenol A Toxicity

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