Leptin, Soluble Leptin Receptors, Free Leptin Index, and Their Relationship with Insulin Resistance and BMI: High Normal BMI is the Threshold for Serum Leptin Increase in Humans

Owecki, Maciej; Nikisch, Elzbieta; Miczke, Anna; Pupek-Musialik, Danuta; Sowiński, Jerzy

doi:10.1055/s-0030-1253422

Cited by 40 publications

(48 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data also did not support the role of FLI, which is considered to better reflect leptin activity (43,44). These results are in contrast to the evidence from 2 previous prospective studies, which reported that leptin is associated to risk of CRC independently of BMI.…”

Section: Discussioncontrasting

confidence: 99%

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

et al. 2012

View full text Add to dashboard Cite

Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P trend ¼ 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P trend ¼ 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P trend ¼ 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P trend ¼ 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328-37. Ó2012 AACR.

show abstract

Section: Discussioncontrasting

confidence: 99%

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The FLI has been developed and suggested as a marker of the presumed free leptin concentrations [19,20,29]. Not surprisingly, FLI exhibited tracking, as did its constituents, leptin and SLR.…”

Section: Discussionmentioning

confidence: 99%

Tracking of Leptin, Soluble Leptin Receptor, and the Free Leptin Index during Weight Loss and Regain in Children

Holm¹,

Gamborg²,

Ward³

et al. 2011

Obes Facts

View full text Add to dashboard Cite

Objective: To investigate changes in leptin and soluble leptin receptor (SLR) concentrations, and in the free leptin index (FLI) during weight loss and subsequent weight regain; and to ascertain whether these indices remain stable in the rank of the distribution in repeated measures (tracking) during perturbations of weight in obese children. Design and Measurements: In a longitudinal study, 115 obese children were examined during a 12- week weight loss programme and 28 months of follow-up. Height, weight, body composition, Tanner stages, testicular size, time of menarche, and concentrations of leptin and SLR were measured at baseline, on days 14, 33, and 82, and from months 10, 16, and 28. Results: During weight loss, leptin decreased and the SLR increased. During weight regain, leptin increased and the SLR decreased. The partial correlation coefficients expressing the relationship between leptin and SLR were significant in girls during both weight loss and weight regain, whereas in boys they were much weaker and not significant. Leptin, SLR and FLI exhibited individual-specific levels (tracking) during weight loss and regain in boys and girls. The observed tracking seemed stronger during weight loss than during weight regain. The observed tracking was independent of both baseline body mass index (BMI) standard deviation score (SDS) and pubertal development at baseline and of subsequent changes in BMI SDS and puberty stages. Conclusion: Leptin and the SLR exhibit tracking during weight loss and regain, which indicates individual stability in the leptin system despite challenges of weight.

show abstract

“…Circulating levels of leptin, an adipocyte-derived adipokine that classically plays a crucial role in regulating appetite and energy balance, are strongly correlated with body fat content and markedly elevated in obese individuals (2, 3) as well as in breast, ovarian, and endometrial cancer patients (4, 5). The women’s health initiative studies have identified obesity as a major breast cancer risk factor for postmenopausal women who had never taken hormone replacement therapy (6).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA

et al. 2014

View full text Add to dashboard Cite

Obesity is a pandemic and major risk factor for cancers. The reduction of obesity would have been an effective strategy for cancer prevention, but the reality is that worldwide obesity has kept increasing for decades, remaining a major avoidable cancer risk secondary only to smoke. The present studies suggest that vitamin D may be an effective agent to reduce obesity-associated cancer risks in women. Molecular analyses showed that leptin increased human telomerase reverse transcriptase (hTERT) mRNA expression and cell growth through estrogen receptor alpha (ERα) activation in ovarian cancer (OCa) cells, which was suppressed by 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. The suppression was compromised when miR-498 induction by the hormone was depleted with miRNA sponges. In mice, high-fat diet (HFD) stimulation of ovarian tumor growth was remarkably suppressed by 1,25(OH)2D3 analogue EB1089, which was also compromised by miR-498 sponges. EB1089 did not alter HFD-induced increase in serum leptin levels but increased miR-498 and decreased the diet-induced hTERT expression in tumors. Quantitative RT-PCR (qRT-PCR) analyses revealed an inverse correlation between hTERT mRNA and miR-498 in response to 1,25(OH)2D3 in estrogen-sensitive ovarian, endometrial and breast cancers. The studies suggest that miR-498-mediated hTERT down regulation is a key event mediating the anti-leptin activity of 1,25(OH)2D3 in estrogen-sensitive tumors in women.

show abstract

Leptin, Soluble Leptin Receptors, Free Leptin Index, and Their Relationship with Insulin Resistance and BMI: High Normal BMI is the Threshold for Serum Leptin Increase in Humans

Cited by 40 publications

References 16 publications

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Tracking of Leptin, Soluble Leptin Receptor, and the Free Leptin Index during Weight Loss and Regain in Children

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA

Contact Info

Product

Resources

About