Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma

Verbovoy, A.F. Verbovoy; Косарева, О. В.; Akhmerova, R. I.

doi:10.17116/terarkh2015871037-41

Cited by 5 publications

(9 citation statements)

References 2 publications

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“…All eighteen articles selected described the association between asthma and T2DM. Seven studies advocated low-grade systemic inflammation as a mechanism that associates asthma and T2DM [ 14 – 16 , 19 , 28 , 30 – 31 ], 7 studies the use of medications as factors that associate asthma with DM2 [ 19 , 23 , 27 , 32 – 34 ], and 5 studies addressed the impact of the association between asthma and T2DM for asthma control [ 20 , 21 , 37 – 40 ]. One study had data available for low-grade systemic inflammation and medication use as mechanisms that associate asthma with T2DM; thus this article was included in both subanalyses [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…From the review of the selected articles ( Table 1 ), it was possible to observe that asthma and T2DM are two common chronic conditions of increasing prevalence [ 1 , 9 ] and that frequently coexist in the same patient [ 14 , 15 , 28 ]. It is hypothesized that low-grade systemic inflammation [ 14 – 16 , 19 , 28 , 30 , 31 ] and the use of medications, particularly corticosteroids [ 19 , 23 , 27 , 29 , 32 – 34 ], may be the cause of this association. Hyperglycemia and hyperinsulinemia in the lungs also appear to contribute to reduced lung function and a higher occurrence of asthma in patients with diabetes [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…In seven studies, the mechanisms explaining the association between asthma and T2DM were presented, from the perspective of low-grade systemic inflammation [ 14 – 16 , 19 , 28 , 30 , 31 ]. Scientific evidence proves that asthma [ 40 ] and T2DM [ 14 , 41 , 42 ] are associated with low-grade systemic inflammation, dependent or independent of obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is a chronic condition that leads to systemic inflammation and, when present, has been identified as the main explanation for the association between asthma and T2DM. However, although excess body fat and airway inflammation in asthma can interact to promote the development of diabetes [ 14 , 31 ], it also shares the common inflammatory bases with T2DM, regardless of the increase in BMI [ 15 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, adiponectin reduces the lipid storage capacity of adipocytes, inhibits liver neoglucogenesis, and increases the sensitivity of cells to the action of insulin [ 22 , 44 ]. Hyperleptinemia, hyperresistinemia, and lower concentrations of adiponectin, as well as elevated levels of IL-6 and reduced levels of IL-10, were found in patients with T2DM and in those with concomitant T2DM and asthma [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Association between Asthma and Type 2 Diabetes Mellitus: Mechanisms and Impact on Asthma Control—A Literature Review

Torres

Souza

Coelho

et al. 2021

Canadian Respiratory Journal

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The study aimed to analyze the scientific production on the association between asthma and type 2 diabetes mellitus (T2DM) in adults, the mechanisms that explain this association, and its impact on asthma control. A literature review of scientific articles indexed in the MEDLINE/PUBMED, BVS, CINAHL, Cochrane Library, and Web of Science databases was carried out, considering publications from January 2009 to December 2019, using the following descriptors: “asthma”, “type 2 diabetes”, “adult,” and “association”. Of 962 articles found, 18 were included because they met the eligibility criteria. It is suggested that the association between asthma and T2DM is caused by low-grade systemic inflammation (7 articles) or the use of corticosteroids (7 articles). It is noticed that there is a limited scientific production regarding the consequences of this association for the control of asthma (5 articles). It is concluded that asthma and T2DM are two common chronic conditions of increasing prevalence and that often coexist in the same patient. It is suggested that this coexistence worsens asthma control. Therefore, the study may support public policies and clinical health practices that value the approach of comorbidities associated with asthma such as T2DM, in order to minimize additional health risks and reduce the quality of life.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Association between Asthma and Type 2 Diabetes Mellitus: Mechanisms and Impact on Asthma Control—A Literature Review

Torres

Souza

Coelho

et al. 2021

Canadian Respiratory Journal

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Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies

Ray

2018

WJCC

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Obesity is an important risk factor for postmenopausal breast cancer and also a poor prognostic factor among cancer patients. Moreover, obesity is associated with a number of health disorders such as insulin resistance/type-2 diabetes mellitus, hypertension, and other cardiovascular diseases. Frequently, these health disorders exhibit as components/complications of the metabolic syndrome. Nevertheless, obesity-related diseases may coexist with postmenopausal breast cancer; and these comorbid conditions could be substantial. Therefore, it may be assumed that different diseases including breast cancer could originate from a common pathological background in excessive adipose tissue. Adipocyte-released hormone-like cytokine (or adipokine) leptin behaves differently in a normal healthy state and obesity. A growing body of evidence suggests an important role of leptin in our major obesity-related health issues such as insulin resistance, hypertension, and neoplasia. In this context, this review describes the relationships of the abovementioned pathologies with leptin.

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The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2021

Terapevticheskii arkhiv

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The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.

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Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma

Cited by 5 publications

References 2 publications

Association between Asthma and Type 2 Diabetes Mellitus: Mechanisms and Impact on Asthma Control—A Literature Review

Association between Asthma and Type 2 Diabetes Mellitus: Mechanisms and Impact on Asthma Control—A Literature Review

Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

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