Leptin suppresses development of GLP-1 Inputs to the Paraventricular Nucleus of the Hypothalamus

Biddinger, Jessica E.; Lazarenko, Roman M.; Scott, Michael M.; Simerly, Richard B.

doi:10.1101/2020.06.30.180513

Cited by 1 publication

(1 citation statement)

References 61 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, long-term sucrose consumption reduced impulse control in the novelty-suppressed feeding, and this was not observed when sucrose access was restricted. Although novelty-suppressed feeding test is primarily to assess anxiety-like behaviors, studies have shown that a reduced latency to feed could be correlated with augmented food seeking and increased meal size ( Biddinger et al, 2020 ), increased hunger and reduced-feeding control after fasting ( Burghardt et al, 2016 ), and together with hyperlocomotion, increased motor impulsivity ( Bevilacqua et al, 2010 ; Angoa-Pérez et al, 2014 ; Piggott et al, 2020 ). This suggests that the reduced latency to feed we observed after long-term sucrose intake could be the result of impulsivity.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood

et al. 2021

View full text Add to dashboard Cite

Sugar has become embedded in modern food and beverages. This has led to overconsumption of sugar in children, adolescents, and adults, with more than 60 countries consuming more than four times (>100 g/person/day) the WHO recommendations (25 g/person/day). Recent evidence suggests that obesity and impulsivity from poor dietary habits leads to further overconsumption of processed food and beverages. The long-term effects on cognitive processes and hyperactivity from sugar overconsumption, beginning at adolescence are not known. Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. Our results are similar to those reported in attention deficit and hyperactivity disorders. The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. This suggests that long-term overconsumption of sugar, as that which occurs in the Western Diet might contribute to an increased risk of developing persistent hyperactivity and neurocognitive deficits in adulthood.

show abstract