Leptin responses to insulin administration in children with short stature

Zotter, Heinz; Kerbl, Reinhold; Gallistl, Siegfried; Aigner, Reingard; Pichler, Gerhard; Borkenstein, Martin

doi:10.1016/j.metabol.2005.01.032

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…In this respect, an inverse correlation has been reported between leptin and GH in NS children as well as in subjects with GH deficiency . Conversely, in other studies, relatively lower concentrations of leptin have been found in children with GH deficiency and ISS . In the present study, leptin concentrations increased significantly in NS children but tended to reduce in ISS children after stimulation.…”

Section: Discussionsupporting

confidence: 46%

Idiopathic short stature and growth hormone sensitivity in prepubertal children

Derraik

Miles

Hofman

et al. 2019

Clinical Endocrinology

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Objective:We compared growth hormone sensitivity to an insulin-like growth factor I (IGF-I) generation test in children with idiopathic short stature (ISS) and of normal stature (NS) across the birthweight range.Methods: Forty-six prepubertal children (~7.1 years) born at term were studied: ISS (n = 23; 74% boys) and NS (n = 23; 57% boys). Children underwent a modified IGF-I generation test with recombinant human growth hormone (rhGH; 0.05 mg/kg/d) over four consecutive days. Hormonal concentrations were measured at baseline and day 5.Results: Children with idiopathic short stature were 1.90 SDS lighter (P < 0.0001) but had 4.5% more body fat (P = 0.0007) than NS children. Overall, decreasing birthweight SDS across the normal range (−1.9 to +1.5 SDS) was associated with lower percentage IGF-I response to rhGH stimulation in univariable (r = 0.45; P = 0.002) and multivariable models (β = 24.6; P = 0.006). Plasma IGF-I concentrations rose in both groups with rhGH stimulation (P < 0.0001). GHBP levels (P = 0.002) were suppressed in ISS children (−19%; P = 0.029) but increased among NS children (+18%; P = 0.028), with contrasting responses also observed for leptin and IGFBP-1. Further, the increase in insulin concentrations in response to rhGH stimulation was ~3-fold greater in NS children (142% vs 50%; P = 0.006). Conclusions:A progressive decrease in birthweight SDS was associated with a reduction in GH sensitivity in both NS and ISS children. Thus, the lower IGF-I response to rhGH stimulation in association with decreasing birthweight indicates that the ISS children at the lower end of the birthweight spectrum may have partial GH resistance, which may contribute to their poorer growth. K E Y W O R D S growth hormone binding globulin, height, insulin-like growth factor I, recombinant human growth hormone, sensitivity 1 | INTRODUC TI ON Idiopathic short stature (ISS) represents a heterogeneous disorder, which accounts for approximately 80% of children with short stature. 1 According to Ranke et al, 2 ISS is defined by a height more than two standard deviation scores (SDS) below the corresponding mean height for age, sex and ethnicity in a child with normal or slow height velocity, normal birthweight and absence | 111 DERRAIK Et Al. S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Derraik JGB, Miles HL, Chiavaroli V, Hofman PL, Cutfield WS. Idiopathic short stature and growth hormone sensitivity in prepubertal children. Clin Endocrinol

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Section: Discussionsupporting

confidence: 46%

Idiopathic short stature and growth hormone sensitivity in prepubertal children

Derraik

Miles

Hofman

et al. 2019

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Therefore, it is possible that leptin may participate in GHD pathogenesis. Recent studies have identified significantly suppressed serum leptin levels in GHD patients, showing significant correlations with IGF-1 levels [ 11 – 14 ], further supporting the role of lower leptin levels in GHD. A genetic study found possible involvement of leptin and leptin receptor gene polymorphism in regulating leptin secretion level [ 15 ].…”

Section: Introductionmentioning

confidence: 89%

The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency

Fang

Lin

et al. 2016

Med Sci Monit

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BackgroundsGrowth hormone deficiency (GHD) is a major cause of congenital short stature. GHD patients have significantly decreased serum leptin levels, which are regulated by gene polymorphism of leptin and leptin receptor. This study thus investigated the relationship between gene polymorphism and susceptibility to GHD.Material/MethodsA case-control study was performed using 180 GHD children in addition to 160 healthy controls. After the extraction of whole genomic DNA, the genotypes of leptin and leptin receptor gene loci were analyzed by sequencing for single-nucleotide polymorphism.ResultsThe frequency distribution of all alleles identified in leptin gene (loci rs7799039) and leptin receptor gene (loci rs1137100 and rs1137101) fit Hardy-Weinberg equilibrium. There was a significant difference in allele frequency at loci rs7799039 or rs1137101, as individuals with heterozygous GA allele had lower (rs7799039) or higher (rs1137101) GHD risk. No significant difference in allele frequency was discovered at loci rs1137100 (p>0.05), which was unrelated to GHD susceptibility.ConclusionsGene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with GHD susceptibility.

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Study of the leptin levels and its gene polymorphisms in patients with idiopathic short stature and growth hormone deficiency

Yang

et al. 2012

Endocrine

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Leptin levels may regulate fat metabolism, skeletal growth, and puberty. Leptin gene variants affect risk of obesity, cancer, but their effect on onset of growth hormone deficiency (GHD) and idiopathic short stature (ISS) is unknown. We tested the hypothesis that the phenotype of GHD and ISS may be associated with polymorphism in the leptin gene. The prevalence of a single nucleotide polymorphism (SNP) in the leptin gene (LEP) promoter at -2548 and the leptin and insulin growth factor-1 (IGF-1) concentrations in GHD and ISS were compared to those of healthy controls. IGF-1 and leptin concentrations were significantly lower in both the GHD and ISS groups than in the control group. The ISS and GHD groups had a significantly different distribution of SNP alleles at the LEP -2548 (P = 0.010). Individuals with LEP -2548A/G or G/G genotype in ISS group (47.5%) showed a significantly lower weight and body mass index (BMI) (but not leptin levels) than individuals carrying the A/A genotype (52.5%). LEP -2548A/A in GHD patients (65.8%) was associated with lower weight, BMI, leptin concentrations than those of individuals carrying the A/G or G/G genotype (34.2%). These data suggest that the LEP -2548A polymorphism may associate with the weight and BMI of the children with ISS and GHD.

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Leptin responses to insulin administration in children with short stature

Cited by 5 publications

References 37 publications

Idiopathic short stature and growth hormone sensitivity in prepubertal children

Idiopathic short stature and growth hormone sensitivity in prepubertal children

The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency

Study of the leptin levels and its gene polymorphisms in patients with idiopathic short stature and growth hormone deficiency

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